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. 1980 Aug;131(Pt 1):25–37.

Ultrastructure of developing human ductus arteriosus.

T Toda, N Tsuda, T Takagi, I Nishimori, D Leszczynski, F Kummerow
PMCID: PMC1233285  PMID: 7440403

Abstract

Histological and ultrastructural studies were made of 25 specimens of human ductus arteriosus obtained from abortion of autopsy, and ranging in age from 15 weeks of gestation to 7 years. Samples of ductus with normal muscular type structure exhibited active intimal thickening as early as 15 weeks' gestational age when the internal elastic lamina was found to be focally discontinuous. At the same time, intimal smooth muscle cells were closely arranged, and often intimately connected to cells of the tunica media. Ultrastructurally, both smooth muscle cells and endothelial cells at 15 weeks' gestational age contained abundant glycogen deposits. From 18-32 weeks' gestational age, glycogen deposits gradually disappeared, collagen fibres began to appear in the extracellular space and the first signs of smooth collagen fibres began to appear in the extracellular space and the first signs of smooth muscle cell degeneration became apparent. After birth, intimal thickening and degeneration of smooth muscle cells was much more pronounced. The ultrastructure of intimal smooth muscle cells indicated that intimal thickening was caused by smooth muscle cell migration as opposed to rapid proliferation; and both intracellular and extracellular membrane-bound lipid-filled vacuoles were commonly seen in the more advanced stages of degeneration. Of the ductus specimens examined, three were rich in elastic fibres. Two of these three specimens were from a group of 10 abortion cases, and the third was from a 2 weeks old full term infant who had been exposed to maternal rubella. The 2 weeks old infant had a widely patent ductus arteriosus; whether the two fetal specimens with ductus elastosis would have eventually developed into clinical patent ductus arteriosus was not clear.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CAMPBELL M. Place of maternal rubella in the aetiology of congenital heart disease. Br Med J. 1961 Mar 11;1(5227):691–696. doi: 10.1136/bmj.1.5227.691. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Gittenberger-de Groot A. C. Persistent ductus arteriosus: most probably a primary congenital malformation. Br Heart J. 1977 Jun;39(6):610–618. doi: 10.1136/hrt.39.6.610. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Heymann M. A., Rudolph A. M., Silverman N. H. Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. N Engl J Med. 1976 Sep 2;295(10):530–533. doi: 10.1056/NEJM197609022951004. [DOI] [PubMed] [Google Scholar]
  4. Hörnblad P. Y. Embryological observations of the ductus arteriosus in the guinea-pig, rabbit, rat and mouse. Studies on closure of the ductus arteriosus. IV. Acta Physiol Scand. 1969 May-Jun;76(1):49–57. doi: 10.1111/j.1748-1716.1969.tb04450.x. [DOI] [PubMed] [Google Scholar]
  5. Imamura H., Okamoto N., Satow Y., Hidaka N., Akimoto N. Closure of the ductus arteriosus in normal and malformed human heart. Hiroshima J Med Sci. 1978 Mar;27(1):47–59. [PubMed] [Google Scholar]
  6. Jager B. V., Wollenman O. J. An Anatomical Study of the Closure of the Ductus Arteriosus. Am J Pathol. 1942 Jul;18(4):595–613. [PMC free article] [PubMed] [Google Scholar]
  7. KOVALCIK V. THE RESPONSE OF THE ISOLATED DUCTUS ARTERIOSUS TO OXYGEN AND ANOXIA. J Physiol. 1963 Nov;169:185–197. doi: 10.1113/jphysiol.1963.sp007249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Mato M., Aikawa E. Some observations on the obliteration of ductus arteriosus Botalli using the electron microscope. Z Anat Entwicklungsgesch. 1968;127(4):327–345. doi: 10.1007/BF00524420. [DOI] [PubMed] [Google Scholar]
  9. Mato M., Aikawa E., Uchiyama Y. Radioautographic study on the obliteration of the ductus arteriosus botalli. Virchows Arch A Pathol Pathol Anat. 1970;349(1):10–20. doi: 10.1007/BF00548519. [DOI] [PubMed] [Google Scholar]
  10. McMurphy D. M., Heymann M. A., Rudolph A. M., Melmon K. L. Developmental changes in constriction of the ductus arteriosus: responses to oxygen and vasoactive agents in the isolated ductus arteriosus of the fetal lamb. Pediatr Res. 1972 Apr;6(4):231–238. doi: 10.1203/00006450-197204000-00004. [DOI] [PubMed] [Google Scholar]
  11. Schwartz S. M., Stemerman M. B., Benditt E. P. The aortic intima. II. Repair of the aortic lining after mechanical denudation. Am J Pathol. 1975 Oct;81(1):15–42. [PMC free article] [PubMed] [Google Scholar]
  12. Strong W. B. Is atherosclerosis a pediatric problem? Med Times. 1976 Jan;104(1):65–75. [PubMed] [Google Scholar]
  13. Taura S., Taura M., Kummerow F. A., Kamio A., Takebayashi S. Mitotic structure of aortic intimal cells induced by mechanical injury in swine. Acta Pathol Jpn. 1978 Jul;28(4):555–564. doi: 10.1111/j.1440-1827.1978.tb00895.x. [DOI] [PubMed] [Google Scholar]
  14. Wissler R. W. Atherosclerosis--its pathogenesis in perspective. Adv Cardiol. 1974;13:10–31. doi: 10.1159/000395523. [DOI] [PubMed] [Google Scholar]
  15. Zollinger H. U. Adaptive Intimafibrose der Arterien. Virchows Arch Pathol Anat Physiol Klin Med. 1967 Mar 14;342(2):154–164. [PubMed] [Google Scholar]

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