Abstract
In a heart with hypertrophic cardiomyopathy without asymmetrical septal hypertrophy the number of transmural myocytes, the mean size of myocytes, and the percentage area of interstitial space were similar in the ventricular septum and left ventricular posterior wall, whereas in a reported series of 14 hearts with hypertrophic cardiomyopathy with asymmetrical septal hypertrophy the number of transmural myocytes was greater in the ventricular septum than in the left ventricular posterior wall. In hearts with hypertrophic cardiomyopathy without asymmetrical septal hypertrophy the mean size of myocytes was significantly greater than that of normal hearts, but the number of transmural myocytes was not increased. The extent and distribution pattern of myocardial fibre disarray and fibrosis in the left ventricle were similar in hearts with hypertrophic myopathy whether or not asymmetrical septal hypertrophy was present.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Asymmetric septal hypertrophy. Ann Intern Med. 1974 Nov;81(5):650–680. doi: 10.7326/0003-4819-81-5-650. [DOI] [PubMed] [Google Scholar]
- Fujiwara H., Hoshino T., Fujiwara T., Kawai C., Hamashima Y. Classification and distribution of myocardial fascicle and fiber disarray in 14 hearts with hypertrophic cardiomyopathy in 25 mu thick sections. Jpn Circ J. 1982 Mar;46(3):225–234. doi: 10.1253/jcj.46.225. [DOI] [PubMed] [Google Scholar]
- Fujiwara H., Hoshino T., Yamana K., Fujiwara T., Furuta M., Hamashima Y., Kawai C. Number and size of myocytes and amount of interstitial space in the ventricular septum and in the left ventricular free wall in hypertrophic cardiomyopathy. Am J Cardiol. 1983 Oct 1;52(7):818–823. doi: 10.1016/0002-9149(83)90421-6. [DOI] [PubMed] [Google Scholar]
- Fujiwara H., Kawai C., Hamashima Y. Myocardial fascicle and fiber disarray in 25 mu-thick sections. Circulation. 1979 Jun;59(6):1293–1298. doi: 10.1161/01.cir.59.6.1293. [DOI] [PubMed] [Google Scholar]
- Fujiwara H., Onodera T., Tanaka M., Shirane H., Kato H., Yoshikawa J., Osakada G., Sasayama S., Kawai C. Progression from hypertrophic obstructive cardiomyopathy to typical dilated cardiomyopathy-like features in the end stage. Jpn Circ J. 1984 Nov;48(11):1210–1214. doi: 10.1253/jcj.48.1210. [DOI] [PubMed] [Google Scholar]
- Henry W. L., Clark C. E., Epstein S. E. Asymmetric septal hypertrophy. Echocardiographic identification of the pathognomonic anatomic abnormality of IHSS. Circulation. 1973 Feb;47(2):225–233. doi: 10.1161/01.cir.47.2.225. [DOI] [PubMed] [Google Scholar]
- Maron B. J., Epstein S. E. Hypertrophic cardiomyopathy. Recent observations regarding the specificity of three hallmarks of the disease: asymmetric septal hypertrophy, septal disorganization and systolic anterior motion of the anterior mitral leaflet. Am J Cardiol. 1980 Jan;45(1):141–154. doi: 10.1016/0002-9149(80)90232-5. [DOI] [PubMed] [Google Scholar]
- Maron B. J., Epstein S. E., Roberts W. C. Hypertrophic cardiomyopathy and transmural myocardial infarction without significant atherosclerosis of the extramural coronary arteries. Am J Cardiol. 1979 Jun;43(6):1086–1102. doi: 10.1016/0002-9149(79)90139-5. [DOI] [PubMed] [Google Scholar]
- Shapiro L. M., McKenna W. J. Distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy: a two-dimensional echocardiographic study. J Am Coll Cardiol. 1983 Sep;2(3):437–444. doi: 10.1016/s0735-1097(83)80269-1. [DOI] [PubMed] [Google Scholar]
- TEARE D. Asymmetrical hypertrophy of the heart in young adults. Br Heart J. 1958 Jan;20(1):1–8. doi: 10.1136/hrt.20.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tanaka M., Fujiwara H., Onodera T., Wu D. J., Hamashima Y., Kawai C. Quantitative analysis of myocardial fibrosis in normals, hypertensive hearts, and hypertrophic cardiomyopathy. Br Heart J. 1986 Jun;55(6):575–581. doi: 10.1136/hrt.55.6.575. [DOI] [PMC free article] [PubMed] [Google Scholar]