Skip to main content
NCBI home page
Journal of Anatomy logoLink to Journal of Anatomy
. 1978 Feb;125(Pt 2):223–230.

A teased-fibre study of the median nerves of vitamin B12-depleted baboons.

J F Knowles
PMCID: PMC1235591  PMID: 415028

Abstract

Isolated nerve fibres of the median nerve of normal baboons and baboons kept on diets deficient in vitamin B12, and supplemented with potassium cyanide and potassium thiocyanate injections, were examined by the teased-fibre technique. Regression lines of internodal length on fibre diameter were obtained. Small differences between the groups were apparent but were of uncertain significance. There was occasional evidence of segmental demyelination and Wallerian degeneration but this was not characteristic of any particular group.

Full text

PDF
223

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnold N., Harriman D. G. The incidence of abnormality in control human peripheral nerves studied by single axon dissection. J Neurol Neurosurg Psychiatry. 1970 Feb;33(1):55–61. doi: 10.1136/jnnp.33.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CAVANAGH J. B., JACOBS J. M. SOME QUANTITATIVE ASPECTS OF DIPHTHERITIC NEUROPATHY. Br J Exp Pathol. 1964 Jun;45:309–322. [PMC free article] [PubMed] [Google Scholar]
  3. Chopra J. S., Hurwitz L. J. Internodal length of sural nerve fibres in chronic occlusive vascular disease. J Neurol Neurosurg Psychiatry. 1967 Jun;30(3):207–214. doi: 10.1136/jnnp.30.3.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dyck P. J., Gutrecht J. A., Bastron J. A., Karnes W. E., Dale A. J. Histologic and teased-fiber measurements of sural nerve in disorders of lower motor and primary sensory neurons. Mayo Clin Proc. 1968 Feb;43(2):81–123. [PubMed] [Google Scholar]
  5. Dyck P. J., Lambert E. H. Dissociated sensation in amylidosis. Compound action potential, quantitative histologic and teased-fiber, and electron microscopic studies of sural nerve biopsies. Arch Neurol. 1969 May;20(5):490–507. doi: 10.1001/archneur.1969.00480110054005. [DOI] [PubMed] [Google Scholar]
  6. Eames R. A., Lange L. S. Clinical and pathological study of ischaemic neuropathy. J Neurol Neurosurg Psychiatry. 1967 Jun;30(3):215–226. doi: 10.1136/jnnp.30.3.215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gutrecht J. A., Dyck P. J. Segmental demyelinization in peroneal muscular atrophy: nerve fibers teased from sural nerve biopsy specimens. Mayo Clin Proc. 1966 Nov;41(11):775–777. [PubMed] [Google Scholar]
  8. Kark J. A., Victor M., Hines J. D., Harris J. W. Nutritional vitamin B12 deficiency in rhesus monkeys. Am J Clin Nutr. 1974 May;27(5):470–478. doi: 10.1093/ajcn/27.5.470. [DOI] [PubMed] [Google Scholar]
  9. Knowles J. F. An electron microscope study of the unmyelinated nerve fibres in normal baboon median nerves: negative effect of vitamin-B12 depletion. J Anat. 1976 Jul;121(Pt 3):461–474. [PMC free article] [PubMed] [Google Scholar]
  10. Lascelles R. G., Thomas P. K. Changes due to age in internodal length in the sural nerve in man. J Neurol Neurosurg Psychiatry. 1966 Feb;29(1):40–44. doi: 10.1136/jnnp.29.1.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Oxnard C. E., Smith W. T. Neurological degeneration and reduced serum vitamin B12-levels in captive monkeys. Nature. 1966 Apr 30;210(5035):507–509. doi: 10.1038/210507a0. [DOI] [PubMed] [Google Scholar]
  12. Oxnard C. E., Smith W. T., Torres I. Vitamin B12 deficiency in captive monkeys and its effect on the nervous system and the blood. Lab Anim. 1970 Apr;4(1):1–12. doi: 10.1258/002367770781036526. [DOI] [PubMed] [Google Scholar]
  13. Siddons R. C. The experimental production of vitamin B12 deficiency in the baboon (Papio cynocephalus). A 2-year study. Br J Nutr. 1974 Sep;32(2):219–228. doi: 10.1079/bjn19740075. [DOI] [PubMed] [Google Scholar]
  14. THOMAS P. K. Growth changes in the myelin sheath of peripheral nerve fibres in fishes. Proc R Soc Lond B Biol Sci. 1955 Mar 15;143(912):380–391. doi: 10.1098/rspb.1955.0018. [DOI] [PubMed] [Google Scholar]
  15. Torres I., Smith W. T., Oxnard C. E. Peripheral neuropathy associated with vitamin-B 12 deficience in captive monkeys. J Pathol. 1971 Oct;105(2):125–146. doi: 10.1002/path.1711050206. [DOI] [PubMed] [Google Scholar]
  16. Torres I., Smith W. T., Oxnard C. Degeneration of the peripheral and central nervous system in vitamin-B12-deficient monkeys. Experientia. 1969 Mar 15;25(3):273–275. doi: 10.1007/BF02034387. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Anatomy are provided here courtesy of Anatomical Society of Great Britain and Ireland

RESOURCES