Corrigendum to “Inhibition of Mitofusin-2 Promotes Cardiac Fibroblast Activation via the PERK/ATF4 Pathway and Reactive Oxygen Species”

Y. Xin, W. Wu, J. Qu, et al., “Inhibition of Mitofusin-2 Promotes Cardiac Fibroblast Activation via the PERK/ATF4 Pathway and Reactive Oxygen Species”, Oxidative Medicine and Cellular Longevity 2019 (2019): 3649808, https://doi.org/10.1155/2019/3649808.

In the article, an image duplication was identified in Figure 1a with the Control and TGF-β1 of Xbp1s [1].

Figure 1.

Mfn2 modulated ER stress through repression of the PERK/ATF4 pathway in activated cardiac fibroblasts. (a) Protein expressions of p-PERK, ATF4, p-IRE1α, Xbp1s, and c-ATF6 with TGF-β1 treatment in cardiac fibroblasts (n = 3); (b) protein expressions of p-PERK, ATF4, p-IRE1α, Xbp1s, and c-ATF6 in cardiac fibroblasts with siMfn2 transfection in the presence or absence of TGF-β1 (n = 3); (c) protein expressions of p-PERK, ATF4, p-IRE1α, Xbp1s, and c-ATF6 in cardiac fibroblasts with overexpression adenovirus transduction in the presence or absence of TGF-β1 (n = 3); (d) the protein level of the ER stress branch, the PERK/ATF4 pathway, after siMfn2 transfection (n = 3); siMfn2 transfection in the presence or absence of 4-PBA; (e) the protein levels of α-SMA, TGF-β, and CTGF in cardiac fibroblasts after transfection with siMfn2 (n = 3); siMfn2 transfection in the presence or absence of 4-PBA; (f) the proliferation rate of cardiac fibroblasts (the red fluorescence indicated EdU-incorporated cells and the blue fluorescence indicated the cell nucleus stained by DAPI, n = 120) after transfection with siMfn2; siMfn2 transfection in the presence or absence of 4-PBA; (g) the protein level of the ER stress branch, the PERK/ATF4 pathway, after overexpression adenovirus transduction (n = 3); adenovirus transduction in the presence or absence of thapsigargin; (h) the protein levels of α-SMA, TGF-β, and CTGF in cardiac fibroblasts after transduction with overexpression adenovirus (n = 3); overexpression adenovirus transduction in the presence or absence of thapsigargin; (i) the proliferation rate of cardiac fibroblasts (the red fluorescence indicated EdU-incorporated cells and the blue fluorescence indicated the cell nucleus stained by DAPI, n = 120) after transduction with adenovirus; overexpression adenovirus transduction in the presence or absence of thapsigargin; (j) protein expression of ATF4 with siMfn2 transfection followed with siATF4 transfection in the presence or absence of TGF-β1 in cardiac fibroblasts; (k) the protein levels of α-SMA, TGF-β, and CTGF in cardiac fibroblasts after siMfn2 transfection followed with siATF4 transfection in the presence or absence of TGF-β1 in cardiac fibroblasts; data in (a–k) are expressed as mean ± SEM. ⁣_∗ indicates p < 0.05,  _∗∗ indicates p < 0.01, and  _∗∗⁣_∗ indicates p < 0.001 vs. the NC or siMfn2 groups.

The authors explained that this was due to an error during the preparation of the manuscript and provided the correct image. The corrected Figure 1a is shown below:

The authors and the Editorial board agree to the publication of the corrigendum.

We apologize for this error.