Abstract
This preliminary study evaluated phenoxymethyl penicillin (Penicillin V) as an alternative to parenteral administration of penicillin in horses. Penicillin V was administered orally to five horses at two different doses and plasma levels of the drug were determined at timed intervals. The results were evaluated by regression analysis. Following the administration of penicillin V at a dose of 66,000 IU/kg or 110,000 IU/kg, the mean peak plasma levels obtained were 1.55 micrograms/mL and 2.34 micrograms/mL respectively. A plasma level two to four times above the minimal inhibitory concentration level of Streptococcus equi and Streptococcus zooepidemicus was maintained for 325 minutes at 66,000 IU/kg and 349 minutes at 110,000 IU/kg. Penicillin V given orally was thus shown to be an acceptable alternative to parenteral administration of penicillin in the horse.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BUNN P. A. Phenoxymethyl penicillin (V): pharmacologic observations. J Lab Clin Med. 1956 Sep;48(3):392–398. [PubMed] [Google Scholar]
- CUNLIFFE A. C., RINSLER M. G. Penicillin by mouth; laboratory studies of absorption of penicillin V. Lancet. 1956 Aug 18;271(6938):328–330. doi: 10.1016/s0140-6736(56)92190-0. [DOI] [PubMed] [Google Scholar]
- English P. B. Newer penicillins in veterinary practice. Aust Vet J. 1968 Apr;44(4):174–178. doi: 10.1111/j.1751-0813.1968.tb09070.x. [DOI] [PubMed] [Google Scholar]
- Jalling B., Malmborg A. S., Lindman A., Boréus L. O. Evaluation of a micromethod for determination of antibiotic concentrations in plasma. Eur J Clin Pharmacol. 1972 Jun;4(3):150–157. doi: 10.1007/BF00561138. [DOI] [PubMed] [Google Scholar]
- Love D. N., Rose R. J., Martin I. C., Bailey M. Serum levels of amoxycillin following its oral administration to thoroughbred foals. Equine Vet J. 1981 Jan;13(1):53–55. doi: 10.1111/j.2042-3306.1981.tb03452.x. [DOI] [PubMed] [Google Scholar]
- McDonald P. J., Craig W. A., Kunin C. M. Persistent effect of antibiotics on Staphylococcus aureus after exposure for limited periods of time. J Infect Dis. 1977 Feb;135(2):217–223. doi: 10.1093/infdis/135.2.217. [DOI] [PubMed] [Google Scholar]
- Ndiritu C. G., Enos L. R. Adverse reactions to drugs in a veterinary hospital. J Am Vet Med Assoc. 1977 Aug 15;171(4):335–339. [PubMed] [Google Scholar]