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CMAJ : Canadian Medical Association Journal logoLink to CMAJ : Canadian Medical Association Journal
. 1999 Jul 13;161(1):25–32.

Systematic review of antihypertensive therapies: Does the evidence assist in choosing a first-line drug?

J M Wright 1, C H Lee 1, G K Chambers 1
PMCID: PMC1232645  PMID: 10420860

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Selected References

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  1. Berglund G., Andersson O., Widgren B. Low-dose antihypertensive treatment with a thiazide diuretic is not diabetogenic. A 10-year controlled trial with bendroflumethiazide. Acta Med Scand. 1986;220(5):419–424. doi: 10.1111/j.0954-6820.1986.tb02790.x. [DOI] [PubMed] [Google Scholar]
  2. Berglund G., Andersson O. beta-blockers or diuretics in hypertension? A six year follow-up of blood pressure and metabolic side effects. Lancet. 1981 Apr 4;1(8223):744–747. doi: 10.1016/s0140-6736(81)92624-6. [DOI] [PubMed] [Google Scholar]
  3. Borhani N. O., Mercuri M., Borhani P. A., Buckalew V. M., Canossa-Terris M., Carr A. A., Kappagoda T., Rocco M. V., Schnaper H. W., Sowers J. R. Final outcome results of the Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS). A randomized controlled trial. JAMA. 1996 Sep 11;276(10):785–791. [PubMed] [Google Scholar]
  4. Casiglia E., Spolaore P., Mazza A., Ginocchio G., Colangeli G., Onesto C., Di Menza G., Pegoraro L., Ambrosio G. B. Effect of two different therapeutic approaches on total and cardiovascular mortality in a Cardiovascular Study in the Elderly (CASTEL). Jpn Heart J. 1994 Sep;35(5):589–600. doi: 10.1536/ihj.35.589. [DOI] [PubMed] [Google Scholar]
  5. Casiglia E., Spolaore P., Mormino P., Maschio O., Colangeli G., Celegon L., Maggiolo G., Tittoto L., Pasinato A., Ambrosio G. B. The CASTEL project (CArdiovascular STudy in the ELderly): protocol, study design, and preliminary results of the initial survey. Cardiologia. 1991 Jul;36(7):569–576. [PubMed] [Google Scholar]
  6. Coope J., Warrender T. S. Randomised trial of treatment of hypertension in elderly patients in primary care. Br Med J (Clin Res Ed) 1986 Nov 1;293(6555):1145–1151. doi: 10.1136/bmj.293.6555.1145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DerSimonian R., Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986 Sep;7(3):177–188. doi: 10.1016/0197-2456(86)90046-2. [DOI] [PubMed] [Google Scholar]
  8. Effect of antihypertensive treatment on stroke recurrence. Hypertension-Stroke Cooperative Study Group. JAMA. 1974 Jul 22;229(4):409–418. doi: 10.1001/jama.1974.03230420021019. [DOI] [PubMed] [Google Scholar]
  9. Gueyffier F., Froment A., Gouton M. New meta-analysis of treatment trials of hypertension: improving the estimate of therapeutic benefit. J Hum Hypertens. 1996 Jan;10(1):1–8. [PubMed] [Google Scholar]
  10. Helgeland A. Treatment of mild hypertension: a five year controlled drug trial. The Oslo study. Am J Med. 1980 Nov;69(5):725–732. doi: 10.1016/0002-9343(80)90438-6. [DOI] [PubMed] [Google Scholar]
  11. Holme I. MAPHY and the two arms of HAPPHY. JAMA. 1989 Dec 15;262(23):3272–3274. [PubMed] [Google Scholar]
  12. Insua J. T., Sacks H. S., Lau T. S., Lau J., Reitman D., Pagano D., Chalmers T. C. Drug treatment of hypertension in the elderly: a meta-analysis. Ann Intern Med. 1994 Sep 1;121(5):355–362. doi: 10.7326/0003-4819-121-5-199409010-00008. [DOI] [PubMed] [Google Scholar]
  13. Kuramoto K., Matsushita S., Kuwajima I., Murakami M. Prospective study on the treatment of mild hypertension in the aged. Jpn Heart J. 1981 Jan;22(1):75–85. doi: 10.1536/ihj.22.75. [DOI] [PubMed] [Google Scholar]
  14. Morgan T. O., Adams W. R., Hodgson M., Gibberd R. W. Failure of therapy to improve prognosis in elderly males with hypertension. Med J Aust. 1980 Jul 12;2(1):27–31. [PubMed] [Google Scholar]
  15. Mulrow C. D., Cornell J. A., Herrera C. R., Kadri A., Farnett L., Aguilar C. Hypertension in the elderly. Implications and generalizability of randomized trials. JAMA. 1994 Dec 28;272(24):1932–1938. [PubMed] [Google Scholar]
  16. Perry H. M., Jr, Smith W. M., McDonald R. H., Black D., Cutler J. A., Furberg C. D., Greenlick M. R., Kuller L. H., Schnaper H. W., Schoenberger J. A. Morbidity and mortality in the Systolic Hypertension in the Elderly Program (SHEP) pilot study. Stroke. 1989 Jan;20(1):4–13. doi: 10.1161/01.str.20.1.4. [DOI] [PubMed] [Google Scholar]
  17. Philipp T., Anlauf M., Distler A., Holzgreve H., Michaelis J., Wellek S. Randomised, double blind, multicentre comparison of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in antihypertensive treatment: results of the HANE study. HANE Trial Research Group. BMJ. 1997 Jul 19;315(7101):154–159. doi: 10.1136/bmj.315.7101.154. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Psaty B. M., Smith N. L., Siscovick D. S., Koepsell T. D., Weiss N. S., Heckbert S. R., Lemaitre R. N., Wagner E. H., Furberg C. D. Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis. JAMA. 1997 Mar 5;277(9):739–745. [PubMed] [Google Scholar]
  19. Rosei E. A., Dal Palù C., Leonetti G., Magnani B., Pessina A., Zanchetti A. Clinical results of the Verapamil inHypertension and Atherosclerosis Study. VHAS Investigators. J Hypertens. 1997 Nov;15(11):1337–1344. doi: 10.1097/00004872-199715110-00019. [DOI] [PubMed] [Google Scholar]
  20. Sprackling M. E., Mitchell J. R., Short A. H., Watt G. Blood pressure reduction in elderly: a randomised controlled trial of methyldopa. Br Med J (Clin Res Ed) 1981 Oct 31;283(6300):1151–1153. doi: 10.1136/bmj.283.6300.1151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Staessen J. A., Fagard R., Thijs L., Celis H., Arabidze G. G., Birkenhäger W. H., Bulpitt C. J., de Leeuw P. W., Dollery C. T., Fletcher A. E. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet. 1997 Sep 13;350(9080):757–764. doi: 10.1016/s0140-6736(97)05381-6. [DOI] [PubMed] [Google Scholar]
  22. Strandberg T. E., Salomaa V. V., Naukkarinen V. A., Vanhanen H. T., Sarna S. J., Miettinen T. A. Long-term mortality after 5-year multifactorial primary prevention of cardiovascular diseases in middle-aged men. JAMA. 1991 Sep 4;266(9):1225–1229. [PubMed] [Google Scholar]
  23. Thijs L., Fagard R., Lijnen P., Staessen J., Van Hoof R., Amery A. A meta-analysis of outcome trials in elderly hypertensives. J Hypertens. 1992 Oct;10(10):1103–1109. doi: 10.1097/00004872-199210000-00001. [DOI] [PubMed] [Google Scholar]
  24. Wikstrand J., Warnold I., Olsson G., Tuomilehto J., Elmfeldt D., Berglund G. Primary prevention with metoprolol in patients with hypertension. Mortality results from the MAPHY study. JAMA. 1988 Apr 1;259(13):1976–1982. [PubMed] [Google Scholar]

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