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. 1986 Aug;56(2):165–170. doi: 10.1136/hrt.56.2.165

Relation between alcohol intake, myocardial enzyme activity, and myocardial function in dilated cardiomyopathy. Evidence for the concept of alcohol induced heart muscle disease.

P J Richardson, A D Wodak, L Atkinson, J B Saunders, D E Jewitt
PMCID: PMC1236828  PMID: 3730217

Abstract

Detailed drinking histories were taken in 38 patients in whom dilated cardiomyopathy was diagnosed by cardiac catheterisation and left ventricular biopsy. On the basis of the drinking history twenty patients were classified as being in an abstinent or light drinking group and eighteen patients as being in a heavy drinking group (daily alcohol intake in excess of 80 g or cumulative lifetime intake exceeding 250 kg). Activities of myocardial creatine kinase, lactate dehydrogenase, alpha hydroxybutyric dehydrogenase, malic dehydrogenase, and aspartate amino-transferase were all higher in the heavy drinkers and myocardial enzyme activity correlated with cumulative lifetime alcohol intake, maximum daily intake, and recent daily intake. Activities of creatine kinase, alpha hydroxybutyric dehydrogenase, and malic dehydrogenase correlated with ejection fraction, irrespective of the alcohol intake of the patient. These findings were not altered by exclusion of patients with hypertension. The results indicate that among patients with dilated cardiomyopathy there is a group characterised by a high alcohol intake and raised myocardial tissue enzymes which supports the concept of alcoholic heart muscle disease as a distinct entity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRIGDEN W., ROBINSON J. ALCOHOLIC HEART DISEASE. Br Med J. 1964 Nov 21;2(5420):1283–1289. doi: 10.1136/bmj.2.5420.1283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cartwright A. K., Shaw S. J., Spratley T. A. The relationships between per capita consumption, drinking patterns and alcohol related problems in a population sample, 1965--1974. Part I: increased consumption and changes in drinking patterns. Br J Addict Alcohol Other Drugs. 1978 Sep;73(3):237–246. doi: 10.1111/j.1360-0443.1978.tb00150.x. [DOI] [PubMed] [Google Scholar]
  3. Fink R., Marjot D. H., Rosalki S. B. Detection of alcoholic cardiomyopathy by serum enzyme and isoenzyme determination. Ann Clin Biochem. 1979 May;16(3):165–166. doi: 10.1177/000456327901600135. [DOI] [PubMed] [Google Scholar]
  4. Goodwin J. F. Treatment of the cardiomyopathies. Am J Cardiol. 1973 Sep 7;32(3):341–351. doi: 10.1016/s0002-9149(73)80144-4. [DOI] [PubMed] [Google Scholar]
  5. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  6. MASSUMI R. A., RIOS J. C., GOOCH A. S., NUTTER D., DEVITA V. T., DATLOW D. W. PRIMARY MYOCARDIAL DISEASE: REPORT OF FIFTY CASES AND REVIEW OF THE SUBJECT. Circulation. 1965 Jan;31:19–41. doi: 10.1161/01.cir.31.1.19. [DOI] [PubMed] [Google Scholar]
  7. Morin Y. L., Foley A. R., Martineau G., Roussel J. Quebec beer-drinkers' cardiomyopathy: forty-eight cases. Can Med Assoc J. 1967 Oct 7;97(15):881–883. [PMC free article] [PubMed] [Google Scholar]
  8. Oakley C. Diagnosis and natural history of congested (dilated) cardiomyopathies. Postgrad Med J. 1978 Jul;54(633):440–450. doi: 10.1136/pgmj.54.633.440. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Olsen E. G. Pathological recognition of cardiomyopathy. Postgrad Med J. 1975 May;51(595):277–281. doi: 10.1136/pgmj.51.595.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Peters T. J., Wells G., Oakley C. M., Brooksby I. A., Jenkins B. S., Webb-Peploe M. M., Coltart D. J. Enzymic analysis of endomyocardial biopsy specimens from patients with cardiomyopathies. Br Heart J. 1977 Dec;39(12):1333–1339. doi: 10.1136/hrt.39.12.1333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Reichek N. Echocardiographic assessment of left ventricular hypertrophy. Eur Heart J. 1982 Apr;3 (Suppl A):49–57. doi: 10.1093/eurheartj/3.suppl_a.49. [DOI] [PubMed] [Google Scholar]
  12. Richardson P. J., Atkinson L., Wodak A. The measurement of enzyme activities in endomyocardial biopsies from patients with congestive (dilated) cardiomyopathy and specific heart muscle disease. Z Kardiol. 1982 Aug;71(8):522–526. [PubMed] [Google Scholar]
  13. Saunders J. B., Davis M., Williams R. Do women develop alcoholic liver disease more readily than men? Br Med J (Clin Res Ed) 1981 Apr 4;282(6270):1140–1143. doi: 10.1136/bmj.282.6270.1140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Saunders J. B., Wodak A. D., Haines A., Powell-Jackson P. R., Portmann B., Davis M., Williams R. Accelerated development of alcoholic cirrhosis in patients with HLA-B8. Lancet. 1982 Jun 19;1(8286):1381–1384. doi: 10.1016/s0140-6736(82)92500-4. [DOI] [PubMed] [Google Scholar]
  15. WENDT V. E., WU C., BALCON R., DOTY G., BING R. J. HEMODYNAMIC AND METABOLIC EFFECTS OF CHRONIC ALCOHOLISM IN MAN. Am J Cardiol. 1965 Feb;15:175–184. doi: 10.1016/0002-9149(65)90452-2. [DOI] [PubMed] [Google Scholar]

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