Abstract
3-Acetyldeoxynivalenol was incorporated into a semisynthetic diet at levels of 2.5, 5, 10 or 20 ppm and fed to mice for up to 48 days. Body weights and feed consumption were determined, and blood samples for hematological evaluation were taken. Selected tissues were examined microscopically and the humoral immune response was assessed using the Jerne plaque assay. 3-Acetyldeoxynivalenol caused a dose-related depressed feed consumption within the first seven days and reduced body weight until day 14 when fed at levels up to 10 ppm. When fed at a level of 20 ppm, an initial depression in body weight gain and a general malaise were followed by a return to normal. At necropsy, no macroscopic or microscopic lesions could be found. The immune response was not significantly affected after seven or 14 days, but at 21 days, a dose-dependent enhanced response was observed. The findings indicate that, after an initial period of reduced feed intake, animals are apparently able to overcome the toxic effects of 3-acetyldeoxynivalenol.
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- Côté L. M., Reynolds J. D., Vesonder R. F., Buck W. B., Swanson S. P., Coffey R. T., Brown D. C. Survey of vomitoxin-contaminated feed grains in midwestern United States, and associated health problems in swine. J Am Vet Med Assoc. 1984 Jan 15;184(2):189–192. [PubMed] [Google Scholar]
- Hayes M. A., Bellamy J. E., Schiefer H. B. Subacute toxicity of dietary T-2 toxin in mice: morphological and hematological effects. Can J Comp Med. 1980 Apr;44(2):203–218. [PMC free article] [PubMed] [Google Scholar]
- Hayes M. A., Schiefer H. B. Subacute toxicity of Dietary T-2 toxin in mice: influence of protein nutrition. Can J Comp Med. 1980 Apr;44(2):219–228. [PMC free article] [PubMed] [Google Scholar]
- Jerne N. K., Henry C., Nordin A. A., Fuji H., Koros A. M., Lefkovits I. Plaque forming cells: methodology and theory. Transplant Rev. 1974;18:130–191. doi: 10.1111/j.1600-065x.1974.tb01588.x. [DOI] [PubMed] [Google Scholar]
- McLIMANS W. F., DAVIS E. V., GLOVER F. L., RAKE G. W. The submerged culture of mammalian cells; the spinner culture. J Immunol. 1957 Nov;79(5):428–433. [PubMed] [Google Scholar]
- Schiefer H. B., Nicholson S., Kasali O. B., Hancock D. S., Greenhalgh R. Pathology of acute 3-acetyldeoxynivalenol toxicity in mice. Can J Comp Med. 1985 Jul;49(3):315–318. [PMC free article] [PubMed] [Google Scholar]