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. 1977 Jan;126(1):5–13.

Intravenous and Intrathecal Miconazole Therapy for Systemic Mycoses

James P Sung 1,2, Jan G Grendahl 1,2, H B Levine 1,2
PMCID: PMC1237424  PMID: 576177

Abstract

Ten patients with systemic mycoses, including five with fungal meningitis, were treated with intravenously or intrathecally administered miconazole, or both. Minimal inhibitory concentrations of miconazole for clinical isolates of Coccidioides immitis, Cryptococcus neoformans and Candida albicans were less than 0.6 µg per ml. Except for pruritis of variable degrees, the drug was well tolerated both intravenously and intrathecally by all patients. No measurable impairment of renal, hepatic or bone marrow function was observed in patients after 4½ months of intravenous therapy. No hematological or biochemical abnormalities and no evidence of recurrent coccidioidal osteomyelitis were observed in 16 months of follow-up in our first patient treated with this drug. Miconazole is apparently an effective antifungal drug of low toxicity and is a potentially useful agent for treatment of human systemic mycoses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Daneels R., Demeyere R., Eggers L., Lust P., van Landuyt H., Symoens J. Zur Behandlung systemischer Candidiasis mit Miconazol. Med Welt. 1974 Mar 8;25(10):428–429. [PubMed] [Google Scholar]
  2. De Nollin S., Borgers M. Scanning electron microscopy of Candida albicans after in vitro treatment with miconazole. Antimicrob Agents Chemother. 1975 May;7(5):704–711. doi: 10.1128/aac.7.5.704. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. De Nollin S., Borgers M. The ultrastructure of Candida albicans after in vitro treatment with miconazole. Sabouraudia. 1974 Nov;12(3):341–351. [PubMed] [Google Scholar]
  4. Godefroi E. F., Heeres J., Van Cutsem J., Janssen P. A. The preparation and antimycotic properties of derivatives of 1-phenethylimidazole. J Med Chem. 1969 Sep;12(5):784–791. doi: 10.1021/jm00305a014. [DOI] [PubMed] [Google Scholar]
  5. Hart P. D., Russell E., Jr, Remington J. S. The compromised host and infection. II. Deep fungal infection. J Infect Dis. 1969 Aug;120(2):169–191. doi: 10.1093/infdis/120.2.169. [DOI] [PubMed] [Google Scholar]
  6. Hoeprich P. D., Goldstein E. Miconazole therapy for coccidioidomycosis. JAMA. 1974 Nov 25;230(8):1153–1157. [PubMed] [Google Scholar]
  7. Levine H. B., Stevens D. A., Cobb J. M., Gebhardt A. E. Miconazole in coccidioidomycosis. I. Assays of activity in mice and in vitro. J Infect Dis. 1975 Oct;132(4):407–414. doi: 10.1093/infdis/132.4.407. [DOI] [PubMed] [Google Scholar]
  8. McLaurin R. L. Infected cerebrospinal fluid shunts. Surg Neurol. 1973 Jul;1(4):191–195. [PubMed] [Google Scholar]
  9. Rifkind D., Marchioro T. L., Schneck S. A., Hill R. B., Jr Systemic fungal infections complicating renal transplantation and immunosuppressive therapy. Clinical, microbiologic, neurologic and pathologic features. Am J Med. 1967 Jul;43(1):28–38. doi: 10.1016/0002-9343(67)90146-5. [DOI] [PubMed] [Google Scholar]
  10. Scheef W., Symoens J., Van Camp K., Daneels R., De Leeuw-Delvigne C. Letter: Chemotherapy of candidiasis. Br Med J. 1974 Jan 12;1(5897):78–78. doi: 10.1136/bmj.1.5897.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sreedhara Swamy K. H., Sirsi M., Ramananda Rao G. R. Studies on the mechanism of action of miconazole: effect of miconazole on respiration and cell permeability of Candida albicans. Antimicrob Agents Chemother. 1974 Apr;5(4):420–425. doi: 10.1128/aac.5.4.420. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Stevens D. A., Levine H. B., Deresinski S. C. Miconazole in coccidiodomycosis. II. Therapeutic and pharmacologic studies in man. Am J Med. 1976 Feb;60(2):191–202. doi: 10.1016/0002-9343(76)90428-9. [DOI] [PubMed] [Google Scholar]
  13. Sung J. P. Treatment of disseminated coccidioidomycosis with miconazole. West J Med. 1976 Jan;124(1):61–64. [PMC free article] [PubMed] [Google Scholar]
  14. Van Cutsem J. M., Thienpont D. Miconazole, a broad-spectrum antimycotic agent with antibacterial activity. Chemotherapy. 1972;17(6):392–404. doi: 10.1159/000220875. [DOI] [PubMed] [Google Scholar]
  15. WINN W. A. THE TREATMENT OF COCCIDIOIDAL MENINGITIS. THE USE OF AMPHOTERICIN B IN A GROUP OF 25 PATIENTS. Calif Med. 1964 Aug;101:78–89. [PMC free article] [PubMed] [Google Scholar]
  16. Zazgornik J., Schmidt P., Kopsa H., Kotzaurek R. Erfolgreiche Behandlung einer Candida-albicans-sepsis nach Nierentransplantation. Dtsch Med Wochenschr. 1973 Jan 5;98(1):15–17. doi: 10.1055/s-0028-1106737. [DOI] [PubMed] [Google Scholar]

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