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Journal of Anatomy logoLink to Journal of Anatomy
. 1977 Nov;124(Pt 2):401–411.

The proliferation of elastic fibres after skin incisions in albino mice and rats: a light and electron microscopic study.

D Schwartz
PMCID: PMC1234844  PMID: 591436

Abstract

The replacement of elastic fibres in healing skin wounds in mice and rats was studied with light and electron microscopy. New elastic fibres were seen 1 week post-wounding in the deepest regions of the scar. By 3 weeks post-wounding they could be found in the regenerating dermis. There followed a proliferation of these fibres to numbers far greater than those in unwounded skin. These elevated numbers persisted for the duration of the experiment (4 months). The common notion that elastic fibre formation is not a component of the repair of skin wounds is clearly erroneous.

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Selected References

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  1. Brissie R. M., Spicer S. S., Thompson N. T. The variable fine structure of elastin visualized with Verhoeff's iron hematoxylin. Anat Rec. 1975 Jan;181(1):83–94. doi: 10.1002/ar.1091810107. [DOI] [PubMed] [Google Scholar]
  2. Converse J. M., Robb-Smith A. H. The Healing of Surface Cutaneous Wounds: Its Analogy With the Healing of Superficial Burns. Ann Surg. 1944 Dec;120(6):873–885. doi: 10.1097/00000658-194412000-00006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DUNPHY J. E., JACKSON D. S. Practical applications of experimental studies in the care of te primarily closed wound. Am J Surg. 1962 Aug;104:273–282. doi: 10.1016/0002-9610(62)90328-8. [DOI] [PubMed] [Google Scholar]
  4. Greenlee T. K., Jr, Ross R., Hartman J. L. The fine structure of elastic fibers. J Cell Biol. 1966 Jul;30(1):59–71. doi: 10.1083/jcb.30.1.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HADFIELD G. THE EARLIER PHASES OF DEFINITIVE HEALING IN AN EXPERIMENTAL SKIN WOUND. Br J Surg. 1963 Jul;50:751–764. doi: 10.1002/bjs.18005022514. [DOI] [PubMed] [Google Scholar]
  6. Hinshaw J. R., Miller E. R. Histology of healing split-thickness, full-thickness autogenous skin grafts and donor sites. Arch Surg. 1965 Oct;91(4):658–670. doi: 10.1001/archsurg.1965.01320160112027. [DOI] [PubMed] [Google Scholar]
  7. KARRER H. E. Electron microscope study of developing chick embryo aorta. J Ultrastruct Res. 1960 Dec;4:420–454. doi: 10.1016/s0022-5320(60)80032-9. [DOI] [PubMed] [Google Scholar]
  8. LEVENSON S. M., GEEVER E. F., CROWLEY L. V., OATES J. F., 3rd, BERARD C. W., ROSEN H. THE HEALING OF RAT SKIN WOUNDS. Ann Surg. 1965 Feb;161:293–308. doi: 10.1097/00000658-196502000-00019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. LUFT J. H. Improvements in epoxy resin embedding methods. J Biophys Biochem Cytol. 1961 Feb;9:409–414. doi: 10.1083/jcb.9.2.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Madden J. W., Peacock E. E., Jr Studies on the biology of collagen during wound healing. 3. Dynamic metabolism of scar collagen and remodeling of dermal wounds. Ann Surg. 1971 Sep;174(3):511–520. doi: 10.1097/00000658-197109000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Madden J. W., Peacock E. E., Jr Studies on the biology of collagen during wound healing. I. Rate of collagen synthesis and deposition in cutaneous wounds of the rat. Surgery. 1968 Jul;64(1):288–294. [PubMed] [Google Scholar]
  12. Ordman L. J., Gillman T. Studies in the healing of cutaneous wounds. I. The healing of incisions through the skin of pigs. Arch Surg. 1966 Dec;93(6):857–882. doi: 10.1001/archsurg.1966.01330060001001. [DOI] [PubMed] [Google Scholar]
  13. RHODIN J., DALHAMN T. Electron microscopy of collagen and elastin in lamina propria of the tracheal muscosa of rat. Exp Cell Res. 1955 Oct;9(2):371–375. doi: 10.1016/0014-4827(55)90116-6. [DOI] [PubMed] [Google Scholar]
  14. Ross R. The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. J Cell Biol. 1971 Jul;50(1):172–186. doi: 10.1083/jcb.50.1.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Van Winkle W., Jr The tensile strength of wounds and factors that influence it. Surg Gynecol Obstet. 1969 Oct;129(4):819–842. [PubMed] [Google Scholar]
  16. WOOD G. C. Some tensile properties of elastic tissue. Biochim Biophys Acta. 1954 Nov;15(3):311–324. doi: 10.1016/0006-3002(54)90032-3. [DOI] [PubMed] [Google Scholar]
  17. Williams G. The late phases of wound healing: histological and ultrastructural studies of collagen and elastic-tissue formation. J Pathol. 1970 Oct;102(2):61–68. doi: 10.1002/path.1711020202. [DOI] [PubMed] [Google Scholar]

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