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. 2001 Aug;109(8):757–764. doi: 10.1289/ehp.01109757

Vaccine-induced antibody responses as parameters of the influence of endogenous and environmental factors.

H Van Loveren 1, J G Van Amsterdam 1, R J Vandebriel 1, T G Kimman 1, H C Rümke 1, P S Steerenberg 1, J G Vos 1
PMCID: PMC1240401  PMID: 11564609

Abstract

In laboratory animals, an adequate way to assess effects of environmental exposures on the immune system is to study effects on antigen-specific immune responses, such as after sensitization to T-cell-dependent antigens. This probably also applies to testing effects in the human population. It has thus been suggested that antibody responses to vaccination might be useful in this context. Vaccination responses may be influenced by a variety of factors other than environmental ones. One factor is the vaccine itself; a second is the vaccination procedure used. In addition, the intrinsic capacity of the recipient to respond to a vaccine, which is determined by sex, genetic factors, and age, is important. Psychological stress, nutrition, and (infectious) diseases are also likely to have an impact. We reviewed the literature on vaccine response. With regard to exogenous factors, there is good evidence that smoking, diet, psychological stress, and certain infectious diseases affect vaccination titers, although it is difficult to determine to what extent. Genetic factors render certain individuals nonresponsive to vaccination. In general, in epidemiologic studies of adverse effects of exposure to agents in the environment in which vaccination titers are used, these additional factors need to be taken into consideration. Provided that these factors are corrected for, a study that shows an association of exposure to a given agent with diminished vaccination responses may indicate suboptimal function of the immune system and clinically relevant diminished immune response. It is quite unlikely that environmental exposures that affect responses to vaccination may in fact abrogate protection to the specific pathogen for which vaccination was performed. Only in those cases where individuals have a poor response to the vaccine may exogenous factors perhaps have a clinically significant influence on resistance to the specific pathogen. An exposure-associated inhibition of a vaccination response may, however, signify a decreased host resistance to pathogens against which no vaccination had been performed.

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Selected References

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  1. Actor J. K., Shirai M., Kullberg M. C., Buller R. M., Sher A., Berzofsky J. A. Helminth infection results in decreased virus-specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance. Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):948–952. doi: 10.1073/pnas.90.3.948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Adeiga A. A., Akinosho R. O., Onyewuche J. Evaluation of immune response in infants with different nutritional status: vaccinated against tuberculosis, measles and poliomyelitis. J Trop Pediatr. 1994 Dec;40(6):345–350. doi: 10.1093/tropej/40.6.345. [DOI] [PubMed] [Google Scholar]
  3. Alper C. A., Kruskall M. S., Marcus-Bagley D., Craven D. E., Katz A. J., Brink S. J., Dienstag J. L., Awdeh Z., Yunis E. J. Genetic prediction of nonresponse to hepatitis B vaccine. N Engl J Med. 1989 Sep 14;321(11):708–712. doi: 10.1056/NEJM198909143211103. [DOI] [PubMed] [Google Scholar]
  4. Arnold D. L., Bryce F., Karpinski K., Mes J., Fernie S., Tryphonas H., Truelove J., McGuire P. F., Burns D., Tanner J. R. Toxicological consequences of Aroclor 1254 ingestion by female rhesus (Macaca mulatta) monkeys. Part 1B. Prebreeding phase: clinical and analytical laboratory findings. Food Chem Toxicol. 1993 Nov;31(11):811–824. doi: 10.1016/0278-6915(93)90219-o. [DOI] [PubMed] [Google Scholar]
  5. Arpadi S. M., Markowitz L. E., Baughman A. L., Shah K., Adam H., Wiznia A., Lambert G., Dobroszycki J., Heath J. L., Bellini W. J. Measles antibody in vaccinated human immunodeficiency virus type 1-infected children. Pediatrics. 1996 May;97(5):653–657. [PubMed] [Google Scholar]
  6. Balloni A., Assael B. M., Ghio L., Pedrazzi C., Nebbia G., Gridelli B., Melada E., Panuccio A., Foti M., Barbi M. Immunity to poliomyelitis, diphtheria and tetanus in pediatric patients before and after renal or liver transplantation. Vaccine. 1999 Jun 4;17(20-21):2507–2511. doi: 10.1016/s0264-410x(99)00064-x. [DOI] [PubMed] [Google Scholar]
  7. Bell A. F., Burns J. B., Fujinami R. S. Measles virus infection of human T cells modulates cytokine generation and IL-2 receptor alpha chain expression. Virology. 1997 Jun 9;232(2):241–247. doi: 10.1006/viro.1997.8577. [DOI] [PubMed] [Google Scholar]
  8. Bendich A. Antioxidant vitamins and human immune responses. Vitam Horm. 1996;52:35–62. doi: 10.1016/s0083-6729(08)60406-9. [DOI] [PubMed] [Google Scholar]
  9. Beyer W. E., Palache A. M., Baljet M., Masurel N. Antibody induction by influenza vaccines in the elderly: a review of the literature. Vaccine. 1989 Oct;7(5):385–394. doi: 10.1016/0264-410x(89)90150-3. [DOI] [PubMed] [Google Scholar]
  10. Booy R., Aitken S. J., Taylor S., Tudor-Williams G., Macfarlane J. A., Moxon E. R., Ashworth L. A., Mayon-White R. T., Griffiths H., Chapel H. M. Immunogenicity of combined diphtheria, tetanus, and pertussis vaccine given at 2, 3, and 4 months versus 3, 5, and 9 months of age. Lancet. 1992 Feb 29;339(8792):507–510. doi: 10.1016/0140-6736(92)90336-2. [DOI] [PubMed] [Google Scholar]
  11. Bouchaud O., Mouas H. Vaccinations et maladies systémiques. Vaccinations et immunodépression. Ann Med Interne (Paris) 1998 Oct;149(6):351–360. [PubMed] [Google Scholar]
  12. Brandriss M. W., Betts R. F., Mathur U., Douglas R. G., Jr Responses of elderly subjects to monovalent A/USSR/77 (H1N1) and Trivalent A/USSR/77 (H1N1)-A/TEXAS/77 (H3N2)-B/Hong Kong/72 vaccines. Am Rev Respir Dis. 1981 Dec;124(6):681–684. doi: 10.1164/arrd.1981.124.6.681. [DOI] [PubMed] [Google Scholar]
  13. Brenan M., Zinkernagel R. M. Influence of one virus infection on a second concurrent primary in vivo antiviral cytotoxic T-cell response. Infect Immun. 1983 Aug;41(2):470–475. doi: 10.1128/iai.41.2.470-475.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Burns E. A., Lum L. G., L'Hommedieu G., Goodwin J. S. Specific humoral immunity in the elderly: in vivo and in vitro response to vaccination. J Gerontol. 1993 Nov;48(6):B231–B236. doi: 10.1093/geronj/48.6.b231. [DOI] [PubMed] [Google Scholar]
  15. Caillat-Zucman S., Gimenez J. J., Wambergue F., Albouze G., Lebkiri B., Naret C., Moynot A., Jungers P., Bach J. F. Distinct HLA class II alleles determine antibody response to vaccination with hepatitis B surface antigen. Kidney Int. 1998 Jun;53(6):1626–1630. doi: 10.1046/j.1523-1755.1998.00909.x. [DOI] [PubMed] [Google Scholar]
  16. Calder P. C. n-3 polyunsaturated fatty acids and cytokine production in health and disease. Ann Nutr Metab. 1997;41(4):203–234. doi: 10.1159/000177997. [DOI] [PubMed] [Google Scholar]
  17. Cason J., Ainley C. C., Wolstencroft R. A., Norton K. R., Thompson R. P. Cell-mediated immunity in anorexia nervosa. Clin Exp Immunol. 1986 May;64(2):370–375. [PMC free article] [PubMed] [Google Scholar]
  18. De Swart R. L., Ross P. S., Timmerman H. H., Vos H. W., Reijnders P. J., Vos J. G., Osterhaus A. D. Impaired cellular immune response in harbour seals (Phoca vitulina) feeding on environmentally contaminated herring. Clin Exp Immunol. 1995 Sep;101(3):480–486. doi: 10.1111/j.1365-2249.1995.tb03138.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Dennehy P. H., Saracen C. L., Peter G. Seroconversion rates to combined measles-mumps-rubella-varicella vaccine of children with upper respiratory tract infection. Pediatrics. 1994 Oct;94(4 Pt 1):514–516. [PubMed] [Google Scholar]
  20. Deseda-Tous J., Cherry J. D., Spencer M. J., Welliver R. C., Boyer K. M., Dudley J. P., Zahradnik J. M., Krause P. J., Walbergh E. W. Measles revaccination. Persistence and degree of antibody titer by type of immune response. Am J Dis Child. 1978 Mar;132(3):287–290. doi: 10.1001/archpedi.1978.02120280071015. [DOI] [PubMed] [Google Scholar]
  21. Desombere I., Willems A., Leroux-Roels G. Response to hepatitis B vaccine: multiple HLA genes are involved. Tissue Antigens. 1998 Jun;51(6):593–604. doi: 10.1111/j.1399-0039.1998.tb03001.x. [DOI] [PubMed] [Google Scholar]
  22. Dietz V., Galazka A., van Loon F., Cochi S. Factors affecting the immunogenicity and potency of tetanus toxoid: implications for the elimination of neonatal and non-neonatal tetanus as public health problems. Bull World Health Organ. 1997;75(1):81–93. [PMC free article] [PubMed] [Google Scholar]
  23. Edmonson M. B., Davis J. P., Hopfensperger D. J., Berg J. L., Payton L. A. Measles vaccination during the respiratory virus season and risk of vaccine failure. Pediatrics. 1996 Nov;98(5):905–910. [PubMed] [Google Scholar]
  24. Faden H., Duffy L. Effect of concurrent viral infection on systemic and local antibody responses to live attenuated and enhanced-potency inactivated poliovirus vaccines. Am J Dis Child. 1992 Nov;146(11):1320–1323. doi: 10.1001/archpedi.1992.02160230078023. [DOI] [PubMed] [Google Scholar]
  25. Fagiolo U., Amadori A., Cozzi E., Bendo R., Lama M., Douglas A., Palù G. Humoral and cellular immune response to influenza virus vaccination in aged humans. Aging (Milano) 1993 Dec;5(6):451–458. doi: 10.1007/BF03324202. [DOI] [PubMed] [Google Scholar]
  26. Fugier-Vivier I., Servet-Delprat C., Rivailler P., Rissoan M. C., Liu Y. J., Rabourdin-Combe C. Measles virus suppresses cell-mediated immunity by interfering with the survival and functions of dendritic and T cells. J Exp Med. 1997 Sep 15;186(6):813–823. doi: 10.1084/jem.186.6.813. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Gerritsen E. J., Van Tol M. J., Van 't Veer M. B., Wels J. M., Khouw I. M., Touw C. R., Jol-Van Der Zijde C. M., Hermans J., Rümke H. C., Radl J. Clonal dysregulation of the antibody response to tetanus-toxoid after bone marrow transplantation. Blood. 1994 Dec 15;84(12):4374–4382. [PubMed] [Google Scholar]
  28. Glaser R., Kiecolt-Glaser J. K., Bonneau R. H., Malarkey W., Kennedy S., Hughes J. Stress-induced modulation of the immune response to recombinant hepatitis B vaccine. Psychosom Med. 1992 Jan-Feb;54(1):22–29. doi: 10.1097/00006842-199201000-00005. [DOI] [PubMed] [Google Scholar]
  29. Golla J. A., Larson L. A., Anderson C. F., Lucas A. R., Wilson W. R., Tomasi T. B., Jr An immunological assessment of patients with anorexia nervosa. Am J Clin Nutr. 1981 Dec;34(12):2756–2762. doi: 10.1093/ajcn/34.12.2756. [DOI] [PubMed] [Google Scholar]
  30. Gravenstein S., Miller B. A., Drinka P. Prevention and control of influenza A outbreaks in long-term care facilities. Infect Control Hosp Epidemiol. 1992 Jan;13(1):49–54. doi: 10.1086/646422. [DOI] [PubMed] [Google Scholar]
  31. Gross P. A., Quinnan G. V., Jr, Weksler M. E., Gaerlan P. F., Denning C. R. Immunization of elderly people with high doses of influenza vaccine. J Am Geriatr Soc. 1988 Mar;36(3):209–212. doi: 10.1111/j.1532-5415.1988.tb01802.x. [DOI] [PubMed] [Google Scholar]
  32. Hadler S. C., Francis D. P., Maynard J. E., Thompson S. E., Judson F. N., Echenberg D. F., Ostrow D. G., O'Malley P. M., Penley K. A., Altman N. L. Long-term immunogenicity and efficacy of hepatitis B vaccine in homosexual men. N Engl J Med. 1986 Jul 24;315(4):209–214. doi: 10.1056/NEJM198607243150401. [DOI] [PubMed] [Google Scholar]
  33. Halsey N. A., Boulos R., Mode F., Andre J., Bowman L., Yaeger R. G., Toureau S., Rohde J., Boulos C. Response to measles vaccine in Haitian infants 6 to 12 months old. Influence of maternal antibodies, malnutrition, and concurrent illnesses. N Engl J Med. 1985 Aug 29;313(9):544–549. doi: 10.1056/NEJM198508293130904. [DOI] [PubMed] [Google Scholar]
  34. Halsey N., Galazka A. The efficacy of DPT and oral poliomyelitis immunization schedules initiated from birth to 12 weeks of age. Bull World Health Organ. 1985;63(6):1151–1169. [PMC free article] [PubMed] [Google Scholar]
  35. Hayney M. S., Poland G. A., Dimanlig P., Schaid D. J., Jacobson R. M., Lipsky J. J. Polymorphisms of the TAP2 gene may influence antibody response to live measles vaccine virus. Vaccine. 1997 Jan;15(1):3–6. doi: 10.1016/s0264-410x(96)00133-8. [DOI] [PubMed] [Google Scholar]
  36. Hayney M. S., Poland G. A., Jacobson R. M., Rabe D., Schaid D. J., Jacobsen S. J., Lipsky J. J. Relationship of HLA-DQA1 alleles and humoral antibody following measles vaccination. Int J Infect Dis. 1998 Jan-Mar;2(3):143–146. doi: 10.1016/s1201-9712(98)90116-3. [DOI] [PubMed] [Google Scholar]
  37. Hayney M. S., Poland G. A., Jacobson R. M., Schaid D. J., Lipsky J. J. The influence of the HLA-DRB1*13 allele on measles vaccine response. J Investig Med. 1996 Jun;44(5):261–263. [PubMed] [Google Scholar]
  38. Huzly D., Neifer S., Reinke P., Schröder K., Schönfeld C., Hofmann T., Bienzle U. Routine immunizations in adult renal transplant recipients. Transplantation. 1997 Mar 27;63(6):839–845. doi: 10.1097/00007890-199703270-00008. [DOI] [PubMed] [Google Scholar]
  39. Höhler T., Meyer C. U., Notghi A., Stradmann-Bellinghausen B., Schneider P. M., Starke R., Zepp F., Sänger R., Clemens R., Meyer zum Büschenfelde K. H. The influence of major histocompatibility complex class II genes and T-cell Vbeta repertoire on response to immunization with HBsAg. Hum Immunol. 1998 Apr;59(4):212–218. doi: 10.1016/s0198-8859(98)00014-7. [DOI] [PubMed] [Google Scholar]
  40. Ifekwunigwe A. E., Grasset N., Glass R., Foster S. Immune responses to measles and smallpox vaccinations in malnourished children. Am J Clin Nutr. 1980 Mar;33(3):621–624. doi: 10.1093/ajcn/33.3.621. [DOI] [PubMed] [Google Scholar]
  41. Jabaaij L., Grosheide P. M., Heijtink R. A., Duivenvoorden H. J., Ballieux R. E., Vingerhoets A. J. Influence of perceived psychological stress and distress on antibody response to low dose rDNA hepatitis B vaccine. J Psychosom Res. 1993 May;37(4):361–369. doi: 10.1016/0022-3999(93)90138-6. [DOI] [PubMed] [Google Scholar]
  42. Jabaaij L., van Hattum J., Vingerhoets J. J., Oostveen F. G., Duivenvoorden H. J., Ballieux R. E. Modulation of immune response to rDNA hepatitis B vaccination by psychological stress. J Psychosom Res. 1996 Aug;41(2):129–137. doi: 10.1016/0022-3999(96)00123-7. [DOI] [PubMed] [Google Scholar]
  43. Karp C. L., Wysocka M., Wahl L. M., Ahearn J. M., Cuomo P. J., Sherry B., Trinchieri G., Griffin D. E. Mechanism of suppression of cell-mediated immunity by measles virus. Science. 1996 Jul 12;273(5272):228–231. doi: 10.1126/science.273.5272.228. [DOI] [PubMed] [Google Scholar]
  44. Kelley D. S., Bendich A. Essential nutrients and immunologic functions. Am J Clin Nutr. 1996 Jun;63(6):994S–996S. doi: 10.1093/ajcn/63.6.994. [DOI] [PubMed] [Google Scholar]
  45. Keren G., Segev S., Morag A., Zakay-Rones Z., Barzilai A., Rubinstein E. Failure of influenza vaccination in the aged. J Med Virol. 1988 May;25(1):85–89. doi: 10.1002/jmv.1890250112. [DOI] [PubMed] [Google Scholar]
  46. Kiecolt-Glaser J. K., Glaser R., Gravenstein S., Malarkey W. B., Sheridan J. Chronic stress alters the immune response to influenza virus vaccine in older adults. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3043–3047. doi: 10.1073/pnas.93.7.3043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Kielmann A. A., Uberoi I. S., Chandra R. K., Mehra V. L. The effect of nutritional status on immune capacity and immune responses in preschool children in a rural community in India. Bull World Health Organ. 1976;54(5):477–483. [PMC free article] [PubMed] [Google Scholar]
  48. Kim J. H., Perfect J. R. Infection and cyclosporine. Rev Infect Dis. 1989 Sep-Oct;11(5):677–690. doi: 10.1093/clinids/11.5.677. [DOI] [PubMed] [Google Scholar]
  49. Kotwal G. J. Microorganisms and their interaction with the immune system. J Leukoc Biol. 1997 Oct;62(4):415–429. doi: 10.1002/jlb.62.4.415. [DOI] [PubMed] [Google Scholar]
  50. Langö-Warensjö A., Cardell K., Lindblom B. Haplotypes comprising subtypes of the DQB1*06 allele direct the antibody response after immunisation with hepatitis B surface antigen. Tissue Antigens. 1998 Oct;52(4):374–380. doi: 10.1111/j.1399-0039.1998.tb03058.x. [DOI] [PubMed] [Google Scholar]
  51. Lesourd B. M. Nutrition and immunity in the elderly: modification of immune responses with nutritional treatments. Am J Clin Nutr. 1997 Aug;66(2):478S–484S. doi: 10.1093/ajcn/66.2.478S. [DOI] [PubMed] [Google Scholar]
  52. Lesourd B. Protein undernutrition as the major cause of decreased immune function in the elderly: clinical and functional implications. Nutr Rev. 1995 Apr;53(4 Pt 2):S86–S94. doi: 10.1111/j.1753-4887.1995.tb01523.x. [DOI] [PubMed] [Google Scholar]
  53. Ligthart G. J., Corberand J. X., Fournier C., Galanaud P., Hijmans W., Kennes B., Müller-Hermelink H. K., Steinmann G. G. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech Ageing Dev. 1984 Nov;28(1):47–55. doi: 10.1016/0047-6374(84)90152-0. [DOI] [PubMed] [Google Scholar]
  54. Livingston B. D., Alexander J., Crimi C., Oseroff C., Celis E., Daly K., Guidotti L. G., Chisari F. V., Fikes J., Chesnut R. W. Altered helper T lymphocyte function associated with chronic hepatitis B virus infection and its role in response to therapeutic vaccination in humans. J Immunol. 1999 Mar 1;162(5):3088–3095. [PubMed] [Google Scholar]
  55. Loke R. H., Murray-Lyon I. M., Coleman J. C., Evans B. A., Zuckerman A. J. Diminished response to recombinant hepatitis B vaccine in homosexual men with HIV antibody: an indicator of poor prognosis. J Med Virol. 1990 Jun;31(2):109–111. doi: 10.1002/jmv.1890310207. [DOI] [PubMed] [Google Scholar]
  56. Luster M. I., Portier C., Pait D. G., Rosenthal G. J., Germolec D. R., Corsini E., Blaylock B. L., Pollock P., Kouchi Y., Craig W. Risk assessment in immunotoxicology. II. Relationships between immune and host resistance tests. Fundam Appl Toxicol. 1993 Jul;21(1):71–82. doi: 10.1006/faat.1993.1074. [DOI] [PubMed] [Google Scholar]
  57. Luster M. I., Portier C., Pait D. G., White K. L., Jr, Gennings C., Munson A. E., Rosenthal G. J. Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests. Fundam Appl Toxicol. 1992 Feb;18(2):200–210. doi: 10.1016/0272-0590(92)90047-l. [DOI] [PubMed] [Google Scholar]
  58. Maldonado Y. A., Peña-Cruz V., de la Luz Sanchez M., Logan L., Blandón S., Cantwell M. F., Matsui S. M., Millan-Velasco F., Valdespino J. L., Sepulveda J. Host and viral factors affecting the decreased immunogenicity of Sabin type 3 vaccine after administration of trivalent oral polio vaccine to rural Mayan children. J Infect Dis. 1997 Mar;175(3):545–553. doi: 10.1093/infdis/175.3.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Marcos A., Varela P., Toro O., López-Vidriero I., Nova E., Madruga D., Casas J., Morandé G. Interactions between nutrition and immunity in anorexia nervosa: a 1-y follow-up study. Am J Clin Nutr. 1997 Aug;66(2):485S–490S. doi: 10.1093/ajcn/66.2.485S. [DOI] [PubMed] [Google Scholar]
  60. Marcos A., Varela P., Toro O., Nova E., López-Vidriero I., Morandé G. Evaluation of nutritional status by immunologic assessment in bulimia nervosa: influence of body mass index and vomiting episodes. Am J Clin Nutr. 1997 Aug;66(2):491S–497S. doi: 10.1093/ajcn/66.2.491S. [DOI] [PubMed] [Google Scholar]
  61. Martinetti M., Cuccia M., Daielli C., Ambroselli F., Gatti C., Pizzochero C., Belloni C., Orsolini P., Salvaneschi L. Anti-HBV neonatal immunization with recombinant vaccine. Part II. Molecular basis of the impaired alloreactivity. Vaccine. 1995 Apr;13(6):555–560. doi: 10.1016/0264-410x(94)00044-n. [DOI] [PubMed] [Google Scholar]
  62. McDermott A. B., Zuckerman J. N., Sabin C. A., Marsh S. G., Madrigal J. A. Contribution of human leukocyte antigens to the antibody response to hepatitis B vaccination. Tissue Antigens. 1997 Jul;50(1):8–14. doi: 10.1111/j.1399-0039.1997.tb02827.x. [DOI] [PubMed] [Google Scholar]
  63. Meydani S. N., Meydani M., Blumberg J. B., Leka L. S., Siber G., Loszewski R., Thompson C., Pedrosa M. C., Diamond R. D., Stollar B. D. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. JAMA. 1997 May 7;277(17):1380–1386. doi: 10.1001/jama.1997.03540410058031. [DOI] [PubMed] [Google Scholar]
  64. Middleton E., Jr, Kandaswami C. Effects of flavonoids on immune and inflammatory cell functions. Biochem Pharmacol. 1992 Mar 17;43(6):1167–1179. doi: 10.1016/0006-2952(92)90489-6. [DOI] [PubMed] [Google Scholar]
  65. Migasena S., Simasathien S., Samakoses R., Pitisuttitham P., Heath J., Bellini W., Bennett J. Adverse impact of infections on antibody responses to measles vaccination. Vaccine. 1998 Apr;16(6):647–652. doi: 10.1016/s0264-410x(97)00229-6. [DOI] [PubMed] [Google Scholar]
  66. Mineta M., Tanimura M., Tana T., Yssel H., Kashiwagi S., Sasazuki T. Contribution of HLA class I and class II alleles to the regulation of antibody production to hepatitis B surface antigen in humans. Int Immunol. 1996 Apr;8(4):525–531. doi: 10.1093/intimm/8.4.525. [DOI] [PubMed] [Google Scholar]
  67. Monjour L., Bourdillon F., Froment A., Claudio-Ribeiro D., Fabre M., Chastang C., Gentilini M. Contribution à l'étude de l'efficacité de la vaccination antirougeoleuse chez le jeune enfant Africain malnutri. Bull Soc Pathol Exot Filiales. 1984 May-Jun;77(3):271–277. [PubMed] [Google Scholar]
  68. Mufson M. A., Hughey D. F., Turner C. E., Schiffman G. Revaccination with pneumococcal vaccine of elderly persons 6 years after primary vaccination. Vaccine. 1991 Jun;9(6):403–407. doi: 10.1016/0264-410x(91)90126-q. [DOI] [PubMed] [Google Scholar]
  69. Panush R. S., Delafuente J. C. Vitamins and immunocompetence. World Rev Nutr Diet. 1985;45:97–132. [PubMed] [Google Scholar]
  70. Petry L. J., Weems L. B., 2nd, Livingstone J. N., 2nd Relationship of stress, distress, and the immunologic response to a recombinant hepatitis B vaccine. J Fam Pract. 1991 May;32(5):481–486. [PubMed] [Google Scholar]
  71. Phair J., Kauffman C. A., Bjornson A., Adams L., Linnemann C., Jr Failure to respond to influenza vaccine in the aged: correlation with B-cell number and function. J Lab Clin Med. 1978 Nov;92(5):822–828. [PubMed] [Google Scholar]
  72. Poland G. A., Jacobson R. M., Colbourne S. A., Thampy A. M., Lipsky J. J., Wollan P. C., Roberts P., Jacobsen S. J. Measles antibody seroprevalence rates among immunized Inuit, Innu and Caucasian subjects. Vaccine. 1999 Mar 17;17(11-12):1525–1531. doi: 10.1016/s0264-410x(98)00362-4. [DOI] [PubMed] [Google Scholar]
  73. Poland G. A., Jacobson R. M., Schaid D., Moore S. B., Jacobsen S. J. The association between HLA class I alleles and measles vaccine-induced antibody response: evidence of a significant association. Vaccine. 1998 Nov;16(19):1869–1871. doi: 10.1016/s0264-410x(98)00017-6. [DOI] [PubMed] [Google Scholar]
  74. Pozzetto B., Odelin M. F., Bienvenu J., Defayolle M., Aymard M. Is there a relationship between malnutrition, inflammation, and post-vaccinal antibody response to influenza viruses in the elderly? J Med Virol. 1993 Sep;41(1):39–43. doi: 10.1002/jmv.1890410109. [DOI] [PubMed] [Google Scholar]
  75. Ratnam S., West R., Gadag V. Measles and rubella antibody response after measles-mumps-rubella vaccination in children with afebrile upper respiratory tract infection. J Pediatr. 1995 Sep;127(3):432–434. doi: 10.1016/s0022-3476(95)70077-3. [DOI] [PubMed] [Google Scholar]
  76. Reigart J. R., Graber C. D. Evaluation of the humoral immune response of children with low lead exposure. Bull Environ Contam Toxicol. 1976 Jul;16(1):112–117. doi: 10.1007/BF01753115. [DOI] [PubMed] [Google Scholar]
  77. Rennels M. B. Influence of breast-feeding and oral poliovirus vaccine on the immunogenicity and efficacy of rotavirus vaccines. J Infect Dis. 1996 Sep;174 (Suppl 1):S107–S111. doi: 10.1093/infdis/174.supplement_1.s107. [DOI] [PubMed] [Google Scholar]
  78. Rink L., Cakman I., Kirchner H. Altered cytokine production in the elderly. Mech Ageing Dev. 1998 May 15;102(2-3):199–209. doi: 10.1016/s0047-6374(97)00153-x. [DOI] [PubMed] [Google Scholar]
  79. Rink L., Seyfarth M. Besonderheiten immunologischer Untersuchungsergebnisse im Alter. Z Gerontol Geriatr. 1997 May-Jun;30(3):220–225. [PubMed] [Google Scholar]
  80. Roome A. J., Walsh S. J., Cartter M. L., Hadler J. L. Hepatitis B vaccine responsiveness in Connecticut public safety personnel. JAMA. 1993 Dec 22;270(24):2931–2934. [PubMed] [Google Scholar]
  81. Salk J., Cohen H., Fillastre C., Stoeckel P., Rey J. L., Schlumberger M., Nicolas A., van Steenis G., van Wezel A. L., Triau R. Killed poliovirus antigen titration in humans. Dev Biol Stand. 1978;41:119–132. [PubMed] [Google Scholar]
  82. Sankilampi U., Isoaho R., Bloigu A., Kivelä S. L., Leinonen M. Effect of age, sex and smoking habits on pneumococcal antibodies in an elderly population. Int J Epidemiol. 1997 Apr;26(2):420–427. doi: 10.1093/ije/26.2.420. [DOI] [PubMed] [Google Scholar]
  83. Schattner A., Steinbock M., Tepper R., Schonfeld A., Vaisman N., Hahn T. Tumour necrosis factor production and cell-mediated immunity in anorexia nervosa. Clin Exp Immunol. 1990 Jan;79(1):62–66. doi: 10.1111/j.1365-2249.1990.tb05127.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  84. Schiffrin E. J., Brassart D., Servin A. L., Rochat F., Donnet-Hughes A. Immune modulation of blood leukocytes in humans by lactic acid bacteria: criteria for strain selection. Am J Clin Nutr. 1997 Aug;66(2):515S–520S. doi: 10.1093/ajcn/66.2.515S. [DOI] [PubMed] [Google Scholar]
  85. Scott S., Cutts F. T., Nyandu B. Mild illness at or after measles vaccination does not reduce seroresponse in young children. Vaccine. 1999 Feb 26;17(7-8):837–843. doi: 10.1016/s0264-410x(98)00268-0. [DOI] [PubMed] [Google Scholar]
  86. Scrimshaw N. S., SanGiovanni J. P. Synergism of nutrition, infection, and immunity: an overview. Am J Clin Nutr. 1997 Aug;66(2):464S–477S. doi: 10.1093/ajcn/66.2.464S. [DOI] [PubMed] [Google Scholar]
  87. Shelly M. A., Jacoby H., Riley G. J., Graves B. T., Pichichero M., Treanor J. J. Comparison of pneumococcal polysaccharide and CRM197-conjugated pneumococcal oligosaccharide vaccines in young and elderly adults. Infect Immun. 1997 Jan;65(1):242–247. doi: 10.1128/iai.65.1.242-247.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  88. Sinha D. P., Bang F. B. Protein and calorie malnutrition, cell-mediated immunity, and B.C.G. vaccination in children from rural West Bengal. Lancet. 1976 Sep 11;2(7985):531–534. doi: 10.1016/s0140-6736(76)91791-8. [DOI] [PubMed] [Google Scholar]
  89. Snyder B. K., Roghmann K. J., Sigal L. H. Effect of stress and other biopsychosocial factors on primary antibody response. J Adolesc Health Care. 1990 Nov;11(6):472–479. doi: 10.1016/0197-0070(90)90105-b. [DOI] [PubMed] [Google Scholar]
  90. Steger M. M., Maczek C., Berger P., Grubeck-Loebenstein B. Vaccination against tetanus in the elderly: do recommended vaccination strategies give sufficient protection. Lancet. 1996 Sep 14;348(9029):762–762. doi: 10.1016/S0140-6736(05)65680-2. [DOI] [PubMed] [Google Scholar]
  91. Stein B. E. Vaccinating elderly people. Protecting from avoidable disease. Drugs Aging. 1994 Oct;5(4):242–253. doi: 10.2165/00002512-199405040-00002. [DOI] [PubMed] [Google Scholar]
  92. Tilzey A. J., Palmer S. J., Harrington C., O'Doherty M. J. Hepatitis A vaccine responses in HIV-positive persons with haemophilia. Vaccine. 1996 Aug;14(11):1039–1041. doi: 10.1016/0264-410x(96)00056-4. [DOI] [PubMed] [Google Scholar]
  93. Triki H., Abdallah M. V., Ben Aissa R., Bouratbine A., Ben Ali Kacem M., Bouraoui S., Koubaa C., Zouari S., Mohsni E., Crainic R. Influence of host related factors on the antibody response to trivalent oral polio vaccine in Tunisian infants. Vaccine. 1997 Jul;15(10):1123–1129. doi: 10.1016/s0264-410x(97)00001-7. [DOI] [PubMed] [Google Scholar]
  94. Vedhara K., Cox N. K., Wilcock G. K., Perks P., Hunt M., Anderson S., Lightman S. L., Shanks N. M. Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination. Lancet. 1999 Feb 20;353(9153):627–631. doi: 10.1016/S0140-6736(98)06098-X. [DOI] [PubMed] [Google Scholar]
  95. Virella G., Fourspring K., Hyman B., Haskill-Stroud R., Long L., Virella I., La Via M., Gross A. J., Lopes-Virella M. Immunosuppressive effects of fish oil in normal human volunteers: correlation with the in vitro effects of eicosapentanoic acid on human lymphocytes. Clin Immunol Immunopathol. 1991 Nov;61(2 Pt 1):161–176. doi: 10.1016/s0090-1229(05)80021-2. [DOI] [PubMed] [Google Scholar]
  96. Watanabe H., Okumura M., Hirayama K., Sasazuki T. HLA-Bw54-DR4-DRw53-DQw4 haplotype controls nonresponsiveness to hepatitis-B surface antigen via CD8-positive suppressor T cells. Tissue Antigens. 1990 Aug;36(2):69–74. doi: 10.1111/j.1399-0039.1990.tb01802.x. [DOI] [PubMed] [Google Scholar]
  97. Weiden P. L., Wolf S. B., Breitz H. B., Appelbaum J. W., Seiler C. A., Mallett R., Bjorn M. J., Su F. M., Fer M. F., Salk D. Human anti-mouse antibody suppression with cyclosporin A. Cancer. 1994 Feb 1;73(3 Suppl):1093–1097. doi: 10.1002/1097-0142(19940201)73:3+<1093::aid-cncr2820731349>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  98. Weisglas-Kuperus N., Patandin S., Berbers G. A., Sas T. C., Mulder P. G., Sauer P. J., Hooijkaas H. Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ Health Perspect. 2000 Dec;108(12):1203–1207. doi: 10.1289/ehp.001081203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  99. Weisglas-Kuperus N., Sas T. C., Koopman-Esseboom C., van der Zwan C. W., De Ridder M. A., Beishuizen A., Hooijkaas H., Sauer P. J. Immunologic effects of background prenatal and postnatal exposure to dioxins and polychlorinated biphenyls in Dutch infants. Pediatr Res. 1995 Sep;38(3):404–410. doi: 10.1203/00006450-199509000-00022. [DOI] [PubMed] [Google Scholar]
  100. Wood R. C., MacDonald K. L., White K. E., Hedberg C. W., Hanson M., Osterholm M. T. Risk factors for lack of detectable antibody following hepatitis B vaccination of Minnesota health care workers. JAMA. 1993 Dec 22;270(24):2935–2939. [PubMed] [Google Scholar]
  101. Yu M. L., Hsin J. W., Hsu C. C., Chan W. C., Guo Y. L. The immunologic evaluation of the Yucheng children. Chemosphere. 1998 Oct-Nov;37(9-12):1855–1865. doi: 10.1016/s0045-6535(98)00251-3. [DOI] [PubMed] [Google Scholar]
  102. al-Ramadi B. K., Greene J. M., Meissler J. J., Jr, Eisenstein T. K. Immunosuppression induced by attenuated Salmonella: effect of LPS responsiveness on development of suppression. Microb Pathog. 1992 Apr;12(4):267–278. doi: 10.1016/0882-4010(92)90045-p. [DOI] [PubMed] [Google Scholar]
  103. van der Does-van den Berg A., Hermans J., Nagel J., van Steenis G. Immunity to diphtheria, pertussis, tetanus, and poliomyelitis in children with acute lymphocytic leukemia after cessation of chemotherapy. Pediatrics. 1981 Feb;67(2):222–229. [PubMed] [Google Scholar]
  104. von Hertzen L., Kaprio J., Koskenvuo M., Isoaho R., Saikku P. Humoral immune response to Chlamydia pneumoniae in twin discordant for smoking. J Intern Med. 1998 Sep;244(3):227–234. [PubMed] [Google Scholar]
  105. von Hertzen L., Surcel H. M., Kaprio J., Koskenvuo M., Bloigu A., Leinonen M., Saikku P. Immune responses to Chlamydia pneumoniae in twins in relation to gender and smoking. J Med Microbiol. 1998 May;47(5):441–446. doi: 10.1099/00222615-47-5-441. [DOI] [PubMed] [Google Scholar]

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