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. 1979 Sep;129(Pt 2):279–292.

Effect of catecholamines on lymphopoiesis in fetal mouse thymic explants.

U Singh
PMCID: PMC1233047  PMID: 315401

Abstract

Fetal thymic explants (14 days of gestation) from Balb/c mice were grown in organ culture for up to 12 days and the pattern of lymphopoiesis was monitored by 125IUdR incorporation and cell yields of such lobes in the presence of adrenergic agents. It was observed that, after 3 days of cultures, phenylephrine stimulated lymphopoiesis in thymic explants, whereas some inhibition was observed with isoproterenol. These observations were confirmed by autoradiography. It was also observed that cells obtained from phenylephrine-treated cultures had greater mitogen reactivity than either control (untreated) or isoproterenol-treated cultures. The possible role of cyclic nucleotides as intracellular mediators of thymocyte maturation is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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