Table 1.
Summary of modes of neutrophil death in response to stimulation
| Simulation/mode of death | Apoptosis | Pyroptosis | Necroptosis | Ferroptosis | NETosis |
|---|---|---|---|---|---|
| Adhesion | Focal adhesion kinase engagement 39 | ||||
| Type 1-fimbriated Escherichia coli | Cathepsin mediated Bid cleavage41 | ||||
| Phagocytosis of pathogens | ROS dependent upregulation of proapoptotic proteins42,48 | ||||
| Protease proteinase 3 | Caspase-9 activation43 | Caspase-3 activation cleaves GSDME62 | |||
| Cytochrome c/ Apaf-1 | Apoptotic Caspase activation46,47 | ||||
| Fas ligand | Fas162,163 | ||||
| TNF-related apoptosis-inducing ligand | TRAIL-R2 and R3 receptors163,164 | ||||
| TNF-a (high doses) | mitoROS production165,166 | RIPK3 (when apoptosis was blocked)74 | |||
| Lipopolysaccharide (LPS)+ Nigericin | GSDMD localization to primary granlues60 | Cytosolic LPS-GSDMD167 | |||
| Pseudomonas aeruginosa | NLRC4/NLRP3-GSDMD168,169 | ||||
| Burkholderia thailandensis | NLRC4-GSDMD170 | ||||
| Leishmania mexicana | NLRP1-GSDMD171 | ||||
| Aspergillus fumigatus | NLRP3- GSDM-D172 | ||||
| Cell adhesion molecule ligation | ROS-RIPK373 | ||||
| Birinapant+z-VAD-fmk | RIPK3 (when apoptosis was blocked)79 | ||||
| SLE IgG/ IFN-α | Gpx4 down-regulation85 | ||||
| RSL3 | Gpx4 inhibition 86 | ||||
| PMA | PKC activation88,101 | ||||
| Ionomycin | Calcium influx-PAD4 activation101,173 | ||||
| Various Bacteria | ROS-PKC (PAD4?) activation90,101,174 | ||||
| Candida albicans | β-glucan, PKC acivation89,96,101 | ||||
| Platelets | Neutrophil-platelet aggregation98 | ||||
| IgG Immune complex | Fc receptor signlaing175,176 |