Abstract
The relationship between lung liquid flow and fetal lung development has been studied at the cellular level using ultrastructural techniques. Continuous in utero tracheal ligation and drainage (over a period of 21-28 days) both result in malformations of the developing fetal lamb lung. Ligated lungs are larger, and drained lungs are smaller, than normal lungs at a similar gestational age. These changes are not merely due to altered lung liquid volume, but actual tissue growth thas been affected. Future alveolar wall thinning is enhanced in ligated lungs and inhibited in drained lungs, whilst the presence of differentiated alveolar type II cells (probably related to surfactant production) is decreased in ligated lungs and markedly enhanced in drained lungs. These results indicate the importance of fetal lung liquid in the regulation of pulmonary development in the fetus.
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- Adamson T. M., Brodecky V., Lambert T. F., Maloney J. E., Ritchie B. C., Walker A. M. Lung liquid production and composition in the "in utero" foetal lamb. Aust J Exp Biol Med Sci. 1975 Feb;53(1):65–75. doi: 10.1038/icb.1975.7. [DOI] [PubMed] [Google Scholar]
- Blackburn W. R., Travers H., Potter D. M. The role of the pituitary-adrenal-thyroid axes in lung differentiation. I. Studies of the cytology and physical properties of anencephalic fetal rat lung. Lab Invest. 1972 Mar;26(3):306–318. [PubMed] [Google Scholar]
- CARMEL J. A., FRIEDMAN F., ADAMS F. H. FETAL TRACHEAL LIGATION AND LUNG DEVELOPMENT. Am J Dis Child. 1965 May;109:452–456. doi: 10.1001/archpedi.1965.02090020454014. [DOI] [PubMed] [Google Scholar]
- Chiswick M. L., Ahmed A., Jack P. M., Milner R. D. Control of fetal lung development in the rabbit. Arch Dis Child. 1973 Sep;48(9):709–713. doi: 10.1136/adc.48.9.709. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Griscom N. T., Harris G. B., Wohl M. E., Vawter G. F., Eraklis A. J. Fluid-filled lung due to airway obstruction in the newborn. Pediatrics. 1969 Mar;43(3):383–390. [PubMed] [Google Scholar]
- Humphreys P. W., Normand I. C., Reynolds E. O., Strang L. B. Pulmonary lymph flow and the uptake of liquid from the lungs of the lamb at the start of breathing. J Physiol. 1967 Nov;193(1):1–29. doi: 10.1113/jphysiol.1967.sp008340. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kikkawa Y., Kaibara M., Motoyama E. K., Orzalesi M. M., Cook C. D. Morphologic development of fetal rabbit lung and its acceleration with cortisol. Am J Pathol. 1971 Aug;64(2):423–442. [PMC free article] [PubMed] [Google Scholar]
- Knelson J. H. Environmental influence on intrauterine lung development. Arch Intern Med. 1971 Mar;127(3):421–425. [PubMed] [Google Scholar]
- Kotas R. V., Avery M. E. Accelerated appearance of pulmonary surfactant in the fetal rabbit. J Appl Physiol. 1971 Mar;30(3):358–361. doi: 10.1152/jappl.1971.30.3.358. [DOI] [PubMed] [Google Scholar]
- Maloney J. E., Adamson T. M., Brodecky A. V., Cranage S., Lambert T. F., Ritchie B. C. Diaphragmatic activity and lung liquid flow in the unanesthetized fetal sheep. J Appl Physiol. 1975 Sep;39(3):423–428. doi: 10.1152/jappl.1975.39.3.423. [DOI] [PubMed] [Google Scholar]
- McDougall J., Smith J. F. The development of the human type II pneumocyte. J Pathol. 1975 Apr;115(4):245–251. doi: 10.1002/path.1711150410. [DOI] [PubMed] [Google Scholar]
- Meyrick B., Bearn J. G., Cobb A. G., Monkhouse C. R., Reid L. The effect of in utero decapitation on the morphological and physiological development of the fetal rabbit lung. J Anat. 1975 Jul;119(Pt 3):517–535. [PMC free article] [PubMed] [Google Scholar]
- Normand I. C., Olver R. E., Reynolds E. O., Strang L. B. Permeability of lung capillaries and alveoli to non-electrolytes in the foetal lamb. J Physiol. 1971 Dec;219(2):303–330. doi: 10.1113/jphysiol.1971.sp009663. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Scarpelli E. M., Condorelli S., Cosmi E. V. Lamb fetal pulmonary fluid. I. Validation and significance of method for determination of volume and volume change. Pediatr Res. 1975 Apr;9(4):190–195. doi: 10.1203/00006450-197504000-00010. [DOI] [PubMed] [Google Scholar]
- Smith B. T., Torday J. S., Giroud C. J. Evidence for different gestation-dependent effects of cortisol on cultured fetal lung cells. J Clin Invest. 1974 Jun;53(6):1518–1526. doi: 10.1172/JCI107702. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thurlbeck W. M. Postnatal growth and development of the lung. Am Rev Respir Dis. 1975 Jun;111(6):803–844. doi: 10.1164/arrd.1975.111.6.803. [DOI] [PubMed] [Google Scholar]