Abstract
The functional activity of the epithelial cells of the intestinal folds of Xenopus was analysed histochemically. There is a gradient of increasing absorptive, digestive and secretory activity from the trough regions to the crests of the longitudinal folds. The differences in functional activity correspond to differences in structural complexity, and confirm the existence of a more specialized population of cells at the fold crests and a less specialized population at the fold troughs, analogous to mammalian villous and crypt cells respectively.
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- BARKA T. ELECTRON HISTOCHEMICAL LOCALIZATION OF ACID PHOSPHATASE ACTIVITY IN THE SMALL INTESTINE OF MOUSE. J Histochem Cytochem. 1964 Apr;12:229–238. doi: 10.1177/12.4.229. [DOI] [PubMed] [Google Scholar]
- Fortin-Magana R., Hurwitz R., Herbst J. J., Kretchmer N. Intestinal enzymes: indicators of proliferation and differentiation in the jejunum. Science. 1970 Mar 20;167(3925):1627–1628. doi: 10.1126/science.167.3925.1627. [DOI] [PubMed] [Google Scholar]
- Galjaard H., Bootsma D. The regulation of cell proliferation and differentiation in intestinal epithelium. II. A quantitative histochemical and autoradiographic study after low doses of x-irradiation. Exp Cell Res. 1969 Nov;58(1):79–92. doi: 10.1016/0014-4827(69)90118-9. [DOI] [PubMed] [Google Scholar]
- Galjaard H., Buys J., van Duuren M., Giesen J. A quantitative histochemical study of intestinal mucosa after x-irradiation. J Histochem Cytochem. 1970 Apr;18(4):291–301. doi: 10.1177/18.4.291. [DOI] [PubMed] [Google Scholar]
- Gauthier G. F., Landis S. C. The relationship of ultrastructural and cytochemical features to absorptive activity in the goldfish intestine. Anat Rec. 1972 Apr;172(4):675–701. doi: 10.1002/ar.1091720408. [DOI] [PubMed] [Google Scholar]
- HSU L., TAPPEL A. L. LYSOSOMAL ENZYMES OF RAT INTESTINAL MUCOSA. J Cell Biol. 1964 Nov;23:233–240. doi: 10.1083/jcb.23.2.233. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hugon J. S., Borgers M. Fine structural localization of three lysosomal enzymes and nonspecific alkaline phosphatase in the villus of the human duodenum. Gastroenterology. 1968 Nov;55(5):608–618. [PubMed] [Google Scholar]
- Hugon J., Borgers M. Fine structural localization of lysosomal enzymes in the absorbing cells of the duodenal mucosa of the mouse. J Cell Biol. 1967 Apr;33(1):212–218. doi: 10.1083/jcb.33.1.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Imondi A. R., Balis M. E., Lipkin M. Changes in enzyme levels accompanying differentiation of intestinal epithelial cells. Exp Cell Res. 1969 Dec;58(2):323–330. doi: 10.1016/0014-4827(69)90512-6. [DOI] [PubMed] [Google Scholar]
- LADMAN A. J., PADYKULA H. A., STRAUSS E. W. A morphological study of fat transport in the normal human jejunum. Am J Anat. 1963 May;112:389–419. doi: 10.1002/aja.1001120307. [DOI] [PubMed] [Google Scholar]
- LEHRER G. M., ORNSTEIN L. A diazo coupling method for the electron microscopic localization of cholinesterase. J Biophys Biochem Cytol. 1959 Dec;6:399–406. doi: 10.1083/jcb.6.3.399. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lipkin M. Proliferation and differentiation of gastrointestinal cells. Physiol Rev. 1973 Oct;53(4):891–915. doi: 10.1152/physrev.1973.53.4.891. [DOI] [PubMed] [Google Scholar]
- MOE H., ROSTGAARD J., BEHNKE O. ON THE MORPHOLOGY AND ORIGIN OF VIRGIN LYSOSOMES IN THE INTESTINAL EPITHELIUM OF THE RAT. J Ultrastruct Res. 1965 Apr;12:396–403. doi: 10.1016/s0022-5320(65)80107-1. [DOI] [PubMed] [Google Scholar]
- McAvoy J. W., Dixon K. E. Cell specialization in the small intestinal epithelium of adult Xenopus laevis: structural aspects. J Anat. 1978 Jan;125(Pt 1):155–169. [PMC free article] [PubMed] [Google Scholar]
- McAvoy J. W., Dixon K. E., Marshall J. A. Effects of differences in mitotic activity, stage of cell cycle, and degree of specialization of donor cells on nuclear transplantation in Xenopus laevis. Dev Biol. 1975 Aug;45(2):330–339. doi: 10.1016/0012-1606(75)90070-6. [DOI] [PubMed] [Google Scholar]
- McAvoy J. W., Dixon K. E. Nuclear transplantation from specialized and unspecialized gut epithelial cells of adult Xenopus laevis. J Exp Zool. 1974 Aug;189(2):243–248. doi: 10.1002/jez.1401890212. [DOI] [PubMed] [Google Scholar]
- PADYKULA H. A. Recent functional interpretations of intestinal morphology. Fed Proc. 1962 Nov-Dec;21:873–879. [PubMed] [Google Scholar]
- Strum J. M., Karnovsky M. J. Ultrastructural localization of peroxidase in submaxillary acinar cells. J Ultrastruct Res. 1970 May;31(3):323–336. doi: 10.1016/s0022-5320(70)90135-8. [DOI] [PubMed] [Google Scholar]




