Abstract
The changes in the distribution of lipid droplets in the liver lobule were studied during the postnatal development of the mouse. At birth, and 1 day after birth, lipid droplets were evenly distributed throughout the lobule. A slightly uneven distribution of the droplets, more in centrilobular areas, appeared 2 days after birth. After this the difference in the number of droplets between the cells of the centrilobular and periportal areas became progressively more marked reaching a maximum by 17 days of age, and then decreasing to the adult level between 21 and 24 days. Thus, heterogeneity among hepatocytes with respect to lipid content is not present in newborn mice but develops gradually during the postnatal development.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cutts J. H., Leeson C. R., Krause W. J. The postnatal development of the liver in a marsupial, Didelphis virginiana. 1. Light microscopy. J Anat. 1973 Sep;115(Pt 3):327–346. [PMC free article] [PubMed] [Google Scholar]
- Kanamura S. Postanal changes in the localization of glucose 6-phosphatase activity within the liver lobule of the mouse. Anat Rec. 1975 Mar;181(3):635–640. doi: 10.1002/ar.1091810306. [DOI] [PubMed] [Google Scholar]
- LeBouton A. V. Growth, mitosis and morphogenesis of the simple liver acinus in neonatal rats. Dev Biol. 1974 Nov;41(1):22–30. doi: 10.1016/0012-1606(74)90279-6. [DOI] [PubMed] [Google Scholar]
- LeBouton A. V., Marchand R. Changes in the distribution of thymidine-3H labeled cells in the growing liver acinus of neonatal rats. Dev Biol. 1970 Dec;23(4):524–533. doi: 10.1016/0012-1606(70)90138-7. [DOI] [PubMed] [Google Scholar]
- Leeson C. R., Cutts J. H. The postnatal development of the rabbit liver. Biol Neonate. 1972;20(5):404–413. doi: 10.1159/000240482. [DOI] [PubMed] [Google Scholar]