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. 1976 Jul;125(1):47–55.

Mycoplasma Pneumoniae Infections of Adults and Children

James D Cherry 1, Robert C Welliver 1
PMCID: PMC1237178  PMID: 782043

Abstract

Although the hallmark of Mycoplasma pneumoniae infection is pneumonia, the organism is also responsible for a protean array of other symptoms. With an increased awareness of the board clinical spectrum of M. pneumoniae disease and the ready availability of the cold agglutinin and M. pneumoniae complement-fixation tests, interested clinicians will note additional clinical-mycoplasmal associations in their patients.

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Selected References

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  1. BALL J. S. PIGMENTATION OF THE PRIMARY DENTITION: PATHOGENESIS AND DIAGNOSTIC IMPLICATIONS. Clin Pediatr (Phila) 1964 Jul;3:394–404. doi: 10.1177/000992286400300704. [DOI] [PubMed] [Google Scholar]
  2. Balassanian N., Robbins F. C. Mycoplasma pneumoniae infection in families. N Engl J Med. 1967 Oct 5;277(14):719–725. doi: 10.1056/NEJM196710052771401. [DOI] [PubMed] [Google Scholar]
  3. Benisch B. M., Fayemi A., Gerber M. A., Axelrod J. Mycoplasmal pneumonia in a patient with rheumatic heart disease. Am J Clin Pathol. 1972 Sep;58(3):343–348. doi: 10.1093/ajcp/58.3.343. [DOI] [PubMed] [Google Scholar]
  4. Biberfeld G. Antibodies to brain and other tissues in cases of Mycoplasma pneumoniae infection. Clin Exp Immunol. 1971 Feb;8(2):319–333. [PMC free article] [PubMed] [Google Scholar]
  5. Biberfeld G., Sterner G. A study of Mycoplasma pneumoniae infections in families. Scand J Infect Dis. 1969 May;1(1):39–46. doi: 10.3109/inf.1969.1.issue-1.06. [DOI] [PubMed] [Google Scholar]
  6. CHANOCK R. M., RIFKIND D., KRAVETZ H. M., KINGHT V., JOHNSON K. M. Respiratory disease in volunteers infected with Eaton agent: a preliminary report. Proc Natl Acad Sci U S A. 1961 Jun 15;47:887–890. doi: 10.1073/pnas.47.6.887. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Chanock R. M. Mycoplasma infections of man. N Engl J Med. 1965 Nov 25;273(22):1199–contd. doi: 10.1056/NEJM196511252732206. [DOI] [PubMed] [Google Scholar]
  8. Cherry J. D., Allen V. D., Sueltmann S. Search for Mycoplasma pneumoniae infection in patients with exanthem but without pneumonia. Arch Environ Health. 1968 Jun;16(6):911–912. doi: 10.1080/00039896.1968.10665174. [DOI] [PubMed] [Google Scholar]
  9. Cherry J. D., Hurwitz E. S., Welliver R. C. Mycoplasma pneumoniae infections and exanthems. J Pediatr. 1975 Sep;87(3):369–373. doi: 10.1016/s0022-3476(75)80637-8. [DOI] [PubMed] [Google Scholar]
  10. Cherry J. D. Newer respiratory viruses: their role in respiratory illness of children. Adv Pediatr. 1973;20:225–290. [PubMed] [Google Scholar]
  11. Cherry J. D. Newer viral exanthems. Adv Pediatr. 1969;16:233–286. [PubMed] [Google Scholar]
  12. Cherry J. D., Taylor-Robinson D. Peroxide production by mycoplasmas in chicken tracheal organ cultures. Nature. 1970 Dec 12;228(5276):1099–1100. doi: 10.1038/2281099a0. [DOI] [PubMed] [Google Scholar]
  13. Clyde W. A., Jr, Denny F. W. Mycoplasma infections in childhood. Pediatrics. 1967 Oct;40(4):669–684. [PubMed] [Google Scholar]
  14. Copps S. C., Allen V. D., Sueltmann S., Evans A. S. A community outbreak of Mycoplasma pneumonia. JAMA. 1968 Apr 8;204(2):123–128. [PubMed] [Google Scholar]
  15. Denny F. W., Clyde W. A., Jr, Glezen W. P. Mycoplasma pneumoniae disease: clinical spectrum, pathophysiology, epidemiology, and control. J Infect Dis. 1971 Jan;123(1):74–92. doi: 10.1093/infdis/123.1.74. [DOI] [PubMed] [Google Scholar]
  16. Evatt B. L., Dowdle W. R., Johnson M., Jr, Heath C. W., Jr Epidemic mycoplasma pneumonia. N Engl J Med. 1971 Aug 12;285(7):374–378. doi: 10.1056/NEJM197108122850704. [DOI] [PubMed] [Google Scholar]
  17. Feizi O., Grubb C., Skinner J. I., Constantinidou M., Henderson W. G. Primary atypical pneumonia due to Mycoplasma pneumoniae complicated by haemorrhagic pleural effusion, haemolytic anaemia and myocarditis. Br J Clin Pract. 1973 Mar;27(3):99–101. [PubMed] [Google Scholar]
  18. Feizi T. Cold agglutinins, the direct coombs' test and serum immunoglobulins in Mycoplasma pneumoniae infection. Ann N Y Acad Sci. 1967 Jul 28;143(1):801–812. doi: 10.1111/j.1749-6632.1967.tb27728.x. [DOI] [PubMed] [Google Scholar]
  19. Feizi T., Maclean H., Sommerville R. G., Selwyn J. G. Studies on an epidemic of respiratory disease caused by Mycoplasma pneumoniae. Br Med J. 1967 Feb 25;1(5538):457–460. doi: 10.1136/bmj.1.5538.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Fiala M., Myhre B. A., Chinh L. T., Territo M., Edgington T. S., Kattlove H. Pathogenesis of anemia associated with Mycoplasma pneumoniae. Acta Haematol. 1974;51(5):297–301. doi: 10.1159/000208309. [DOI] [PubMed] [Google Scholar]
  21. Fine N. L., Smith L. R., Sheedy P. F. Frequency of pleural effusions in mycoplasma and viral pneumonias. N Engl J Med. 1970 Oct 8;283(15):790–793. doi: 10.1056/NEJM197010082831505. [DOI] [PubMed] [Google Scholar]
  22. Foy H. M., Cooney M. K., McMahan R., Grayston J. T. Viral and mycoplasmal pneumonia in a prepaid medical care group during an eight-year period. Am J Epidemiol. 1973 Feb;97(2):93–102. doi: 10.1093/oxfordjournals.aje.a121493. [DOI] [PubMed] [Google Scholar]
  23. Foy H. M., Grayston J. T., Kenny G. E., Alexander E. R., McMahan R. Epidemiology of Mycoplasma pneumoniae infection in families. JAMA. 1966 Sep 12;197(11):859–866. [PubMed] [Google Scholar]
  24. Foy H. M., Kenny G. E., McMahan R., Kaiser G., Grayston J. T. Mycoplasma pneumoniae in the community. Am J Epidemiol. 1971 Jan;93(1):55–67. doi: 10.1093/oxfordjournals.aje.a121228. [DOI] [PubMed] [Google Scholar]
  25. Foy H. M., Kenny G. E., McMahan R., Mansy A. M., Grayston J. T. Mycoplasma pneumoniae pneumonia in an urban area. Five years of surveillance. JAMA. 1970 Nov 30;214(9):1666–1672. [PubMed] [Google Scholar]
  26. Foy H. M., Ochs H., Davis S. D., Kenny G. E., Luce R. R. Mycoplasma pneumoniae infections in patients with immunodeficiency syndromes: report of four cases. J Infect Dis. 1973 Apr;127(4):388–393. doi: 10.1093/infdis/127.4.388. [DOI] [PubMed] [Google Scholar]
  27. Fransén H., Forsgren M., Heigl Z., Tunevall G. Studies on Mycoplasma pneumoniae in patients hospitalized with acute respiratory illness. Scand J Infect Dis. 1969;1(2):91–98. doi: 10.3109/inf.1969.1.issue-2.04. [DOI] [PubMed] [Google Scholar]
  28. Freundt E. A. Present status of the medical importance of mycoplasmas. Pathol Microbiol (Basel) 1974;40(3):155–187. doi: 10.1159/000162521. [DOI] [PubMed] [Google Scholar]
  29. GRAYSTON J. T., ALEXANDER E. R., KENNY G. E., CLARKE E. R., FREMONT J. C., MACCOLL W. A. MYCOPLASMA PNEUMONIAE INFECTIONS. CLINICAL AND EPIDEMIOLOGIC STUDIES. JAMA. 1965 Feb 1;191:369–374. doi: 10.1001/jama.1965.03080050015004. [DOI] [PubMed] [Google Scholar]
  30. GRIFFIN J. P., CRAWFORD Y. E. MYCOPLASMA PNEUMONIAE IN PRIMARY ATYPICAL PNEUMONIA. JAMA. 1965 Sep 20;193:1011–1016. doi: 10.1001/jama.1965.03090120019005. [DOI] [PubMed] [Google Scholar]
  31. George R. B., Weill H., Rasch J. R., Mogabgab W. J., Ziskind M. M. Roentgenographic appearance of viral and mycoplasmal pneumonias. Am Rev Respir Dis. 1967 Dec;96(6):1144–1150. doi: 10.1164/arrd.1967.96.6.1144. [DOI] [PubMed] [Google Scholar]
  32. George R. B., Ziskind M. M., Rasch J. R., Mogabgab W. J. Mycoplasma and adenovirus pneumonias. Comparison with other atypical pneumonias in a military population. Ann Intern Med. 1966 Nov;65(5):931–942. doi: 10.7326/0003-4819-65-5-931. [DOI] [PubMed] [Google Scholar]
  33. Glezen P., Denny F. W. Epidemiology of acute lower respiratory disease in children. N Engl J Med. 1973 Mar 8;288(10):498–505. doi: 10.1056/NEJM197303082881005. [DOI] [PubMed] [Google Scholar]
  34. Glezen W. P., Clyde W. A., Jr, Senior R. J., Sheaffer C. I., Denny F. W. Group A streptococci, mycoplasmas, and viruses associated with acute pharyngitis. JAMA. 1967 Nov 6;202(6):455–460. [PubMed] [Google Scholar]
  35. Greenberg H., Helms C. M., Brunner H., Chanock R. M. Asymptomatic infection of adult volunteers with a temperature sensitive mutant of Mycoplasma pneumoniae. Proc Natl Acad Sci U S A. 1974 Oct;71(10):4015–4019. doi: 10.1073/pnas.71.10.4015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Griffin J. P. Rapid screening for cold agglutinins in pneumonia. Ann Intern Med. 1969 Apr;70(4):701–705. doi: 10.7326/0003-4819-70-4-701. [DOI] [PubMed] [Google Scholar]
  37. Grix A., Giammona S. T. Pneumonitis with pleural effusion in children due to Mycoplasma pneumoniae. Am Rev Respir Dis. 1974 Jun;109(6):665–671. doi: 10.1164/arrd.1974.109.6.665. [DOI] [PubMed] [Google Scholar]
  38. Halsted C., Lepow M. L., Balassanian N., Emmerich J., Wolinsky E. Otitis media. Clinical observations, microbiology, and evaluation of therapy. Am J Dis Child. 1968 May;115(5):542–551. doi: 10.1001/archpedi.1968.02100010544003. [DOI] [PubMed] [Google Scholar]
  39. Hers J. F. Clinical aspects of infection with Mycoplasma pneumoniae. Proc R Soc Med. 1968 Dec 12;61(12):1325–1330. doi: 10.1177/003591576806101242. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Hodges G. R., Fass R. J., Saslaw S. Central nervous system disease associated with Mycoplasma pneumoniae infection. Arch Intern Med. 1972 Aug;130(2):277–282. [PubMed] [Google Scholar]
  41. Jansson E., von Essen R., Tuuri S. Mycoplasma pneumoniae pneumonia in Helsinki 1962-1970. Epidemic pattern and autoimmune manifestations. Scand J Infect Dis. 1971;3(1):51–54. doi: 10.3109/inf.1971.3.issue-1.09. [DOI] [PubMed] [Google Scholar]
  42. Jensen K. J., Senterfit L. B., Scully W. E., Conway T. J., West R. F., Drummy W. W. Mycoplasma pneumoniae infections in children. An epidemiologic appraisal in families treated with oxytetracycline. Am J Epidemiol. 1967 Sep;86(2):419–432. doi: 10.1093/oxfordjournals.aje.a120752. [DOI] [PubMed] [Google Scholar]
  43. Jones G. R., Stewart S. M. A prospective study of the persistence of Mycoplasma pneumoniae antibody levels. Scott Med J. 1974 May;19(3):129–133. doi: 10.1177/003693307401900306. [DOI] [PubMed] [Google Scholar]
  44. Jones M. C. Aethritis and arthralgia in infection with Mycoplasma pneumoniae. Thorax. 1970 Nov;25(6):748–750. doi: 10.1136/thx.25.6.748. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. KINGSTON J. R., CHANOCK R. M., MUFSON M. A., HELLMAN L. P., JAMES W. D., FOX H. H., MANKO M. A., BOYERS J. Eaton agent pneumonia. JAMA. 1961 Apr 15;176:118–123. doi: 10.1001/jama.1961.03040150034009. [DOI] [PubMed] [Google Scholar]
  46. Lambert H. P. Infections caused by Mycoplasma pneumoniae. Br J Dis Chest. 1969 Apr;63(2):71–82. doi: 10.1016/s0007-0971(69)80032-x. [DOI] [PubMed] [Google Scholar]
  47. Lambert H. P. Syndrome with joint manifestations in association with Mycoplasma pneumoniae infection. Br Med J. 1968 Jul 20;3(5611):156–157. doi: 10.1136/bmj.3.5611.156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Leinikki P., Pantzar P. Acute pancreatitis in mycoplasma pneumoniae infections. Br Med J. 1973 Jun 2;2(5865):554–554. doi: 10.1136/bmj.2.5865.554-c. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Lerer R. J., Kalavsky S. M. Central nervous system disease associated with Mycoplasma pneumoniae infection: report of five cases and review of the literature. Pediatrics. 1973 Nov;52(5):658–668. [PubMed] [Google Scholar]
  50. Lewis J. E., Sheptin C. Mycoplasmal pneumonia associated with abscess of the lung. Calif Med. 1972 Dec;117(6):69–72. [PMC free article] [PubMed] [Google Scholar]
  51. Lyell A., Gordon A. M., Dick H. M., Sommerville R. G. Mycoplasmas and erythema multiforme. Lancet. 1967 Nov 25;2(7526):1116–1118. doi: 10.1016/s0140-6736(67)90620-4. [DOI] [PubMed] [Google Scholar]
  52. MARMION B. P., GOODBURN G. M. Effect of an organic gold salt on Eaton's primary atypical pneumonia agent and other observations. Nature. 1961 Jan 21;189:247–248. doi: 10.1038/189247a0. [DOI] [PubMed] [Google Scholar]
  53. Maisel J. C., Babbitt L. H., John T. J. Fatal Mycoplasma pneumoniae infection with isolation of organisms from lung. JAMA. 1967 Oct 23;202(4):287–290. [PubMed] [Google Scholar]
  54. McCormick D. P., Wenzel R. P., Senterfit L. B., Beam W. E., Jr Relationship of pre-existing antibody to subsequent infection by Mycoplasma pneumoniae in adults. Infect Immun. 1974 Jan;9(1):53–59. doi: 10.1128/iai.9.1.53-59.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. McNamara M. J., Phillips I. A., Williams O. B. Viral and Mycoplasma pneumoniae infections in exacerbations of chronic lung disease. Am Rev Respir Dis. 1969 Jul;100(1):19–24. doi: 10.1164/arrd.1969.100.1.19. [DOI] [PubMed] [Google Scholar]
  56. Meyers B. R., Hirschman S. Z. Fatal infections associated with Mycoplasma pneumoniae: discussion of three cases with necropsy findings. Mt Sinai J Med. 1972 May-Jun;39(3):258–264. [PubMed] [Google Scholar]
  57. Mogabgab W. J. Protective effects of inactive Mycoplasma pneumoniae vaccine in military personnel, 1964-1966. Am Rev Respir Dis. 1968 Mar;97(3):359–365. doi: 10.1164/arrd.1968.97.3.359. [DOI] [PubMed] [Google Scholar]
  58. Mårdh P. A., Ursing B. The occurrence of acute pancreatitis in Mycoplasma pneumoniae infection. Scand J Infect Dis. 1974;6(2):167–171. doi: 10.3109/inf.1974.6.issue-2.11. [DOI] [PubMed] [Google Scholar]
  59. Naftalin J. M., Wellisch G., Kahana Z., Diengott D. Letter: Mycoplasma pneumoniae septicemia. JAMA. 1974 Apr 29;228(5):565–565. doi: 10.1001/jama.228.5.565d. [DOI] [PubMed] [Google Scholar]
  60. Naraqi S., Kabins S. A. Mycoplasma pneumoniae monoarticular arthritis. J Pediatr. 1973 Oct;83(4):621–623. doi: 10.1016/s0022-3476(73)80224-0. [DOI] [PubMed] [Google Scholar]
  61. RIFKIND D., CHANOCK R., KRAVETZ H., JOHNSON K., KNIGHT V. Ear involvement (myringitis) and primary atypical pneumonia following inoculation of volunteers with Eaton agent. Am Rev Respir Dis. 1962 Apr;85:479–489. doi: 10.1164/arrd.1962.85.4.479. [DOI] [PubMed] [Google Scholar]
  62. Roberts-Thomson I. C., Cottew G. S., Fraser J. R. Mycoplasma pneumonia with severe haemolytic anaemia. Med J Aust. 1973 Dec 8;2(23):1046–1047. doi: 10.5694/j.1326-5377.1973.tb129945.x. [DOI] [PubMed] [Google Scholar]
  63. SOBESLAVSKY O., ABRAHAMOVIC M. THE ETIOLOGICAL ROLE OF MYCOPLASMA PNEUMONIAE IN OTITIS MEDIA IN CHILDREN. Pediatrics. 1965 Apr;35:652–657. [PubMed] [Google Scholar]
  64. Shames J. M., George R. B., Holliday W. B., Rasch J. R., Mogabgab W. J. Comparison of antibiotics in the treatment of mycoplasmal pneumonia. Arch Intern Med. 1970 Apr;125(4):680–684. [PubMed] [Google Scholar]
  65. Shulman S. T., Bartlett J., Clyde W. A., Jr, Ayoub E. M. The unusual severity of Mycoplasmal pneumonia in children with sickle-cell disease. N Engl J Med. 1972 Jul 27;287(4):164–167. doi: 10.1056/NEJM197207272870403. [DOI] [PubMed] [Google Scholar]
  66. Siegler D. I. Lung abscess associated with Mycoplasma pneumoniae infection. Br J Dis Chest. 1973 Apr;67(2):123–127. doi: 10.1016/0007-0971(73)90041-7. [DOI] [PubMed] [Google Scholar]
  67. Smith C. B., Friedewald W. T., Chanock R. M. Inactivated Mycoplasma pneumoniae vaccine. Evaluation in volunteers. JAMA. 1967 Feb 6;199(6):353–358. [PubMed] [Google Scholar]
  68. Sprinkle P. M. Current status of mycoplasmatales and bacterial variants in chronic otolaryngic disease. Laryngoscope. 1972 Apr;82(4):737–747. doi: 10.1288/00005537-197204000-00018. [DOI] [PubMed] [Google Scholar]
  69. Steinberg P., White R. J., Fuld S. L., Gutekunst R. R., Chanock R. M., Senterfit L. B. Ecology of Mycoplasma pneumoniae infections in marine recruits at Parris Island, South Carolina. Am J Epidemiol. 1969 Jan;89(1):62–73. doi: 10.1093/oxfordjournals.aje.a120916. [DOI] [PubMed] [Google Scholar]
  70. Sussman S. J., Magoffin R. L., Lennette E. H., Schieble J. Cold agglutinins, Eaton agent, and respiratory infections of children. Pediatrics. 1966 Oct;38(4):571–577. [PubMed] [Google Scholar]
  71. Turner J. A., Burchak E. C., Bannatyne R. M., Fleming P. C. The protean manifestattions of mycoplasma infections in childhood. Can Med Assoc J. 1968 Oct 5;99(13):633–637. [PMC free article] [PubMed] [Google Scholar]
  72. Weinstein M. P., Hall C. B. Mycoplasma pneumoniae infection associated with migratory polyarthritis. Am J Dis Child. 1974 Jan;127(1):125–126. doi: 10.1001/archpedi.1974.02110200127020. [DOI] [PubMed] [Google Scholar]
  73. Westerberg S. C., Smith C. B., Renzetti A. D. Mycoplasma infections in patients with chronic obstructive pulmonary disease. J Infect Dis. 1973 May;127(5):491–497. doi: 10.1093/infdis/127.5.491. [DOI] [PubMed] [Google Scholar]

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