Abstract
Metabolism requires precise gene regulation to balance energy intake and expenditure for an organism’s well-being, with misregulation often leading to metabolic syndromes. This study reveals that the brain-specific microRNA miR-1000 regulates fat storage by controlling the expression of a neuropeptide gene, Nplp1 . Loss of miR-1000 increases Nplp1 expression, leading to higher body weight, increased fat storage, improved survival under food deprivation conditions, and a reduced overall lifespan in Drosophila . We further show that miR-1000 promotes fat storage upon feeding by regulating TAG synthesis and storage in lipid droplets, thereby playing a crucial role in metabolic regulation.
Full Text Availability
The license terms selected by the author(s) for this preprint version do not permit archiving in PMC. The full text is available from the preprint server.
