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. 2001 Dec;109(12):1291–1299. doi: 10.1289/ehp.011091291

Prenatal exposure of the northern Québec Inuit infants to environmental contaminants.

G Muckle 1, P Ayotte 1, E Dewailly E 1, S W Jacobson 1, J L Jacobson 1
PMCID: PMC1240513  PMID: 11748038

Abstract

The Inuit population residing in Nunavik (northern Québec, Canada) relies on species from the marine food web for subsistence and is therefore exposed to high doses of environmental contaminants such as polychlorinated biphenyls and methylmercury and to a lesser extent lead. In view of the neurotoxic properties of these substances following developmental exposure, we initiated a study on infant development in this remote coastal population. Here we report the magnitude of prenatal exposure to these contaminants and to selective nutrients in Inuit mothers and their newborns who were recruited on the Hudson Bay coast. We conducted interviews during the women's pregnancies and at 1 and 11 months postpartum and collected biological samples for mercury, lead, polychlorinated biphenyls (PCBs), and chlorinated pesticides analyses as well as selenium and N-3 polyunsaturated fatty acids (n3-PUFA). Cord blood, maternal blood, and maternal hair mercury concentrations averaged 18.5 microg/L, 10.4 microg/L, and 3.7 microg/g, respectively, and are similar to those found in the Faroe Islands but lower than those documented in the Seychelles Islands and New Zealand cohorts. Concentrations of PCB congener 153 averaged 86.9, 105.3, and 131.6 microg/kg (lipids) in cord plasma, maternal plasma, and maternal milk, respectively; prenatal exposure to PCBs in the Nunavik cohort is similar to that reported in the Dutch but much lower than those in other Arctic cohorts. Levels of n3-PUFA in plasma phospholipids and selenium in blood are relatively high. The relatively low correlations observed between organochlorine and methylmercury concentrations may make it easier to identify the specific developmental deficits attributable to each toxicant. Similarly, the weak correlations noted between environmental contaminants and nutrients will facilitate the documentation of possible protective effects afforded by either n3-PUFA or selenium against neurotoxic contaminants.

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Selected References

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  1. Amin-Zaki L., Elhassani S., Majeed M. A., Clarkson T. W., Doherty R. A., Greenwood M. R., Giovanoli-Jakubczak T. Perinatal methylmercury poisoning in Iraq. Am J Dis Child. 1976 Oct;130(10):1070–1076. doi: 10.1001/archpedi.1976.02120110032004. [DOI] [PubMed] [Google Scholar]
  2. Bang H. O., Dyerberg J., Hjøorne N. The composition of food consumed by Greenland Eskimos. Acta Med Scand. 1976;200(1-2):69–73. doi: 10.1111/j.0954-6820.1976.tb08198.x. [DOI] [PubMed] [Google Scholar]
  3. Barrie L. A., Gregor D., Hargrave B., Lake R., Muir D., Shearer R., Tracey B., Bidleman T. Arctic contaminants: sources, occurrence and pathways. Sci Total Environ. 1992 Jul 15;122(1-2):1–74. doi: 10.1016/0048-9697(92)90245-n. [DOI] [PubMed] [Google Scholar]
  4. Bellinger D. C., Stiles K. M., Needleman H. L. Low-level lead exposure, intelligence and academic achievement: a long-term follow-up study. Pediatrics. 1992 Dec;90(6):855–861. [PubMed] [Google Scholar]
  5. Bellinger D., Leviton A., Waternaux C., Needleman H., Rabinowitz M. Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development. N Engl J Med. 1987 Apr 23;316(17):1037–1043. doi: 10.1056/NEJM198704233161701. [DOI] [PubMed] [Google Scholar]
  6. Bjerregaard P., Hansen J. C. Organochlorines and heavy metals in pregnant women from the Disko Bay area in Greenland. Sci Total Environ. 2000 Jan 17;245(1-3):195–202. doi: 10.1016/s0048-9697(99)00444-1. [DOI] [PubMed] [Google Scholar]
  7. Bjerve K. S., Thoresen L., Bønaa K., Vik T., Johnsen H., Brubakk A. M. Clinical studies with alpha-linolenic acid and long-chain n-3 fatty acids. Nutrition. 1992 Mar-Apr;8(2):130–132. [PubMed] [Google Scholar]
  8. Chen Y. C., Guo Y. L., Hsu C. C., Rogan W. J. Cognitive development of Yu-Cheng ("oil disease") children prenatally exposed to heat-degraded PCBs. JAMA. 1992 Dec 9;268(22):3213–3218. [PubMed] [Google Scholar]
  9. Crawford M. A., Hassam A. G., Williams G. Essential fatty acids and fetal brain growth. Lancet. 1976 Feb 28;1(7957):452–453. doi: 10.1016/s0140-6736(76)91476-8. [DOI] [PubMed] [Google Scholar]
  10. Crump K. S., Kjellström T., Shipp A. M., Silvers A., Stewart A. Influence of prenatal mercury exposure upon scholastic and psychological test performance: benchmark analysis of a New Zealand cohort. Risk Anal. 1998 Dec;18(6):701–713. doi: 10.1023/b:rian.0000005917.52151.e6. [DOI] [PubMed] [Google Scholar]
  11. Darvill T., Lonky E., Reihman J., Stewart P., Pagano J. Prenatal exposure to PCBs and infant performance on the fagan test of infant intelligence. Neurotoxicology. 2000 Dec;21(6):1029–1038. [PubMed] [Google Scholar]
  12. Davidson P. W., Myers G. J., Cox C., Axtell C., Shamlaye C., Sloane-Reeves J., Cernichiari E., Needham L., Choi A., Wang Y. Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles Child Development Study. JAMA. 1998 Aug 26;280(8):701–707. doi: 10.1001/jama.280.8.701. [DOI] [PubMed] [Google Scholar]
  13. Davidson P. W., Myers G. J., Cox C., Shamlaye C. F., Marsh D. O., Tanner M. A., Berlin M., Sloane-Reeves J., Cernichiari E., Choisy O. Longitudinal neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from maternal fish ingestion: outcomes at 19 and 29 months. Neurotoxicology. 1995 Winter;16(4):677–688. [PubMed] [Google Scholar]
  14. Dewailly E., Ayotte P., Bruneau S., Laliberté C., Muir D. C., Norstrom R. J. Inuit exposure to organochlorines through the aquatic food chain in arctic québec. Environ Health Perspect. 1993 Dec;101(7):618–620. doi: 10.1289/ehp.93101618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Dewailly E., Ayotte P., Bruneau S., Lebel G., Levallois P., Weber J. P. Exposure of the Inuit population of Nunavik (Arctic Quebec) to lead and mercury. Arch Environ Health. 2001 Jul-Aug;56(4):350–357. doi: 10.1080/00039890109604467. [DOI] [PubMed] [Google Scholar]
  16. Dewailly E., Ayotte P., Laliberté C., Weber J. P., Gingras S., Nantel A. J. Polychlorinated biphenyl (PCB) and dichlorodiphenyl dichloroethylene (DDE) concentrations in the breast milk of women in Quebec. Am J Public Health. 1996 Sep;86(9):1241–1246. doi: 10.2105/ajph.86.9.1241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Dietrich K. N., Krafft K. M., Bornschein R. L., Hammond P. B., Berger O., Succop P. A., Bier M. Low-level fetal lead exposure effect on neurobehavioral development in early infancy. Pediatrics. 1987 Nov;80(5):721–730. [PubMed] [Google Scholar]
  18. Girard M., Noël F., Dumont C. Varying mercury exposure with varying food source in a James Bay Cree community. Arctic Med Res. 1996 Apr;55(2):69–74. [PubMed] [Google Scholar]
  19. Gladen B. C., Rogan W. J., Hardy P., Thullen J., Tingelstad J., Tully M. Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk. J Pediatr. 1988 Dec;113(6):991–995. doi: 10.1016/s0022-3476(88)80569-9. [DOI] [PubMed] [Google Scholar]
  20. Grandjean P., Budtz-Jørgensen E., White R. F., Jørgensen P. J., Weihe P., Debes F., Keiding N. Methylmercury exposure biomarkers as indicators of neurotoxicity in children aged 7 years. Am J Epidemiol. 1999 Aug 1;150(3):301–305. doi: 10.1093/oxfordjournals.aje.a010002. [DOI] [PubMed] [Google Scholar]
  21. Grandjean P., Weihe P., Jørgensen P. J., Clarkson T., Cernichiari E., Viderø T. Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead. Arch Environ Health. 1992 May-Jun;47(3):185–195. doi: 10.1080/00039896.1992.9938348. [DOI] [PubMed] [Google Scholar]
  22. Grandjean P., Weihe P., White R. F., Debes F., Araki S., Yokoyama K., Murata K., Sørensen N., Dahl R., Jørgensen P. J. Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury. Neurotoxicol Teratol. 1997 Nov-Dec;19(6):417–428. doi: 10.1016/s0892-0362(97)00097-4. [DOI] [PubMed] [Google Scholar]
  23. Greiner R. S., Moriguchi T., Hutton A., Slotnick B. M., Salem N., Jr Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks. Lipids. 1999;34 (Suppl):S239–S243. doi: 10.1007/BF02562305. [DOI] [PubMed] [Google Scholar]
  24. Harada M. Minamata disease: methylmercury poisoning in Japan caused by environmental pollution. Crit Rev Toxicol. 1995;25(1):1–24. doi: 10.3109/10408449509089885. [DOI] [PubMed] [Google Scholar]
  25. Innis S. M. Essential fatty acids in infant nutrition: lessons and limitations from animal studies in relation to studies on infant fatty acid requirements. Am J Clin Nutr. 2000 Jan;71(1 Suppl):238S–244S. doi: 10.1093/ajcn/71.1.238S. [DOI] [PubMed] [Google Scholar]
  26. Jacobson J. L., Fein G. G., Jacobson S. W., Schwartz P. M., Dowler J. K. The transfer of polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs) across the human placenta and into maternal milk. Am J Public Health. 1984 Apr;74(4):378–379. doi: 10.2105/ajph.74.4.378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Jacobson J. L., Jacobson S. W., Humphrey H. E. Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. J Pediatr. 1990 Jan;116(1):38–45. doi: 10.1016/s0022-3476(05)81642-7. [DOI] [PubMed] [Google Scholar]
  28. Jacobson J. L., Jacobson S. W. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med. 1996 Sep 12;335(11):783–789. doi: 10.1056/NEJM199609123351104. [DOI] [PubMed] [Google Scholar]
  29. Jacobson S. W., Fein G. G., Jacobson J. L., Schwartz P. M., Dowler J. K. The effect of intrauterine PCB exposure on visual recognition memory. Child Dev. 1985 Aug;56(4):853–860. [PubMed] [Google Scholar]
  30. Marsh D. O., Clarkson T. W., Cox C., Myers G. J., Amin-Zaki L., Al-Tikriti S. Fetal methylmercury poisoning. Relationship between concentration in single strands of maternal hair and child effects. Arch Neurol. 1987 Oct;44(10):1017–1022. doi: 10.1001/archneur.1987.00520220023010. [DOI] [PubMed] [Google Scholar]
  31. McKeown-Eyssen G. E., Ruedy J., Neims A. Methyl mercury exposure in northern Quebec. II. Neurologic findings in children. Am J Epidemiol. 1983 Oct;118(4):470–479. doi: 10.1093/oxfordjournals.aje.a113652. [DOI] [PubMed] [Google Scholar]
  32. Myers G. J., Marsh D. O., Cox C., Davidson P. W., Shamlaye C. F., Tanner M. A., Choi A., Cernichiari E., Choisy O., Clarkson T. W. A pilot neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet. Neurotoxicology. 1995 Winter;16(4):629–638. [PubMed] [Google Scholar]
  33. Myers G. J., Marsh D. O., Davidson P. W., Cox C., Shamlaye C. F., Tanner M., Choi A., Cernichiari E., Choisy O., Clarkson T. W. Main neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet: outcome at six months. Neurotoxicology. 1995 Winter;16(4):653–664. [PubMed] [Google Scholar]
  34. Patandin S., Lanting C. I., Mulder P. G., Boersma E. R., Sauer P. J., Weisglas-Kuperus N. Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age. J Pediatr. 1999 Jan;134(1):33–41. doi: 10.1016/s0022-3476(99)70369-0. [DOI] [PubMed] [Google Scholar]
  35. Phillips D. L., Pirkle J. L., Burse V. W., Bernert J. T., Jr, Henderson L. O., Needham L. L. Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding. Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):495–500. doi: 10.1007/BF01055015. [DOI] [PubMed] [Google Scholar]
  36. Rhainds M., Levallois P., Dewailly E., Ayotte P. Lead, mercury, and organochlorine compound levels in cord blood in Québec, Canada. Arch Environ Health. 1999 Jan-Feb;54(1):40–47. doi: 10.1080/00039899909602235. [DOI] [PubMed] [Google Scholar]
  37. Rogan W. J., Gladen B. C., McKinney J. D., Carreras N., Hardy P., Thullen J., Tinglestad J., Tully M. Neonatal effects of transplacental exposure to PCBs and DDE. J Pediatr. 1986 Aug;109(2):335–341. doi: 10.1016/s0022-3476(86)80397-3. [DOI] [PubMed] [Google Scholar]
  38. Rogan W. J., Gladen B. C. PCBs, DDE, and child development at 18 and 24 months. Ann Epidemiol. 1991 Aug;1(5):407–413. doi: 10.1016/1047-2797(91)90010-a. [DOI] [PubMed] [Google Scholar]
  39. Safe S. H. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol. 1994;24(2):87–149. doi: 10.3109/10408449409049308. [DOI] [PubMed] [Google Scholar]
  40. Smith J. C., Allen P. V., Von Burg R. Hair methylmercury levels in U.S. women. Arch Environ Health. 1997 Nov-Dec;52(6):476–480. doi: 10.1080/00039899709602227. [DOI] [PubMed] [Google Scholar]
  41. Steuerwald U., Weihe P., Jørgensen P. J., Bjerve K., Brock J., Heinzow B., Budtz-Jørgensen E., Grandjean P. Maternal seafood diet, methylmercury exposure, and neonatal neurologic function. J Pediatr. 2000 May;136(5):599–605. doi: 10.1067/mpd.2000.102774. [DOI] [PubMed] [Google Scholar]
  42. Takayama M., Itoh S., Nagasaki T., Tanimizu I. A new enzymatic method for determination of serum choline-containing phospholipids. Clin Chim Acta. 1977 Aug 15;79(1):93–98. doi: 10.1016/0009-8981(77)90465-x. [DOI] [PubMed] [Google Scholar]
  43. Uauy R. D., Birch D. G., Birch E. E., Tyson J. E., Hoffman D. R. Effect of dietary omega-3 fatty acids on retinal function of very-low-birth-weight neonates. Pediatr Res. 1990 Nov;28(5):485–492. doi: 10.1203/00006450-199011000-00014. [DOI] [PubMed] [Google Scholar]
  44. Uauy R., Hoffman D. R. Essential fat requirements of preterm infants. Am J Clin Nutr. 2000 Jan;71(1 Suppl):245S–250S. doi: 10.1093/ajcn/71.1.245S. [DOI] [PubMed] [Google Scholar]
  45. Wasserman G. A., Liu X., Popovac D., Factor-Litvak P., Kline J., Waternaux C., LoIacono N., Graziano J. H. The Yugoslavia Prospective Lead Study: contributions of prenatal and postnatal lead exposure to early intelligence. Neurotoxicol Teratol. 2000 Nov-Dec;22(6):811–818. doi: 10.1016/s0892-0362(00)00106-9. [DOI] [PubMed] [Google Scholar]
  46. Wigg N. R., Vimpani G. V., McMichael A. J., Baghurst P. A., Robertson E. F., Roberts R. J. Port Pirie Cohort study: childhood blood lead and neuropsychological development at age two years. J Epidemiol Community Health. 1988 Sep;42(3):213–219. doi: 10.1136/jech.42.3.213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Yu M. L., Hsu C. C., Gladen B. C., Rogan W. J. In utero PCB/PCDF exposure: relation of developmental delay to dysmorphology and dose. Neurotoxicol Teratol. 1991 Mar-Apr;13(2):195–202. doi: 10.1016/0892-0362(91)90011-k. [DOI] [PubMed] [Google Scholar]

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