Abstract
Our knowledge about the distribution of exposures to toxic chemicals in various communities is limited. Only about 6% of approximately 1,400 toxic chemicals have been identified in surveys. Even for those chemicals that are measured, information is often insufficient to identify smaller populations at high risk. The question is whether information about the distribution of diseases in communities can help identify environmental risks, indicate areas of concern, and thus substitute exposure information. Thyroid disorders represent a large group of diseases that cannot be recorded into registries because of the lack of clear caseness; community-based monitoring of subtle health effects is needed. Thus, to identify potential health risks in communities, epidemiologic studies including effect and human exposure monitoring are necessary. However, to overcome the limitation of nonsystematic case studies, the development of a network of exposed communities concerned about exposures is proposed. A network would provide assessments of exposures and health outcomes, with different communities mutually serving as exposed and control groups. Such a network would foster communication and prevention measures within communities often left out of the dissemination of information about risks identified in studies conducted with residents of these communities.
Full Text
The Full Text of this article is available as a PDF (527.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Asher M. I., Weiland S. K. The International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC Steering Committee. Clin Exp Allergy. 1998 Nov;28 (Suppl 5):52–91. doi: 10.1046/j.1365-2222.1998.028s5052.x. [DOI] [PubMed] [Google Scholar]
- Bahn A. K., Mills J. L., Snyder P. J., Gann P. H., Houten L., Bialik O., Hollmann L., Utiger R. D. Hypothyroidism in workers exposed to polybrominated biphenyls. N Engl J Med. 1980 Jan 3;302(1):31–33. doi: 10.1056/NEJM198001033020105. [DOI] [PubMed] [Google Scholar]
- Bekesi J. G., Roboz J., Anderson H. A., Roboz J. P., Fischbein A. S., Selikoff I. J., Holland J. F. Impaired immune function and identification of polybrominated biphenyls (PBB) in blood compartments of exposed Michigan dairy farmers and chemical workers. Drug Chem Toxicol. 1979;2(1-2):179–191. doi: 10.3109/01480547908993189. [DOI] [PubMed] [Google Scholar]
- Brouwer A., van den Berg K. J. Binding of a metabolite of 3,4,3',4'-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin. Toxicol Appl Pharmacol. 1986 Sep 30;85(3):301–312. doi: 10.1016/0041-008x(86)90337-6. [DOI] [PubMed] [Google Scholar]
- Brown P. Popular epidemiology and toxic waste contamination: lay and professional ways of knowing. J Health Soc Behav. 1992 Sep;33(3):267–281. [PubMed] [Google Scholar]
- Bürgi H., Supersaxo Z., Selz B. Iodine deficiency diseases in Switzerland one hundred years after Theodor Kocher's survey: a historical review with some new goitre prevalence data. Acta Endocrinol (Copenh) 1990 Dec;123(6):577–590. doi: 10.1530/acta.0.1230577. [DOI] [PubMed] [Google Scholar]
- Calvert G. M., Sweeney M. H., Deddens J., Wall D. K. Evaluation of diabetes mellitus, serum glucose, and thyroid function among United States workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Occup Environ Med. 1999 Apr;56(4):270–276. doi: 10.1136/oem.56.4.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Capen C. C. Mechanisms of chemical injury of thyroid gland. Prog Clin Biol Res. 1994;387:173–191. [PubMed] [Google Scholar]
- Capen C. C. Mechanistic data and risk assessment of selected toxic end points of the thyroid gland. Toxicol Pathol. 1997 Jan-Feb;25(1):39–48. doi: 10.1177/019262339702500109. [DOI] [PubMed] [Google Scholar]
- Cheek A. O., Kow K., Chen J., McLachlan J. A. Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. Environ Health Perspect. 1999 Apr;107(4):273–278. doi: 10.1289/ehp.99107273. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Croen L. A., Shaw G. M., Sanbonmatsu L., Selvin S., Buffler P. A. Maternal residential proximity to hazardous waste sites and risk for selected congenital malformations. Epidemiology. 1997 Jul;8(4):347–354. doi: 10.1097/00001648-199707000-00001. [DOI] [PubMed] [Google Scholar]
- Dolk H. The role of the assessment of spatial variation and clustering in environmental surveillance of birth defects. Eur J Epidemiol. 1999 Oct;15(9):839–845. doi: 10.1023/a:1007569831029. [DOI] [PubMed] [Google Scholar]
- Dolk H., Vrijheid M., Armstrong B., Abramsky L., Bianchi F., Garne E., Nelen V., Robert E., Scott J. E., Stone D. Risk of congenital anomalies near hazardous-waste landfill sites in Europe: the EUROHAZCON study. Lancet. 1998 Aug 8;352(9126):423–427. doi: 10.1016/s0140-6736(98)01352-x. [DOI] [PubMed] [Google Scholar]
- Eaton N., Shaddick G., Dolk H., Elliott P. Small-area study of the incidence of neoplasms of the brain and central nervous system among adults in the West Midlands region, 1974-86. Small Area Health Statistics Unit. Br J Cancer. 1997;75(7):1080–1083. doi: 10.1038/bjc.1997.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Elliott P., Briggs D., Morris S., de Hoogh C., Hurt C., Jensen T. K., Maitland I., Richardson S., Wakefield J., Jarup L. Risk of adverse birth outcomes in populations living near landfill sites. BMJ. 2001 Aug 18;323(7309):363–368. doi: 10.1136/bmj.323.7309.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fantini B. La révolution pastorienne et les théories sur l'étiologie du goitre et du crétinisme. Gesnerus. 1992;49(Pt 1):21–38. [PubMed] [Google Scholar]
- Haddow J. E., Palomaki G. E., Allan W. C., Williams J. R., Knight G. J., Gagnon J., O'Heir C. E., Mitchell M. L., Hermos R. J., Waisbren S. E. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med. 1999 Aug 19;341(8):549–555. doi: 10.1056/NEJM199908193410801. [DOI] [PubMed] [Google Scholar]
- Hagmar L., Rylander L., Dyremark E., Klasson-Wehler E., Erfurth E. M. Plasma concentrations of persistent organochlorines in relation to thyrotropin and thyroid hormone levels in women. Int Arch Occup Environ Health. 2001 Apr;74(3):184–188. doi: 10.1007/s004200000213. [DOI] [PubMed] [Google Scholar]
- Henderson A. K., Rosen D., Miller G. L., Figgs L. W., Zahm S. H., Sieber S. M., Rothman N., Humphrey H. E., Sinks T. Breast cancer among women exposed to polybrominated biphenyls. Epidemiology. 1995 Sep;6(5):544–546. doi: 10.1097/00001648-199509000-00014. [DOI] [PubMed] [Google Scholar]
- Hirsch T., Weiland S. K., von Mutius E., Safeca A. F., Gräfe H., Csaplovics E., Duhme H., Keil U., Leupold W. Inner city air pollution and respiratory health and atopy in children. Eur Respir J. 1999 Sep;14(3):669–677. doi: 10.1034/j.1399-3003.1999.14c29.x. [DOI] [PubMed] [Google Scholar]
- Hoque A., Sigurdson A. J., Burau K. D., Humphrey H. E., Hess K. R., Sweeney A. M. Cancer among a Michigan cohort exposed to polybrominated biphenyls in 1973. Epidemiology. 1998 Jul;9(4):373–378. [PubMed] [Google Scholar]
- Hurst J. G., Newcomer W. S., Morrison J. A. Some effects of DDT, toxaphene and polychlorinated biphenyl on thyroid function in Bobwhite quail. Poult Sci. 1974 Jan;53(1):125–133. doi: 10.3382/ps.0530125. [DOI] [PubMed] [Google Scholar]
- Höldke B., Karmaus W., Kruse H. Körperlast an polychlorierten Biphenylen im Vollblut bei 7-10jährigen Kindern in der Umgebung einer Sonderabfallverbrennungsanlage. Gesundheitswesen. 1998 Aug-Sep;60(8-9):505–512. [PubMed] [Google Scholar]
- Karmaus W., DeKoning E. P., Kruse H., Witten J., Osius N. Early childhood determinants of organochlorine concentrations in school-aged children. Pediatr Res. 2001 Sep;50(3):331–336. doi: 10.1203/00006450-200109000-00007. [DOI] [PubMed] [Google Scholar]
- Koopman-Esseboom C., Morse D. C., Weisglas-Kuperus N., Lutkeschipholt I. J., Van der Paauw C. G., Tuinstra L. G., Brouwer A., Sauer P. J. Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants. Pediatr Res. 1994 Oct;36(4):468–473. doi: 10.1203/00006450-199410000-00009. [DOI] [PubMed] [Google Scholar]
- LaKind J. S., Berlin C. M., Naiman D. Q. Infant exposure to chemicals in breast milk in the United States: what we need to learn from a breast milk monitoring program. Environ Health Perspect. 2001 Jan;109(1):75–88. doi: 10.1289/ehp.0110975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Landrigan P. J., Wilcox K. R., Jr, Silva J., Jr, Humphrey H. E., Kauffman C., Heath C. W., Jr Cohort study of Michigan residents exposed to polybrominated biphenyls: epidemiologic and immunologic findings. Ann N Y Acad Sci. 1979 May 31;320:284–294. doi: 10.1111/j.1749-6632.1979.tb56611.x. [DOI] [PubMed] [Google Scholar]
- Langer P., Tajtáková M., Fodor G., Kocan A., Bohov P., Michálek J., Kreze A. Increased thyroid volume and prevalence of thyroid disorders in an area heavily polluted by polychlorinated biphenyls. Eur J Endocrinol. 1998 Oct;139(4):402–409. doi: 10.1530/eje.0.1390402. [DOI] [PubMed] [Google Scholar]
- Lans M. C., Spiertz C., Brouwer A., Koeman J. H. Different competition of thyroxine binding to transthyretin and thyroxine-binding globulin by hydroxy-PCBs, PCDDs and PCDFs. Eur J Pharmacol. 1994 Apr 4;270(2-3):129–136. doi: 10.1016/0926-6917(94)90054-x. [DOI] [PubMed] [Google Scholar]
- Lis G., Pietrzyk J. J. Wpływ zanieczyszczenia powietrza na wystepowanie astmy oskrzelowej u dzieci szkolnych z Krakowa. Pneumonol Alergol Pol. 1997;65(9-10):611–620. [PubMed] [Google Scholar]
- Longnecker M. P., Gladen B. C., Patterson D. G., Jr, Rogan W. J. Polychlorinated biphenyl (PCB) exposure in relation to thyroid hormone levels in neonates. Epidemiology. 2000 May;11(3):249–254. doi: 10.1097/00001648-200005000-00004. [DOI] [PubMed] [Google Scholar]
- Martuzzi M., Grundy C., Elliott P. Perinatal mortality in an English health region: geographical distribution and association with socio-economic factors. Paediatr Perinat Epidemiol. 1998 Jul;12(3):263–276. doi: 10.1046/j.1365-3016.1998.00117.x. [DOI] [PubMed] [Google Scholar]
- McKinney J. D., Waller C. L. Polychlorinated biphenyls as hormonally active structural analogues. Environ Health Perspect. 1994 Mar;102(3):290–297. doi: 10.1289/ehp.94102290. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murai K., Okamura K., Tsuji H., Kajiwara E., Watanabe H., Akagi K., Fujishima M. Thyroid function in "yusho" patients exposed to polychlorinated biphenyls (PCB). Environ Res. 1987 Dec;44(2):179–187. doi: 10.1016/s0013-9351(87)80226-8. [DOI] [PubMed] [Google Scholar]
- Nagayama J., Okamura K., Iida T., Hirakawa H., Matsueda T., Tsuji H., Hasegawa M., Sato K., Ma H. Y., Yanagawa T. Postnatal exposure to chlorinated dioxins and related chemicals on thyroid hormone status in Japanese breast-fed infants. Chemosphere. 1998 Oct-Nov;37(9-12):1789–1793. doi: 10.1016/s0045-6535(98)00244-6. [DOI] [PubMed] [Google Scholar]
- Oppenheimer J. H., Schwartz H. L. Molecular basis of thyroid hormone-dependent brain development. Endocr Rev. 1997 Aug;18(4):462–475. doi: 10.1210/edrv.18.4.0309. [DOI] [PubMed] [Google Scholar]
- Osius N., Karmaus W., Kruse H., Witten J. Exposure to polychlorinated biphenyls and levels of thyroid hormones in children. Environ Health Perspect. 1999 Oct;107(10):843–849. doi: 10.1289/ehp.99107843. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Osius N., Karmaus W. Schilddrüsenhormonspiegel bei Kindern in der Umgebung einer Sonderabfallverbrennungsanlage (SVA) in Südhessen. Gesundheitswesen. 1998 Feb;60(2):107–112. [PubMed] [Google Scholar]
- Pekkanen J., Pearce N. Environmental epidemiology: challenges and opportunities. Environ Health Perspect. 2001 Jan;109(1):1–5. doi: 10.1289/ehp.011091. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pluim H. J., de Vijlder J. J., Olie K., Kok J. H., Vulsma T., van Tijn D. A., van der Slikke J. W., Koppe J. G. Effects of pre- and postnatal exposure to chlorinated dioxins and furans on human neonatal thyroid hormone concentrations. Environ Health Perspect. 1993 Nov;101(6):504–508. doi: 10.1289/ehp.93101504. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Porterfield S. P., Hendrich C. E. The role of thyroid hormones in prenatal and neonatal neurological development--current perspectives. Endocr Rev. 1993 Feb;14(1):94–106. doi: 10.1210/edrv-14-1-94. [DOI] [PubMed] [Google Scholar]
- Porterfield S. P. Vulnerability of the developing brain to thyroid abnormalities: environmental insults to the thyroid system. Environ Health Perspect. 1994 Jun;102 (Suppl 2):125–130. doi: 10.1289/ehp.94102125. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rickenbacher U., McKinney J. D., Oatley S. J., Blake C. C. Structurally specific binding of halogenated biphenyls to thyroxine transport protein. J Med Chem. 1986 May;29(5):641–648. doi: 10.1021/jm00155a010. [DOI] [PubMed] [Google Scholar]
- Rosen D. H., Flanders W. D., Friede A., Humphrey H. E., Sinks T. H. Half-life of polybrominated biphenyl in human sera. Environ Health Perspect. 1995 Mar;103(3):272–274. doi: 10.1289/ehp.95103272. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sauer P. J., Huisman M., Koopman-Esseboom C., Morse D. C., Smits-van Prooije A. E., van de Berg K. J., Tuinstra L. G., van der Paauw C. G., Boersma E. R., Weisglas-Kuperus N. Effects of polychlorinated biphenyls (PCBs) and dioxins on growth and development. Hum Exp Toxicol. 1994 Dec;13(12):900–906. doi: 10.1177/096032719401301213. [DOI] [PubMed] [Google Scholar]
- Schwartz E. M., Rae W. A. Effect of polybrominated biphenyls (PBB) on developmental abilities in young children. Am J Public Health. 1983 Mar;73(3):277–281. doi: 10.2105/ajph.73.3.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seagull E. A. Developmental abilities of children exposed to polybrominated biphenyls (PBB). Am J Public Health. 1983 Mar;73(3):281–285. doi: 10.2105/ajph.73.3.281. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Strauch E., Neupert T., Ihorst G., Storm van's Gravesande K., Bohnet W., Hoeldke B., Karmaus W., Kuehr J. Bronchial hyperresponsiveness to 4.5% hypertonic saline indicates a past history of asthma-like symptoms in children. Pediatr Pulmonol. 2001 Jan;31(1):44–50. doi: 10.1002/1099-0496(200101)31:1<44::aid-ppul1006>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
- Tilson H. A., Kodavanti P. R. Neurochemical effects of polychlorinated biphenyls: an overview and identification of research needs. Neurotoxicology. 1997;18(3):727–743. [PubMed] [Google Scholar]
- Tsuji H., Sato K., Shimono J., Azuma K., Hashiguchi M., Fujishima M. [Thyroid function in patients with Yusho: 28 year follow-up study]. Fukuoka Igaku Zasshi. 1997 May;88(5):231–235. [PubMed] [Google Scholar]
- Wang T. N., Ko Y. C., Chao Y. Y., Huang C. C., Lin R. S. Association between indoor and outdoor air pollution and adolescent asthma from 1995 to 1996 in Taiwan. Environ Res. 1999 Oct;81(3):239–247. doi: 10.1006/enrs.1999.3985. [DOI] [PubMed] [Google Scholar]
