Abstract
Immature mice were treated for up to 8 weeks with daily doses of triamcinolone diacetate. The humerus was studied radiographically at regular intervals. Roentgenographic measurements included midshaft width, medullary width, cortical thickness and total length. By the time of the tenth injection significant cortical bone loss was noted, followed by increased width of the medullary cavity and osteoporosis. An initial phase of active endosteal bone resorption was replaced by a prolonged steady state which extended throughout the experimental period. Possible explanations for the above findings are discussed.
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- BARNETT E., NORDIN B. E. The radiological diagnosis of osteoporosis: a new approach. Clin Radiol. 1960 Jul;11:166–174. doi: 10.1016/s0009-9260(60)80012-8. [DOI] [PubMed] [Google Scholar]
- Dequeker J. Bone and ageing. Ann Rheum Dis. 1975 Feb;34(1):100–115. doi: 10.1136/ard.34.1.100. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Duncan H. Bone dynamics of rheumatoid arthritis treated with adrenal corticosteroids. Arthritis Rheum. 1967 Jun;10(3):216–227. doi: 10.1002/art.1780100307. [DOI] [PubMed] [Google Scholar]
- Exton-Smith A. N., Millard P. H., Payne P. R., Wheeler E. F. Pattern of development and loss of bone with age. Lancet. 1969 Nov 29;2(7631):1154–1157. doi: 10.1016/s0140-6736(69)92483-0. [DOI] [PubMed] [Google Scholar]
- Feldman D., Dziak R., Koehler R., Stern P. Cytoplasmic glucocorticoid binding proteins in bone cells. Endocrinology. 1975 Jan;96(1):29–36. doi: 10.1210/endo-96-1-29. [DOI] [PubMed] [Google Scholar]
- Frost H. M. Selected recent vistas in bone pathology. Pathol Annu. 1974;9(0):421–439. [PubMed] [Google Scholar]
- Hahn T. J., Boisseau V. C., Avioli L. V. Effect of chronic corticosteroid administration on diaphyseal and metaphyseal bone mass. J Clin Endocrinol Metab. 1974 Aug;39(2):274–282. doi: 10.1210/jcem-39-2-274. [DOI] [PubMed] [Google Scholar]
- Jowsey J., Riggs B. L. Bone formation in hypercortisonism. Acta Endocrinol (Copenh) 1970 Jan;63(1):21–28. doi: 10.1530/acta.0.0630021. [DOI] [PubMed] [Google Scholar]
- Saville P. D. A quantitative approach to simple radiographic diagnosis of osteoporosis: its application to the osteoporosis of rheumatoid arthritis. Arthritis Rheum. 1967 Oct;10(5):416–422. doi: 10.1002/art.1780100503. [DOI] [PubMed] [Google Scholar]
- Silbermann M. Experimentally induced osteoarthrosis in the temporomandibular joint of the mouse. Acta Anat (Basel) 1976;96(1):9–24. doi: 10.1159/000144658. [DOI] [PubMed] [Google Scholar]
- Silbermann M., Kleinhaus U., Livne E., Kedar T. Retardation of bone growth in triamcinolone-treated mice. J Anat. 1976 Jul;121(Pt 3):515–535. [PMC free article] [PubMed] [Google Scholar]
- Thompson J. S., Urist M. R. Effects of cortisone on bone metabolism in intact and thyroidectomized rabbits. Calcif Tissue Res. 1973 Oct 23;13(3):197–215. doi: 10.1007/BF02015410. [DOI] [PubMed] [Google Scholar]