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. 2000 May 2;162(9):1281–1284.

Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke

M D Hill 1, P A Barber 1, J Takahashi 1, A M Demchuk 1, T E Feasby 1, A M Buchan 1
PMCID: PMC1232409  PMID: 10813008

Abstract

Among 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy.

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Selected References

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