Abstract
All of the changes observed suggest that a viral agent may form the basis for these alterations [in rheumatoid synovium]. However, studies to date have failed to isolate or identify the putative causative virus and the search continues.
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Selected References
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- Dayer J. M., Graham R., Russell G., Krane S. M. Collagenase production by rheumatoid synovial cells: stimulation by a human lymphocyte factor. Science. 1977 Jan 14;195(4274):181–183. doi: 10.1126/science.188134. [DOI] [PubMed] [Google Scholar]
- Dayer J. M., Krane S. M., Russell R. G., Robinson D. R. Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells. Proc Natl Acad Sci U S A. 1976 Mar;73(3):945–949. doi: 10.1073/pnas.73.3.945. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harris E. D., Jr, Glauert A. M., Murley A. H. Intracellular collagen fibers at the pannus-cartilage junction in rheumatoid arthritis. Arthritis Rheum. 1977 Mar;20(2):657–665. doi: 10.1002/art.1780200204. [DOI] [PubMed] [Google Scholar]
- Kobayashi I., Ziff M. Electron microscopic studies of the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum. 1975 Sep-Oct;18(5):475–483. doi: 10.1002/art.1780180507. [DOI] [PubMed] [Google Scholar]
- Kuettner K. E., Soble L., Croxen R. L., Marczynska B., Hiti J., Harper E. Tumor cell collagenase and its inhibition by a cartilage-derived protease inhibitor. Science. 1977 May 6;196(4290):653–654. doi: 10.1126/science.193181. [DOI] [PubMed] [Google Scholar]
- Langer R., Brem H., Falterman K., Klein M., Folkman J. Isolations of a cartilage factor that inhibits tumor neovascularization. Science. 1976 Jul 2;193(4247):70–72. doi: 10.1126/science.935859. [DOI] [PubMed] [Google Scholar]
- Newcombe D. S., Ciosek C. P., Jr, Ishikawa Y., Fahey J. V. Human synoviocytes: activation and desensitization by prostaglandins and 1-epinephrine. Proc Natl Acad Sci U S A. 1975 Aug;72(8):3124–3128. doi: 10.1073/pnas.72.8.3124. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Steinman R. M., Cohn Z. A. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med. 1973 May 1;137(5):1142–1162. doi: 10.1084/jem.137.5.1142. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Werb Z., Mainardi C. L., Vater C. A., Harris E. D., Jr Endogenous activiation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator. N Engl J Med. 1977 May 5;296(18):1017–1023. doi: 10.1056/NEJM197705052961801. [DOI] [PubMed] [Google Scholar]
