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. 1986 Jun;55(6):596–598. doi: 10.1136/hrt.55.6.596

Reversible renal failure after combined treatment with enalapril and frusemide in a patient with congestive heart failure.

C Funck-Brentano, G Chatellier, J M Alexandre
PMCID: PMC1236768  PMID: 3013264

Abstract

A patient with congestive heart failure and moderate renal insufficiency developed severe reversible non-oliguric renal failure while on frusemide and enalapril. Renal failure developed when enalapril was given in the presence of pronounced sodium depletion. When positive sodium balance was restored the plasma creatinine concentration began to fall while angiotensin converting enzyme inhibition remained effective and blood pressure was stable. These observations suggest that the degree of sodium depletion plays an important role in the tendency for angiotensin converting enzyme inhibitors to induce renal failure in patients with congestive heart failure and moderate renal insufficiency. Restoration of a positive sodium balance promotes the recovery of renal function after the combined administration of angiotensin converting enzyme inhibitors and diuretics.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aldigier J. C., Plouin P. F., Guyene T. T., Thibonnier M., Corvol P., Menard J. Comparison of the hormonal and renal effects of captopril in severe essential and renovascular hypertension. Am J Cardiol. 1982 Apr 21;49(6):1447–1452. doi: 10.1016/0002-9149(82)90359-9. [DOI] [PubMed] [Google Scholar]
  2. Biollaz J., Schelling J. L., Jacot Des Combes B., Brunner D. B., Desponds G., Brunner H. R., Ulm E. H., Hichens M., Gomez H. J. Enalapril maleate and a lysine analogue (MK-521) in normal volunteers; relationship between plasma drug levels and the renin angiotensin system. Br J Clin Pharmacol. 1982 Sep;14(3):363–368. doi: 10.1111/j.1365-2125.1982.tb01992.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Blythe W. B. Captopril and renal autoregulation. N Engl J Med. 1983 Feb 17;308(7):390–391. doi: 10.1056/NEJM198302173080709. [DOI] [PubMed] [Google Scholar]
  4. Creager M. A., Halperin J. L., Bernard D. B., Faxon D. P., Melidossian C. D., Gavras H., Ryan T. J. Acute regional circulatory and renal hemodynamic effects of converting-enzyme inhibition in patients with congestive heart failure. Circulation. 1981 Sep;64(3):483–489. doi: 10.1161/01.cir.64.3.483. [DOI] [PubMed] [Google Scholar]
  5. Dzau V. J., Colucci W. S., Hollenberg N. K., Williams G. H. Relation of the renin-angiotensin-aldosterone system to clinical state in congestive heart failure. Circulation. 1981 Mar;63(3):645–651. doi: 10.1161/01.cir.63.3.645. [DOI] [PubMed] [Google Scholar]
  6. Dzau V. J., Colucci W. S., Williams G. H., Curfman G., Meggs L., Hollenberg N. K. Sustained effectiveness of converting-enzyme inhibition in patients with severe congestive heart failure. N Engl J Med. 1980 Jun 19;302(25):1373–1379. doi: 10.1056/NEJM198006193022501. [DOI] [PubMed] [Google Scholar]
  7. Fitzpatrick D., Nicholls M. G., Ikram H., Espiner E. A. Haemodynamic, hormonal, and electrolyte effects of enalapril in heart failure. Br Heart J. 1983 Aug;50(2):163–169. doi: 10.1136/hrt.50.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hall J. E., Guyton A. C., Smith M. J., Jr, Coleman T. G. Chronic blockade of angiotensin II formation during sodium deprivation. Am J Physiol. 1979 Dec;237(6):F424–F432. doi: 10.1152/ajprenal.1979.237.6.F424. [DOI] [PubMed] [Google Scholar]
  9. Hricik D. E., Browning P. J., Kopelman R., Goorno W. E., Madias N. E., Dzau V. J. Captopril-induced functional renal insufficiency in patients with bilateral renal-artery stenoses or renal-artery stenosis in a solitary kidney. N Engl J Med. 1983 Feb 17;308(7):373–376. doi: 10.1056/NEJM198302173080706. [DOI] [PubMed] [Google Scholar]
  10. Moore T. J., Crantz F. R., Hollenberg N. K., Koletsky R. J., Leboff M. S., Swartz S. L., Levine L., Podolsky S., Dluhy R. G., Williams G. H. Contribution of prostaglandins to the antihypertensive action of captopril in essential hypertension. Hypertension. 1981 Mar-Apr;3(2):168–173. doi: 10.1161/01.hyp.3.2.168. [DOI] [PubMed] [Google Scholar]
  11. Mujais S. K., Fouad F. M., Textor S. C., Tarazi R. C., Bravo E. L., Hart N., Gifford R. W., Jr Transient renal dysfunction during initial inhibition of converting enzyme in congestive heart failure. Br Heart J. 1984 Jul;52(1):63–71. doi: 10.1136/hrt.52.1.63. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Murphy B. F., Whitworth J. A., Kincaid-Smith P. Renal insufficiency with combinations of angiotensin converting enzyme inhibitors and diuretics. Br Med J (Clin Res Ed) 1984 Mar 17;288(6420):844–845. doi: 10.1136/bmj.288.6420.844. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Pierpont G. L., Francis G. S., Cohn J. N. Effect of captopril on renal function in patients with congestive heart failure. Br Heart J. 1981 Nov;46(5):522–527. doi: 10.1136/hrt.46.5.522. [DOI] [PMC free article] [PubMed] [Google Scholar]

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