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. 2025 Aug 22;13:1384. Originally published 2024 Nov 18. [Version 2] doi: 10.12688/f1000research.158490.2

Cognitive function and its determinants in elderly Indonesians residing in long-term care: Insights from a cross-sectional study

Etty Rekawati 1,a, Winda Eriska 1, Utami Rachmawati 1, Dwi Nurviyandari Kusuma Wati 1, Junaiti Sahar 1, Arief Andriyanto 2, Jing-Jy Wang 3,4, Sri Susanty 5, Faizul Hasan 6,b
PMCID: PMC12355162  PMID: 40822436

Version Changes

Revised. Amendments from Version 1

The revisions enhance transparency by clarifying sampling, exclusions, and model-building. Novelty is highlighted by emphasizing the study's focus on institutionalized elderly—an understudied population—and its global relevance. Reproducibility is strengthened with details on data distribution and missingness. These changes address all reviewer feedback while maintaining the manuscript's core strengths.

Abstract

Background

Multiple medical conditions arising from reduced physical and physiological functioning, including cognitive decline, manifest in older persons. This study aims to examine the relationship between cognitive function and associated risk factors in older persons living in long-term care facilities in Indonesia.

Methods

This study involved 350 elderly individuals residing in long-term care institutions. A cross-sectional design utilizing an analytical survey methodology was implemented. Data were gathered via interviews employing a demographic questionnaire and the Montreal Cognitive Assessment (MoCA). Statistical analysis was conducted using SPSS (version 23).

Results

Univariate analysis demonstrated significant correlations between cognitive performance and gender, ethnicity, level of education, medical history, subjective memory issues, smoking habits, alcohol consumption, dietary intake of fruits and vegetables, and employment history (p < 0.05). Higher education (OR = 0.69, 95% CI: 0.56–0.84) and reduced subjective memory complaints (OR = 0.29, 95% CI: 0.20–0.44) correlated positively with enhanced cognitive function, but alcohol intake (OR = 6.79, 95% CI: 2.42–19.1) correlated with impaired cognitive function.

Conclusions

the level of education, subjective memory complaints, and alcohol intake are substantially correlated with cognitive performance in older persons residing in long-term care facilities. Evaluating demographic characteristics in elderly individuals can assist healthcare professionals in the early detection of cognitive impairment, facilitating prompt interventions in long-term care environments.

Keywords: Cognitive function; elderly individuals; risk factors

Introduction

By 2030, one in six individuals worldwide will be senior citizens. In Indonesia, life expectancy improved from 68.6 years in 2018 to 71.8 years in 2022, with an anticipated increase of 72.2 years for the period 2030–2035. 1 The 2022 Indonesia National Health Survey indicated that 10.5% of the population comprises elderly persons. 2 The aging population has transitioned the illness burden from infectious diseases and malnutrition to chronic ailments such as diabetes, hypertension, neoplasms, and coronary heart disease. 3 These alterations hinder daily functioning and augment economic dependency. 4 Moreover, physical, mental, and emotional deterioration intensifies reliance, impairing social interactions, self-care, and health management. 5

Mental changes in older persons encompass transformations in personality, memory, and cognitive ability, shaped by socio-demographic, physical, and psychological factors, 69 with loneliness, social isolation, 7, 10, 11 and late-life mental diseases. 6 With the expansion of the older adult demographic, cognitive impairment has become increasingly common. 8 Cognitive function denotes the capacity to uphold responsibilities and social interactions, and its deterioration impedes engagement with family and community, imposing a burden on caregivers and communities. 12

Numerous individual factors affect cognitive decline, including age, 13 gender, 1416 level of education, 1719 genetics, and medical history. Chronic disorders include hypertension, 20, 21 diabetes, 2224 cardiovascular diseases, 25, 26 gastritis, 2729 and depression 30, 31 exacerbate cognitive impairment. Environmental factors, including social engagement and physical activity, significantly influence outcomes. 3234

Research has revealed multiple indicators strongly linked to motor-cognitive risk, including extremity functional limits, activities of daily living (ADL) impairment, fatigue, and hypertension. 35 Age, medical history, depression, and resilience are determinants of cognitive function. 36 Timely recognition and intervention of these factors are crucial to avert or alleviate cognitive impairment in elderly individuals. 37 Neuropsychological evaluations, like the Mini Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA), are essential instruments for identifying cognitive deficits, with MoCA demonstrating heightened sensitivity. 5

Long-term care in Indonesia offers help for anyone requiring extended assistance, especially the elderly or individuals with disabilities. Nonetheless, there is a lack of particular data regarding the population of older adults residing in Long-Term Care Institutions (LTCI). The swift expansion of the elderly demographic has heightened the demand for long-term care insurance, influenced by evolving social dynamics and diminished familial capacity to offer care. Nevertheless, no previous research has investigated the correlation between cognitive function, medical history, and related risk factors in elderly individuals, impeding healthcare practitioners’ capacity to execute preventive measures and inform families.

Unlike previous regional studies that predominantly examined community-dwelling elderly, this study focuses on older persons residing in LTCIs, a population with distinct vulnerabilities that has rarely been explored in Indonesia. By addressing this gap, the study provides novel insights that not only contextualize cognitive health in institutional care within Indonesia but also contribute to the broader global discourse on aging, long-term care, and cognitive decline. This cross-sectional study aims to examine the relationship between cognitive function and associated risk factors among older persons in long-term care institutions in Indonesia.

Methods

Study setting and participants

This analytical cross-sectional study was performed in the major Long-Term Care Institutions in Jakarta, Indonesia, from February to April 2023. It comprised older people (≥60 years) devoid of eyesight or hearing impairments. Participants with visual or hearing impairments were excluded because the MoCA-Ina requires intact sensory abilities to ensure valid measurement of cognitive function. Deficits in vision or hearing could interfere with item completion and lead to misinterpretation of test scores as cognitive impairment. Participants were selected using purposive sampling. All residents in the two LTCIs who met the eligibility criteria were screened and included in the study. This approach allowed the inclusion of the entire eligible population. During the preliminary phase, health records were examined to ascertain eligible participants, contingent upon the nursing home’s consent. A total of 350 elderly people participated in the study. Specifically, two major long-term care institutions in Jakarta participated in this study. In addition, the study follow the STROBE guideline ( https://www.equator-network.org/).

Variables and measures

Demographic characteristics

Data were obtained via in-person interviews. Demographic variables encompassed age, duration of residence in long-term care institutions and nursing homes, gender, religion, ethnicity, relationship status, level of education, medical history, subjective memory issues, tobacco use, alcohol intake, daily consumption of fruits and vegetables, employment background, utilization of mobility aids, and living situation.

The montreal cognitive assessment (MoCA-Ina)

The Indonesian adaptation of the Montreal Cognitive Assessment (MoCA-Ina) was utilized, with all procedures executed in the native language, Bahasa Indonesia, to guarantee participant comfort. MoCA-Ina has exhibited robust reliability and validity, evidenced by a Cronbach’s alpha of 0.976, signifying exceptional internal consistency. 38 Cognitive function, the principal variable, was evaluated using the 30-point MoCA-Ina, with scores ≥11 signifying strong cognitive function and scores <11 denoting low cognitive function. MoCA-Ina is a reliable and sensitive instrument for identifying moderate cognitive impairment in elderly individuals in Indonesia. 39

Data collection procedure

Ten trained enumerators aided senior citizens in completing the questionnaire. Authorization was secured from the facility director, and the study protocols were comprehensively elucidated. Subsequent to approval, enumerators obtained consent from participants, who signed consent forms upon their agreement to participate. Eligible participants were apprised of the study’s objectives, advantages, and methodologies prior to receiving the questionnaire. Participation was optional and confidential, with each session lasting 15 to 20 minutes.

Ethical consideration

Prior to the investigation, this study has approval from the institutional review board (IRB) Committee of Universitas Indonesia with approval number of KET-168/UN2.F12.D1.2.1/PPM.00.02/2022 on June 21, 2022. This study adhered to the Declaration of Helsinki ( https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/). Written informed consent was obtained from participants prior joining the study and were apprised of the study’s objectives, benefits, and methods.

Data analysis

All the information collected were input into Microsoft Excel and analyzed utilizing SPSS version 23 (IBM SPSS Statistics Version 29, 2023). Descriptive data were displayed as numerical values and percentages. Chi-square tests were performed to evaluate the relationships between independent factors and cognitive function. Univariate analysis utilizing logistic regression calculated unadjusted odds ratios and their respective 95% confidence intervals (CIs) for all relevant risk factors, with significance established at p < 0.05. Variables were included in the multivariate logistic regression model if they were theoretically relevant based on prior research on cognitive decline and/or demonstrated statistical significance in univariate analysis at a threshold of p < 0.25. This approach ensured that the model captured both conceptually important and empirically supported factors.

Results

Demographic characteristics

The frequency distribution of all demographic and clinical variables is presented in Table 1. No missing data were identified in the dataset, as all 350 participants provided complete information across the included variables.

Table 1. Demographic characteristics of older adults in nursing homes (n = 350).

Frequency (%)
Length of stay in nursing home (years)
 ≤ 3 227 64.9
 > 3 123 35.1
Gender
 Male 157 44.9
 Female 193 55.1
Religion
 Islam 303 86.6
 Christianity/Protestantism 35 10
 Catholicism 4 1.1
 Buddhism 5 1.4
 Hinduism 2 0.6
 Other 1 0.3
Ethnic group
 Javanese 135 38.6
 Sundanese 51 14.6
 Betawi 97 27.7
 Sumatran 44 12.6
 Chinese 9 2.6
 Other 14 4.0
Marital status
 Married 138 39.4
 Divorced dead 79 22.6
 Divorced alive 38 10.9
 Single 95 27.1
Education level
 No schooling 52 14.9
 Did not graduate from elementary school 93 26.6
 Graduated from elementary school 107 30.6
 Graduated from junior high school 44 12.6
 Graduated from high school 47 13.4
 Diploma/Other higher education school 7 2.0
Disease history
 Hypertension (HT) 50 14.3
 Diabetes mellitus (DM) 6 1.7
 Cholesterol 2 0.6
 Heart failure 2 0.6
 Depression 5 1.4
 Mental disorders 65 18.6
 Strokes 8 2.3
 Arthritis 14 4.0
 Cataracts 5 1.4
 Gastritis 3 0.9
Subjective memory complaint
 Very bad 3 0.9
 Bad 77 22.0
 Medium 183 52.3
 Very good 87 24.9
Smoking
 Yes (active) 79 22.6
 Yes (passive) 8 2.3
 Stopped 47 13.4
 Does not smoke 216 61.7
Consumption of alcoholic beverages
 Which, now 3 0.9
 Which, once was 38 10.9
 Never 309 88.3
Consumption of fruits and vegetables every day
 Yes 317 90.6
 No 33 9.4
Employment history
 Formal/professional work 10 2.9
 Informal work 335 95.7
 Retired 5 1.4
Use of walking aids
 Yes 44 12.6
 No 306 87.4
Living arrangement
 Living with family 142 40.6
 Alone 208 59.4
MoCA
 High cognitive function 199 56.9
 Low cognitive function 151 43.1

MoCA: Montreal Cognitive Assessment.

Overall, the mean age of participants was 68.9 years (SD 7.01), with a median of 68. The mean duration of residence in the long-term care institution (LTCI) was almost 3 years (SD 3.6), with a median of 3 years. The average cognitive function score was 12.8 (SD 7.25), with a median of 11.

Table 1 reveals that the predominant demographic of respondents consisted of early seniors (60-68 years old), with 186 participants (53.1%), whereas 164 participants (46.9%) were older. Over fifty percent resided in the institution for fewer than three years (227 participants, 64.9%). Female enrollment was greater, with 193 individuals (55.1%), in contrast to male enrollment, which comprised 157 persons (44.9%). The majority of participants identified as Muslim (303 participants, 86.6%), with 148 (42.3%) reporting good health, and hypertension as the most prevalent health concern (50 individuals, 14.3%). The majority consisted of married individuals (138 participants, 39.4%), those of Javanese ethnicity (135 participants, 38.6%), and elementary school graduates (107 participants, 30.6%).

Participants indicated moderate subjective memory problems (183 participants, 52.3%), with the majority abstaining from alcohol consumption (309 participants, 88.3%) and not engaging in smoking (216 participants, 61.7%). A considerable percentage of participants ingested fruits and vegetables daily (317 participants, 90.6%). Nearly all participants were informal workers (335 individuals, 95.7%). Fifty-nine point four percent of participants had previously lived alone (208 participants), whereas forty point six percent lived with family (142 participants). Additionally, fifty-nine point four percent of participants (208 individuals) did not utilize walking assistance. A total of 199 participants (56.9%) achieved higher scores on the MoCA, whilst 151 participants (43.1%) attained lower scores.

Univariate analysis

Table 2 illustrates the association between participant characteristics and MoCA scores, which function as an indicator of cognitive ability. The findings demonstrate that multiple factors significantly correlate with MoCA scores, including gender, ethnicity, level of education, medical history, subjective memory issues, smoking behaviors, alcohol intake, dietary practices (particularly fruit and vegetable consumption), and employment background.

Table 2. Association between cognitive levels and risk factors in older adults living in nursing homes.

Variable Total MoCA Score P-Value
(n= 350) High cognitive function (%) Low cognitive function (%)
Length of stay in nursing home
 ≤ 3 years 227 (64.9) 136 (38.9) 91 (26) 0.117
 > 3 years 123 (35.1) 63 (18) 60 (17.1)
Gender
 Male 157 (44.9) 104 (29.7) 53 (15.1) 0.001
 Female 193 (55.1) 95 (27.1) 98 (28.0)
Religion
 Islam 303 (86.6) 169 (48.3) 134 (38.3) 0.522
 Christian 35 (10) 23 (6.6) 12 (3.4)
 Catholic 4 (1.1) 2 (0.6) 2 (0.6)
 Buddhism 5 (1.4) 3 (0.9) 2 (0.6)
 Hinduism 2 (0.6) 2 (0.6) 0 (0)
 Others 1 (0.3) 0 (0) 1 (0.3)
Ethnic group
 Javanese 135 (38.6) 68 (19.4) 67 (19.1) 0.044
 Sundanese 51 (14.6) 23 (6.6) 28 (8.0)
 Betawi 97 (27.7) 63 (18) 34 (9.7)
 Sumatra 44 (12.6) 28 (8) 16 (4.6)
 Chinese 9 (2.6) 7 (2) 2 (0.6)
 Other 14 (4) 10 (2.9) 4 (1.1)
Marital status
 Married 138 (39.4) 76 (21.7) 62 (17.7) 0.851
 Divorced dead 79 (22.6) 45 (12.9) 34 (9.7)
 Divorced alive 38 (10.9) 24 (6.9) 14 (4.0)
 Single 95 (27.1) 54 (15.4) 41 (11.7)
Education level
 Diplomas/higher education 7 (2.0) 6 (1.7) 1 (0.3) 0.000
 Graduated high school 47 (13.4) 33 (9.4) 14 (4.0)
 Graduated middle school 44 (12.6) 32 (9.1) 12 (3.4)
 Graduated from elementary school 107 (30.6) 65 (18.6) 42 (12.0)
 Did not graduate from elementary school 93 (26.6) 50 (14.3) 43 (12.3)
 No schooling 57 (14.9) 13 (3.7) 39 (11.1)
Disease history
 Hypertension (HT) 50 (14.3) 34 (9.7) 16 (4.6)
 Diabetes mellitus (DM) 6 (1.7) 6 (1.7) 0 (0)
 Cholesterol 2 (0.6) 1 (0.3) 1 (0.3)
 Heart failure 2 (0.6) 2 (0.6) 0 (0)
 Depression 5 (1.4) 3 (0.9) 2 (0.6)
 Mental disorders 65 (18.6) 28 (8.0) 37 (10.6)
 Strokes 8(2.3) 6 (1.7) 2 (0.6)
 Arthritis 14 (4.0) 11 (3.1) 3 (0.9)
 Cataracts 5 (1.4) 4 (1.1) 1 (0.3)
 Gastritis 3 (0.9) 3 (0.9) 0 (0)
Subjective memory complaints
 Very good 91 (24.5) 17 (19.1) 20 (5.3) 0.000
 Currently 183 (52.3) 111 (31.7) 72 (20.6)
 Bad 77 (22) 20 (5.7) 57 (16.3)
 Very bad 3 (0.9) 0 (0) 3(0,9)
Smoking
 Does not smoke 216 (61.7) 112 (32) 104 (29.7) 0.03
 Quit smoking 47 (13.4) 28 (8.0) 19 (5.4)
 Passive smoker 8 (2.3) 6 (1.7) 2 (0.6)
 Active smoker 79 (22.6) 53 (15.1) 26 (7.4)
Alcohol consumption
 Never 309 (88.3) 164 (46.9) 145 (41.4) 0.000
 Yes, once 38 (10.9) 32 (9.1) 6 (1.7)
 Yes, now 3 (0.9) 3 (0.9) 0 (0)
Consumption of fruits and vegetables
 Yes 317 (90.6) 187 (53.4) 130 (37.1) 0.013
 No 33 (9.4) 12 (3.4) 21 (6.0)
Employment history
 Formal/professional 10 (2.9) 8 (2.3) 2 (0.6) 0.045
 Informal 335 (95.7) 186 (53.1) 149 (42.6)
 Retired 5 (1.4) 5 (1.4) 0 (0)
Use of walking aids
 No 306 (87.4) 180 (51.4) 126 (36) 0.053
 Yes 44 (12.6) 19 (5.4) 25 (7.1)
Living arrangement
 Living with family 208 (59.4) 124 (35.4) 84 (24.0) 0.207
 Alone 142 (40.6) 75 (21.4) 67 (19.1)

MoCA: Montreal Cognitive Assessment.

Multivariate logistic regression

Table 3 indicates that the model accounts for 32.1% of the variance in MoCA scores and accurately classifies 72.6% of instances. This proportion suggests that the model was able to capture nearly one-third of the determinants of cognitive function among institutionalized elderly. While this is a meaningful contribution, it also indicates that other factors not included in the model may explain the remaining variability. Upon integrating all notable predictors, three variables were recognized as significantly correlated with cognitive levels: education level (OR = 0.686; p = 0.000), subjective memory complaints (OR = 0.293; p = 0.000), and alcohol intake (OR = 6.786; p = 0.000). Older persons who abstained from drinking were 6.786 times more likely to exhibit a high cognitive level than those who consumed alcohol. Furthermore, individuals with advanced education possessed a 0.686 probability of attaining elevated cognitive capabilities as they aged. Moreover, persons devoid of subjective memory complaints exhibited a 0.293 probability of possessing elevated cognitive levels in contrast to those who indicated bad or very poor memory complaints.

Table 3. Multivariate logistic regression: predictive factors for cognitive levels in older adults living in nursing homes.

Predictor variables B SE Wald p- value OR 95%CI Lower–Upper
Gender -0.196 0.304 0.415 0.520 0.822 0.453–1.493
Ethnic group -0.104 0.097 1.160 0.282 0.901 0.746–1.089
Education level -0.377 0.106 12.716 0.000 0.686 0.558–0.844
Disease history -0.004 0.021 0.038 0.846 0.996 0.955–1.039
Subjective memory complaints -1.228 0.205 5.950 0.000 0.293 0.196–0.437
Smoking -0.035 0.127 0.075 0.785 0.966 0.753–1.239
Alcohol consumption 1.915 0.527 13.203 0.000 6.786 2.416–19.062
Consumption of fruits and vegetables 0.423 0.467 0.823 0.364 1.527 0.612–3.813
Employment history -0.126 0.736 0.029 0.864 0.864 0.208–3.732

B: beta coefficients; SE: standard error; OR: odds ratio; CI: confident interval.

Discussion

This study revealed that older persons living in long-term care institutions (LTCIs) in Jakarta, Indonesia, displayed elevated MoCA scores, signifying enhanced cognitive performance. This study contradicts prior studies, which indicated that older persons in long-term care institutions are more prone to cognitive deterioration than those in community settings. 40 A nationally representative longitudinal study in China revealed that living arrangements significantly influence cognitive decline, with solitary living associated with accelerated cognitive deterioration in older men, whereas diverse living arrangements, including cohabitation with spouses and adult children, correlated with cognitive decline in older women. 41 Social isolation, loneliness, and restricted social involvement have been linked to reduced cognitive results in later life. 42 A recent meta-analysis indicated a broad spectrum of moderate cognitive impairment (MCI) prevalence among older persons in long-term care institutions, ranging from 4.0% to 87.4%, with a pooled prevalence of 21.2%. 43 The superior cognitive function noted in older adults in Jakarta may be ascribed to diverse social activities offered by these institutions, including entertainment gatherings, daily exercise, religious activities, and essential services, all of which improve quality of life in accordance with the Republic of Indonesia’s Social Welfare Law of 2012 concerning the care of older adults.

The research revealed educational attainment, self-reported memory issues, and alcohol intake as predictors of cognitive decline in elderly individuals residing in long-term care institutions. A meta-analysis indicated that each additional year of schooling decreases the risk of Alzheimer’s disease by 8% and dementia by 7%. 44 The association is exacerbated by age, as prior research suggests that schooling may alleviate racial and ethnic differences in cognitive performance among older adults. 45 Elevated educational attainment enhances cognitive reserve, postponing the clinical onset of Alzheimer’s disease until brain pathology is further advanced. 46 Thus, evaluating educational attainment in LTCIs can yield significant baseline data for the early identification of cognitive deterioration. 47, 48 Educational background cultivates cultural competency, augments reading proficiency, and develops problem-solving skills. 49

Subjective memory complaints (SMCs) are frequently observed in older persons and may signify possible cognitive impairment. 50 While several studies indicate that subjective memory complaints (SMCs) may not consistently align with objective cognitive impairments, 51 they may nonetheless be associated with anatomical alterations in the brain that facilitate cognitive deterioration. 52 A study in India identified correlations between tobacco use, smoking, alcohol intake, and cognitive impairment in older adults. 53 Alcohol intake has been demonstrated to induce brain damage by processes such as iron accumulation 54 and increased white matter hyperintensity volumes, 55 and is associated with Wernicke-Korsakoff syndrome, which negatively impacts memory and heightens the risk of cognitive impairment.

The study revealed that disease history was associated with cognitive levels, but it did not serve as a predictive variable. Cognitive performance can be affected by various factors, including age, gender, education, lifestyle choices, and the existence of chronic illnesses such as hypertension and diabetes. 56, 57 Studies have shown that elderly individuals with chronic conditions, especially hypertension or diabetes, may demonstrate diminished cognitive ability. 58 Furthermore, strokes may result in dementia, with severity influenced by factors like stroke site, volume, and pre-existing cognitive deficits. 59 The steady progression of cognitive decline, affected by multiple intricate factors, complicates this relationship. 60 Consequently, SMCs function as significant indicators of cognitive impairments and initial manifestations of Alzheimer’s disease and associated dementias.

To alleviate cognitive decline, it is essential for healthcare practitioners and family to cultivate trusting connections, encourage social engagement, and involve older persons in group activities. 37 Regular engagement in cognitive-stimulating activities, including adequate relaxation and sleep, is crucial, in addition to practices such as reading and media consumption. 61 In addition to these findings, this study provides novelty by focusing on institutionalized elderly in Indonesia, a population that has been rarely examined in prior regional research. While earlier studies have largely addressed community-dwelling older adults, our results demonstrate how the LTCI environment may shape cognitive outcomes. This contribution not only enriches the local evidence base but also offers insights relevant to global policy and practice, particularly in the design and evaluation of elderly care models in low- and middle-income countries.

This study’s limitations encompass variances in the cognitive status of older persons and its cross-sectional methodology, which constrains causal assumptions; thus, additional longitudinal investigations are essential for deeper insights. Moreover, increased sample sizes would improve analytical precision. Healthcare practitioners must prioritize initiatives that enhance cognitive function in older persons, while future research should concentrate on creating customized therapies for cognitive impairments associated with particular health problems.

Conclusions

This research revealed educational level, subjective memory issues, and alcohol use as significant predictors of cognitive performance in older persons residing in long-term care facilities. Moreover, variables like gender, ethnicity, medical history, tobacco use, dietary intake of fruits and vegetables, and occupational background were associated with cognitive performance, underscoring the necessity for customized healthcare interventions. These findings offer significant insights into the responses of older persons to cognitive impairment risk factors, allowing nurses and healthcare professionals to formulate more effective treatment regimens. Moreover, comprehending these links helps guide personalized interventions and promote equitable health policy, ultimately enhancing care for older individuals in Indonesia.

Ethical declaration

Prior to the investigation, this study has approval from the institutional review board (IRB) Committee of Universitas Indonesia with approval number of KET-168/UN2.F12.D1.2.1/PPM.00.02/2022 on June 21, 2022. This study adhered to the Declaration of Helsinki ( https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/). Written informed consent was obtained from participants prior joining the study and were apprised of the study’s objectives, benefits, and methods.

Acknowledgments

The authors thank to the Directorate of Research and Development, Universitas Indonesia under Cluster/Group/Research Centre Grant program in year 2022.

Funding Statement

This research received grant from the Directorate of Research and Development, Universitas Indonesia under Cluster/Group/Research Centre Grant program: NKB-049/UN2.RST/ HKP.05.00/2022.

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

[version 2; peer review: 3 approved

Data availability statement

The data behind this work can be obtained from the corresponding author (Ast. Prof. Faizul Hasan, RN, PhD, Email: faizul.h@chula.ac.th or Asc. Prof. Dr. Etty Rekawati, E-mail: rekawati@ui.ac.id) upon a reasonable request. Access to the data is restricted due to ethical issues and standards established by the Institutional Review Board (IRB) to safeguard participant confidentiality. Prospective data users must submit a written request detailing the intended purpose of data utilization and evidence of adherence to ethical norms. Approval will be contingent upon compliance with the stipulations set forth by the IRB, and applicants may be required to furnish institutional endorsement or present supplementary evidence to guarantee the proper use of the data.

Reporting guidelines

Zenodo Repository: STROBE checklist for ‘Cognitive Function and Its Determinants in Elderly Indonesians Residing in Long-Term Care: Insights from a Cross-Sectional Study’. https://doi.org/10.5281/zenodo.14048299 62

Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0).

References

  • 1. Indonesia Ministry of Health: InfoDatin “Lansia Berdaya, Bangsa Sejahtera.” Report. Jakarta: Kementerian Kesehatan RI;2024. Reference Source [Google Scholar]
  • 2. Indonesia Central Bureu of Statistics: BPS. Statistik Penduduk Lanjut Usia 2022. Jakarta:2024. Reference Source [Google Scholar]
  • 3. Higuchi M: Preventing non-communicable diseases in low-and middle-income countries: A literature review. The Malaysian Journal of Nursing (MJN). 2021;13(1):10–16. 10.31674/mjn.2021.v13i01.002 [DOI] [Google Scholar]
  • 4. Ramli R, Fadhillah MN: Faktor yang mempengaruhi fungsi kognitif pada lansia. Window of Nursing Journal. 2020;23–32. 10.33096/won.v1i1.246 [DOI] [Google Scholar]
  • 5. Al Rasyid I, Syafrita Y, Sastri S: Hubungan faktor risiko dengan fungsi kognitif pada lanjut usia kecamatan Padang Panjang Timur kota Padang Panjang. Jurnal Kesehatan Andalas. 2017;6(1):49–54. 10.25077/jka.v6i1.643 [DOI] [Google Scholar]
  • 6. Srivastava S, Sulaiman K, Drishti D, et al. : Factors associated with psychiatric disorders and treatment seeking behaviour among older adults in India. Sci. Rep. 2021;11(1):24085. 10.1038/s41598-021-03385-7 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 7. Reynolds CF, 3rd, Jeste DV, Sachdev PS, et al. : Mental health care for older adults: Rrecent advances and new directions in clinical practice and research. World Psychiatry. 2022;21(3):336–363. 10.1002/wps.20996 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8. Barahona AJ, Bursac Z, Veledar E, et al. : Relationship of blood and urinary manganese levels with cognitive function in elderly individuals in the United States by race/ethnicity, NHANES 2011–2014. Toxics. 2022;10(4):191. 10.3390/toxics10040191 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9. Susanty S, Effendy DS, Tosepu R, et al. : Anxiety and dementia in older adults in Indonesia. Paper presented at: 1st International Conference Medical and Health Science Halu Oleo (IMHO 2023). 2024. 10.2991/978-94-6463-392-4_15 [DOI]
  • 10. Rodríguez-Rey R, Garrido-Hernansaiz H, Collado S: Psychological impact and associated factors during the initial stage of the coronavirus (COVID-19) pandemic among the general population in Spain. Front. Psychol. 2020;11:1540. 10.3389/fpsyg.2020.01540 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11. Susanty S, Chung M-H, Chiu H-Y, et al. : Prevalence of loneliness and associated factors among community-dwelling older adults in Indonesia: A cross-sectional study. Int. J. Environ. Res. Public Health. 2022;19(8):4911. 10.3390/ijerph19084911 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12. Hutasuhut AF, Anggraini M, Angnesti R: Analisis fungsi kognitif pada lansia ditinjau dari jenis kelamin, riwayat pendidikan, riwayat penyakit, aktivitas fisik, aktivitas kognitif, dan keterlibatan sosial. Jurnal Psikologi Malahayati. 2020;2(1). 10.33024/jpm.v2i1.2428 [DOI] [Google Scholar]
  • 13. Murman DL: The impact of age on cognition. Semin. Hear. 2015;36:111–121. 10.1055/s-0035-1555115 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 14. Lin KA, Choudhury KR, Rathakrishnan BG, et al. : Marked gender differences in progression of mild cognitive impairment over 8 years. Alzheimers Dement. 2015;1(2):103–110. 10.1016/j.trci.2015.07.001 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 15. Wang J, Xiao LD, Wang K, et al. : Gender Differences in cognitive impairment among rural elderly in China. Int. J. Environ. Res. Public Health. 2020;17(10):3724. 10.3390/ijerph17103724 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16. Levine DA, Gross AL, Briceño EM, et al. : Sex differences in cognitive decline among US adults. JAMA Netw. Open. 2021;4(2):e210169–e210169. 10.1001/jamanetworkopen.2021.0169 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17. Brucki SMD, Nitrini R: Cognitive impairment in individuals with low educational level and homogeneous sociocultural background. Dement. Neuropsychol. 2014;8:345–350. 10.1590/S1980-57642014DN84000007 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18. Wang Y, Wang S, Zhu W, et al. : Reading activities compensate for low education-related cognitive deficits. Alzheimers Res. Ther. 2022;14(1):156. 10.1186/s13195-022-01098-1 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19. Lövdén M, Fratiglioni L, Glymour MM, et al. : Education and cognitive functioning across the life Span. Psychol. Sci. Public Interest. 2020;21(1):6–41. 10.1177/1529100620920576 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20. Ungvari Z, Toth P, Tarantini S, et al. : Hypertension-induced cognitive impairment: From pathophysiology to public health. Nat. Rev. Nephrol. 2021;17(10):639–654. 10.1038/s41581-021-00430-6 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 21. Canavan M, O’Donnell MJ: Hypertension and cognitive impairment: A review of mechanisms and key concepts. Front. Neurol. 2022;13:13. 10.3389/fneur.2022.821135 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 22. Mallorquí-Bagué N, Lozano-Madrid M, Toledo E, et al. : Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: Baseline cross-sectional analysis of the PREDIMED-plus study. Sci. Rep. 2018;8(1):16128. 10.1038/s41598-018-33843-8 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23. Munshi MN: Cognitive dysfunction in older adults with diabetes: What a clinician needs to know. Diabetes Care. 2017;40(4):461–467. 10.2337/dc16-1229 [DOI] [PubMed] [Google Scholar]
  • 24. Dove A, Shang Y, Xu W, et al. : The impact of diabetes on cognitive impairment and its progression to dementia. Alzheimers Dement. 2021;17(11):1769–1778. 10.1002/alz.12482 [DOI] [PubMed] [Google Scholar]
  • 25. Celutkiene J, Vaitkevicius A, Jakstiene S, et al. : Cognitive decline in heart failure: More attention is needed. Card. Fail. Rev. 2016;2(2):106–109. 10.15420/cfr.2016:19:2 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26. Goh FQ, Kong WKF, Wong RCC, et al. : Cognitive impairment in heart failure—A review. Biology. 2022;11(2):179. 10.3390/biology11020179 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 27. Momtaz YA, Hamid TA, Ibrahim R: Gastritis may boost odds of dementia. Am. J. Alzheimers Dis. Other Dement. 2014;29(5):452–456. 10.1177/1533317513518654 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 28. Han M-L, Chen J-H, Tsai M-K, et al. : Association between Helicobacter pylori infection and cognitive impairment in the elderly. J. Formos. Med. Assoc. 2018;117(11):994–1002. 10.1016/j.jfma.2017.11.005 [DOI] [PubMed] [Google Scholar]
  • 29. Erickson LD, White DS, Bassett P, et al. : Cognitive function in UK adults seropositive for Helicobacter pylori. PLoS One. 2023;18(6):e0286731. 10.1371/journal.pone.0286731 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 30. Colwell MJ, Tagomori H, Chapman S, et al. : Pharmacological targeting of cognitive impairment in depression: Recent developments and challenges in human clinical research. Transl. Psychiatry. 2022;12(1):484. 10.1038/s41398-022-02249-6 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 31. Lam RW, Kennedy SH, McIntyre RS, et al. : Cognitive dysfunction in major depressive disorder: Effects on psychosocial functioning and implications for treatment. Can. J. Psychiatry. 2014;59(12):649–654. 10.1177/070674371405901206 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 32. Zhu D, Al Mahmud A, Liu W: Social connections and participation among people with mild cognitive impairment: Barriers and recommendations. Front. Psych. 2023;14:14. 10.3389/fpsyt.2023.1188887 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 33. Lydon EA, Nguyen LT, Nie Q, et al. : An integrative framework to guide social engagement interventions and technology design for persons with mild cognitive impairment. Front. Public Health. 2022;9:9. 10.3389/fpubh.2021.750340 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 34. Bae SM: The mediating effect of physical function decline on the association between social activity and cognitive function in middle and older Korean adults: Analyzing ten years of data through multivariate latent growth modeling. Front. Psychol. 2020;11:11. 10.3389/fpsyg.2020.02008 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35. Bai A, Xu W, Lin Z: Prevalence and correlates of motoric cognitive risk syndrome in Chinese community-dwelling older adults. Front. Aging. 2022;3:3. 10.3389/fragi.2022.895138 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 36. Van Patten R, Iverson GL, Terry DP, et al. : Predictors and correlates of perceived cognitive decline in retired professional rugby league players. Front. Neurol. 2021;12:12. 10.3389/fneur.2021.676762 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 37. Mohanty M, Kumar P: Multi-component interventions in older adults having subjective Cognitive Decline (SCD)—a review article. Geriatrics. 2023;8(1):4. 10.3390/geriatrics8010004 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 38. Lestari S, Mistivani I, Rumende M, et al. : Comparison between mini mental state examination (MMSE) and Montreal cognitive assessment Indonesian version (MoCA-Ina) as an early detection of cognitive impairments in post-stroke patients. J. Phys. Conf. Ser. 2017;884:012153. 10.1088/1742-6596/884/1/012153 [DOI] [Google Scholar]
  • 39. Rambe AS, Fitri FI: Correlation between the Montreal Cognitive Assessment-Indonesian Version (Moca-INA) and the Mini-Mental State Examination (MMSE) in elderly. Open Access Maced. J. Med. Sci. 2017;5(7):915–919. 10.3889/oamjms.2017.202 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 40. Setiyani R, Iskandar A: Cognitive impairment among older adults living in the community and in nursing home in Indonesia: A pilot study. Dement. Neuropsychol. 2022;16:347–353. 10.1590/1980-5764-DN-2022-0012 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 41. Yu Y, Lv J, Liu J, et al. : Association between living arrangements and cognitive decline in older adults: A nationally representative longitudinal study in China. BMC Geriatr. 2022;22(1):843. 10.1186/s12877-022-03473-x [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 42. Evans IEM, Llewellyn DJ, Matthews FE, et al. : Living alone and cognitive function in later life. Arch. Gerontol. Geriatr. 2019;81:222–233. 10.1016/j.archger.2018.12.014 [DOI] [PubMed] [Google Scholar]
  • 43. Chen P, Cai H, Bai W, et al. : Global prevalence of mild cognitive impairment among older adults living in nursing homes: A meta-analysis and systematic review of epidemiological surveys. Transl. Psychiatry. 2023;13(1):88. 10.1038/s41398-023-02361-1 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 44. Maccora J, Peters R, Anstey KJ: What does (low) education mean in terms of dementia risk? A systematic review and meta-analysis highlighting inconsistency in measuring and operationalising education. SSM - Population Health. 2020;12:100654. 10.1016/j.ssmph.2020.100654 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 45. Díaz-Venegas C, Downer B, Langa KM, et al. : Racial and ethnic differences in cognitive function among older adults in the USA. Int. J. Geriatr. Psychiatry. 2016;31(9):1004–1012. 10.1002/gps.4410 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 46. Hwangbo S, Kim YJ, Park YH, et al. : Relationships between educational attainment, hypertension, and amyloid negative subcortical vascular dementia: The brain-battering hypothesis. Front. Neurosci. 2022;16. 10.3389/fnins.2022.934149 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 47. Williams BD, Pendleton N, Chandola T: Does the association between cognition and education differ between older adults with gradual or rapid trajectories of cognitive decline? Aging Neuropsychol. Cognit. 2022;29(4):666–686. 10.1080/13825585.2021.1889958 [DOI] [PubMed] [Google Scholar]
  • 48. Gonçalves NG, Avila JC, Bertola L, et al. : Education and cognitive function among older adults in Brazil and Mexico. Alzheimers Dement. 2023;15(3):e12470. 10.1002/dad2.12470 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 49. Alley D, Suthers K, Crimmins E: Education and cognitive decline in older Americans:Results from the AHEAD Sample. Res. Aging. 2007;29(1):73–94. 10.1177/0164027506294245 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 50. Chu C-S, Sun IW, Begum A, et al. : The association between subjective memory complaint and objective cognitive function in older people with previous major depression. PLoS One. 2017;12(3):e0173027. 10.1371/journal.pone.0173027 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 51. Mitchell AJ: Is it time to separate subjective cognitive complaints from the diagnosis of mild cognitive impairment? Age Ageing. 2008;37(5):497–499. 10.1093/ageing/afn147 [DOI] [PubMed] [Google Scholar]
  • 52. Dhana A, DeCarli C, Dhana K, et al. : Association of subjective memory complaints with white matter hyperintensities and cognitive decline among older adults in Chicago, Illinois. JAMA Netw. Open. 2022;5(4):e227512–e227512. 10.1001/jamanetworkopen.2022.7512 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 53. Muhammad T, Govindu M, Srivastava S: Relationship between chewing tobacco, smoking, consuming alcohol and cognitive impairment among older adults in India: A cross-sectional study. BMC Geriatr. 2021;21(1):85. 10.1186/s12877-021-02027-x [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 54. Medical News Today: Drinking just 3 cans of beer a week may be linked to cognitive decline. 2024. Reference Source
  • 55. Devere R: The cognitive consequences of alcohol use. 2024. Reference Source
  • 56. Andriyanto A, Rekawati E, Rahmadiyah DC: Increasing knowledge, attitudes, skills, and glucose control in type-2 diabetic patients through EMAS interventions. 2019;9(2):10. 10.14710/nmjn.v9i2.22989 [DOI] [Google Scholar]
  • 57. Rahmayanti Y: Hubungan lama menderita hipertensi dengan penurunan fungsi kognitif pada lansia. Jurnal Aceh Medika. 2018;2(2):241–246. Reference Source [Google Scholar]
  • 58. Kim J, Park E, An M: The cognitive impact of chronic diseases on functional capacity in community-dwelling adults. J. Nurs. Res. 2019;27(1):e3–e8. 10.1097/jnr.0000000000000272 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 59. Pessotti CFC, Fonseca LC, Tedrus GMAS, et al. : Family caregivers of elderly with dementia relationship between religiosity, resilience, quality of life and burden. Dement. Neuropsychol. 2018;12:408–414. 10.1590/1980-57642018dn12-040011 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 60. Wilson RS, Segawa E, Boyle PA, et al. : The natural history of cognitive decline in Alzheimer’s disease. Psychol. Aging. 2012;27(4):1008–1017. 10.1037/a0029857 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 61. Sanjuán M, Navarro E, Calero MD: Effectiveness of cognitive interventions in older adults: A review. Eur. J. Investig. Health Psychol. Educ. 2020;10(3):876–898. 10.3390/ejihpe10030063 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 62. Hasan F: strobe checklist. Zenodo. 2024. 10.5281/zenodo.14048299 [DOI]
F1000Res. 2025 Aug 19. doi: 10.5256/f1000research.174085.r395149

Reviewer response for version 1

Saranya Pimolkatekul 1

This is a well-written cross-sectional study that investigates the relationship between cognitive function and associated risk factors among elderly Indonesians residing in long-term care settings. The study addresses a relevant public health concern and offers useful descriptive data. However, there are a few minor issues that should be considered to improve the clarity and impact of the paper.

Firstly, the background would benefit from a clearer articulation of the knowledge gap that this study aims to address. Including a brief summary of what previous studies have not covered particularly in the context of elderly residents in long-term care would better highlight the importance and novelty of this research. Secondly, the manuscript uses various terms interchangeably, such as elderly, older people, and long-term care, long-term care facilities, long-term care institutions. This inconsistency could cause confusion for readers, especially as these terms may have different definitions. To enhance clarity, it is recommended to use consistent terminology throughout the paper. Lastly, while the introduction effectively provides prevalence data and outlines the factors related to cognitive function, it lacks essential details about the study setting and a more explicit justification for focusing on the long-term care population. Clarifying why this particular population and setting were selected would strengthen the rationale for the study.

Major Comments:

Results (Tables): Please clarify and recheck all the numerical values presented in the tables. For example, there are inconsistencies between Table 1 and Table 2 regarding variables such as education level, subjective memory complaints, and living arrangements. In particular, the data on disease history raises concern. Although the total sample size is reported as 350, the frequencies listed appear to account for only 308 participants. It is also unclear how the 148 participants (42.3%) reporting good health are included in this count. Additionally, some p-values appear to be missing in Table 2. Please ensure that all relevant statistical results are reported and that values are consistent across tables.

Minor Comments:

Study Participants: Please provide more context to clarify the inclusion and exclusion criteria, as well as whether a sample size calculation was conducted and how the final sample size was determined.

Tables: Table 1 appears to present similar information to Table 2, which already provides the detailed results. To avoid redundancy and improve clarity, consider removing Table 1 and retaining only Table 2.

The conclusion section should more clearly emphasize the main findings of the study, particularly those that are statistically and/or clinically significant. Highlighting the key results will help reinforce the contributions of the study. Additionally, the conclusion should briefly acknowledge the study’s limitations such as the cross-sectional design, potential selection bias, or limited generalizability to provide context for interpreting the results. Including these limitations can also guide future research by suggesting areas that need further exploration or different methodological approaches.

Is the work clearly and accurately presented and does it cite the current literature?

Yes

If applicable, is the statistical analysis and its interpretation appropriate?

I cannot comment. A qualified statistician is required.

Are all the source data underlying the results available to ensure full reproducibility?

Partly

Is the study design appropriate and is the work technically sound?

Yes

Are the conclusions drawn adequately supported by the results?

Yes

Are sufficient details of methods and analysis provided to allow replication by others?

Partly

Reviewer Expertise:

Diabetes Mellitus, Frailty, Older adults

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.

F1000Res. 2025 Aug 14. doi: 10.5256/f1000research.174085.r395145

Reviewer response for version 1

Rian Adi Pamungkas 1

The topic is highly relevant in light of global population aging and the increasing burden of cognitive decline in older adults. The use of the MoCA-Ina, a culturally adapted and validated instrument, is appropriate and strengthens internal validity. However, several areas require further clarification, elaboration, and strengthening to enhance the manuscript’s scientific rigor and impact

1. While the study highlights a specific population (elderly in LTCIs), the novelty could be more explicitly framed in the Introduction and Discussion. How does this study differ significantly from prior regional studies? How does it inform global policy/practice?

2. The authors used univariate logistic regression followed by multivariate logistic regression. However, a rationale for the model-building strategy is missing. Were interaction effects or multicollinearity assessed?

3. The explained variance in the logistic regression model (R² = 32.1%) could benefit from more contextual interpretation.

Is the work clearly and accurately presented and does it cite the current literature?

Yes

If applicable, is the statistical analysis and its interpretation appropriate?

Yes

Are all the source data underlying the results available to ensure full reproducibility?

Yes

Is the study design appropriate and is the work technically sound?

Yes

Are the conclusions drawn adequately supported by the results?

Yes

Are sufficient details of methods and analysis provided to allow replication by others?

Yes

Reviewer Expertise:

Gerontology nursing

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.

F1000Res. 2025 Aug 14. doi: 10.5256/f1000research.174085.r395151

Reviewer response for version 1

Made Satya Nugraha Gautama 1

The study addresses an important topic: cognitive function in elderly Indonesians in long-term care. This is a growing population with specific needs. The manuscript is generally well-written and organized.

The findings have potential implications for healthcare practices in long-term care settings.

However I have several comments/questions should be addressed below:

- Provide more detail about the "major Long-Term Care Institutions in Jakarta." How many institutions were included?

- "Comprehensive sampling method" is vague. Was it a census of all eligible residents in the selected facilities? Or a stratified random sample? If not random sampling, explain potential biases.

- "Older people (≥60 years) devoid of eyesight or hearing impairments" – Why were individuals with eyesight or hearing impairments excluded?

I believe that addressing these points, particularly in the Methods section, will strengthen the manuscript and enhance its overall impact.

Is the work clearly and accurately presented and does it cite the current literature?

Yes

If applicable, is the statistical analysis and its interpretation appropriate?

Yes

Are all the source data underlying the results available to ensure full reproducibility?

Yes

Is the study design appropriate and is the work technically sound?

Yes

Are the conclusions drawn adequately supported by the results?

Yes

Are sufficient details of methods and analysis provided to allow replication by others?

Yes

Reviewer Expertise:

Adult Nursing, Palliative, Quantitative Research

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.

F1000Res. 2025 Jul 24. doi: 10.5256/f1000research.174085.r390862

Reviewer response for version 1

Yuni Asri 1

This robust study used appropriate tools (MoCA-Ina) and valid analyses. To enhance clarity and reproducibility, authors should categorize variables (e.g., age, education), justify their inclusion in regression models, and detail data distribution and missing data handling in tables or text. These improvements would boost transparency and strengthen the study’s reliability.

Is the work clearly and accurately presented and does it cite the current literature?

Yes

If applicable, is the statistical analysis and its interpretation appropriate?

Yes

Are all the source data underlying the results available to ensure full reproducibility?

Yes

Is the study design appropriate and is the work technically sound?

Yes

Are the conclusions drawn adequately supported by the results?

Yes

Are sufficient details of methods and analysis provided to allow replication by others?

Yes

Reviewer Expertise:

public health, prevalence study, epidiomilogy.

I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard.

References

  • 1. : Global, regional, and national burden of stroke and its risk factors, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet Neurology .2024;23(10) : 10.1016/S1474-4422(24)00369-7 973-1003 10.1016/S1474-4422(24)00369-7 [DOI] [PMC free article] [PubMed] [Google Scholar]

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Data Availability Statement

    The data behind this work can be obtained from the corresponding author (Ast. Prof. Faizul Hasan, RN, PhD, Email: faizul.h@chula.ac.th or Asc. Prof. Dr. Etty Rekawati, E-mail: rekawati@ui.ac.id) upon a reasonable request. Access to the data is restricted due to ethical issues and standards established by the Institutional Review Board (IRB) to safeguard participant confidentiality. Prospective data users must submit a written request detailing the intended purpose of data utilization and evidence of adherence to ethical norms. Approval will be contingent upon compliance with the stipulations set forth by the IRB, and applicants may be required to furnish institutional endorsement or present supplementary evidence to guarantee the proper use of the data.

    Reporting guidelines

    Zenodo Repository: STROBE checklist for ‘Cognitive Function and Its Determinants in Elderly Indonesians Residing in Long-Term Care: Insights from a Cross-Sectional Study’. https://doi.org/10.5281/zenodo.14048299 62

    Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0).


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