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. 1995 Dec;69(6):2661–2669. doi: 10.1016/S0006-3495(95)80136-0

Hydration of the DNA bases is local.

B Schneider 1, H M Berman 1
PMCID: PMC1236503  PMID: 8599672

Abstract

Ordered hydration sites were determined for the nucleotide bases in B-type conformations using the crystal structure data on 14 B-DNA decamer structures. A method of density representation was extended so that positions, occupancies, and distributions of the hydration sites were predicted around a B-DNA double helix by a method analogous to crystallographic refinement. The predicted hydration sites correctly reproduce the main features of hydration around the B-DNA dodecamer. In contrast to the previous observations, the newly available crystal data show the same extent of hydration of guanine and adenine, and of cytosine and thymine.

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Selected References

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