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. 1994 Oct;220(4):578–585. doi: 10.1097/00000658-199410000-00016

Nonheartbeating cadaveric organ donation.

M S Orloff 1, A I Reed 1, E Erturk 1, R A Kruk 1, S A Paprocki 1, S C Cimbalo 1, G J Cerilli 1
PMCID: PMC1234438  PMID: 7944668

Abstract

OBJECTIVE: The authors evaluated the potential use of nonheartbeating (NHB) cadaver donors as an additional source to the current supply of brain-dead cadaver donors. SUMMARY BACKGROUND DATA: The numbers of cadaveric donors has not increased significantly during the last 5 years, despite a rising need for transplantable organs. Any improvement in cadaveric organ procurement will depend on the use of previously unrecognized potential donors. METHODS: During a 2-year period, 24 kidneys were retrieved from 12 NHB donors. Nineteen kidneys were transplanted. RESULTS: These kidneys sustained a mean warm ischemia time of 26 minutes (range 20-35 min). A mean lowest creatinine level of 2.0 mg/dL, (range 1.1-3.0 mg/dL), the rate of postoperative dialysis (22%), and a 1-year graft survival rate of 76% for kidneys from NHB-donated kidneys compare favorably to expected results achieved nationally from brain-dead cadaveric donors. CONCLUSIONS: Nonheartbeating donor kidneys can yield acceptable graft function and be of no disadvantage to recipients of cadaver transplants.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anaise D., Smith R., Ishimaru M., Waltzer W. C., Shabtai M., Hurley S., Rapaport F. T. An approach to organ salvage from non-heartbeating cadaver donors under existing legal and ethical requirements for transplantation. Transplantation. 1990 Feb;49(2):290–294. doi: 10.1097/00007890-199002000-00013. [DOI] [PubMed] [Google Scholar]
  2. Belzer F. O., Hoffman R. M., Southard J. H. Kidney preservation. Surg Clin North Am. 1978 Apr;58(2):261–271. doi: 10.1016/s0039-6109(16)41482-9. [DOI] [PubMed] [Google Scholar]
  3. Belzer F. O., Hoffman R. M., Stratta R. J., D'Alessandro A., Pirsch J., Kalayoglu M., Sollinger H. W. Combined cold storage-perfusion preservation of the kidney with a new synthetic perfusate. Transplant Proc. 1989 Feb;21(1 Pt 2):1240–1241. [PubMed] [Google Scholar]
  4. Castelao A. M., Griñ J. M., González C., Franco E., GilVernet S., Andrés E., Serón D., Torras J., Moreso F., Alsina J. Update of our experience in long-term renal function of kidneys transplanted from non-heart-beating cadaver donors. Transplant Proc. 1993 Feb;25(1 Pt 2):1513–1515. [PubMed] [Google Scholar]
  5. Kootstra G., Wijnen R., van Hooff J. P., van der Linden C. J. Twenty percent more kidneys through a non-heart beating program. Transplant Proc. 1991 Feb;23(1 Pt 2):910–911. [PubMed] [Google Scholar]
  6. Matsuno N., Kozaki M., Sakurai E., Uchiyama M., Iwahori T., Kozaki K., Kono K., Tanaka M., Tamaki T., Tamaki I. Effect of combination in situ cooling and machine perfusion preservation on non-heart-beating donor kidney procurement. Transplant Proc. 1993 Feb;25(1 Pt 2):1516–1517. [PubMed] [Google Scholar]
  7. Wynen R. M., Booster M., Speatgens C., Yin M., van Hooff J. P., de Boer J., Kootstra G. Long-term follow-up of transplanted non-heart-beating donor kidneys: preliminary results of a retrospective study. Transplant Proc. 1993 Feb;25(1 Pt 2):1522–1523. [PubMed] [Google Scholar]

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