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. 2002 Apr;110(4):419–425. doi: 10.1289/ehp.02110419

Dust mite, cockroach, cat, and dog allergen concentrations in homes of asthmatic children in the northeastern United States: impact of socioeconomic factors and population density.

Brian P Leaderer 1, Kathleen Belanger 1, Elizabeth Triche 1, Theodore Holford 1, Diane R Gold 1, Young Kim 1, Thomas Jankun 1, Ping Ren 1, Jean-ellen McSharry Je 1, Thomas A E Platts-Mills 1, Martin D Chapman 1, Michael B Bracken 1
PMCID: PMC1240806  PMID: 11940461

Abstract

Home exposures to aeroallergens are an important environmental factor in allergic sensitization and in the development and exacerbation of asthma. We assessed variations in home concentrations of dust mite, cockroach, cat, and dog allergens in dust collected in the main living areas of asthmatics' homes by family income, mother's education, dwelling type, population density, household population density, and ethnicity in Connecticut and south-central Massachusetts. Dust samples were collected at the time of home interview in 999 homes as part of an ongoing longitudinal birth cohort study of 1,002 infants and their asthmatic siblings. The analysis employed lower and upper cut points for group 1 dust mite (> or = 2.0 microg/g and > or = 10 microg/g), cockroach (> or = 1.0 U/g and > or = 4.0 U/g), cat (> or = 1.0 microg/g and > or = 8.0 ug/g), and dog (> or = 2.0 microg/g and > or = 10.0 microg/g) allergens. Subject residences were geocoded to assess population density from the U.S. Census, and multiple logistic regression was used to control for confounding. The portion of homes at the lower cut point for dust mite, cockroach, cat, and dog allergens were 46.9%, 24.9%, 42.2%, and 35.6%, respectively; the upper cut point for each of the allergens was reached in 22.4%, 13.4%, 21.0%, and 22.9% of the homes, respectively. In all, 86.0% of the homes had at least one allergen at the lower cut point, and 58.0% had at least one allergen at the upper cut point. Forty-nine percent of the homes had two or more allergens at the lower cut point, and 19.7% had two or more allergens at the upper cut point. Higher education of the mother, higher household income, living in a single-family home in a less densely populated area with fewer people per room, and being a white household were associated with elevated dust mite, cat, and dog allergens and low cockroach allergen. In contrast, low income, living in a multifamily home in a high population density area with a higher occupancy rate per room, and being a Hispanic or black household were associated with elevated cockroach allergens and low concentrations of dust mite, cat, and dog allergens. Although the presence of an individual allergen is more likely associated with one or more socioeconomic or ethnic factors, most homes typically have multiple allergen burdens in excess of concentrations thought to be associated with sensitization and exacerbation of asthma. Mite and cockroach allergens have distinct and opposite associations with socioeconomic factors and population density.

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Selected References

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  1. Beckett W. S., Belanger K., Gent J. F., Holford T. R., Leaderer B. P. Asthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors. Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):894–899. doi: 10.1164/ajrccm.154.4.8887582. [DOI] [PubMed] [Google Scholar]
  2. Call R. S., Smith T. F., Morris E., Chapman M. D., Platts-Mills T. A. Risk factors for asthma in inner city children. J Pediatr. 1992 Dec;121(6):862–866. doi: 10.1016/s0022-3476(05)80329-4. [DOI] [PubMed] [Google Scholar]
  3. Carr W., Zeitel L., Weiss K. Variations in asthma hospitalizations and deaths in New York City. Am J Public Health. 1992 Jan;82(1):59–65. doi: 10.2105/ajph.82.1.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Carter-Pokras O. D., Gergen P. J. Reported asthma among Puerto Rican, Mexican-American, and Cuban children, 1982 through 1984. Am J Public Health. 1993 Apr;83(4):580–582. doi: 10.2105/ajph.83.4.580. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chan-Yeung M., Manfreda J., Dimich-Ward H., Lam J., Ferguson A., Warren P., Simons E., Broder I., Chapman M., Platts-Mills T. Mite and cat allergen levels in homes and severity of asthma. Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1):1805–1811. doi: 10.1164/ajrccm.152.6.8520740. [DOI] [PubMed] [Google Scholar]
  6. Chew G. L., Higgins K. M., Gold D. R., Muilenberg M. L., Burge H. A. Monthly measurements of indoor allergens and the influence of housing type in a northeastern US city. Allergy. 1999 Oct;54(10):1058–1066. doi: 10.1034/j.1398-9995.1999.00003.x. [DOI] [PubMed] [Google Scholar]
  7. Coultas D. B., Gong H., Jr, Grad R., Handler A., McCurdy S. A., Player R., Rhoades E. R., Samet J. M., Thomas A., Westley M. Respiratory diseases in minorities of the United States. Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 2):S93–131. doi: 10.1164/ajrccm/149.3_Pt_2.S93. [DOI] [PubMed] [Google Scholar]
  8. Dust mite allergens and asthma--a worldwide problem. J Allergy Clin Immunol. 1989 Feb;83(2 Pt 1):416–427. doi: 10.1016/0091-6749(89)90128-0. [DOI] [PubMed] [Google Scholar]
  9. Dust mite allergens and asthma--a worldwide problem. J Allergy Clin Immunol. 1989 Feb;83(2 Pt 1):416–427. doi: 10.1016/0091-6749(89)90128-0. [DOI] [PubMed] [Google Scholar]
  10. Eggleston P. A., Buckley T. J., Breysse P. N., Wills-Karp M., Kleeberger S. R., Jaakkola J. J. The environment and asthma in U.S. inner cities. Environ Health Perspect. 1999 Jun;107 (Suppl 3):439–450. doi: 10.1289/ehp.99107s3439. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Eggleston P. A., Rosenstreich D., Lynn H., Gergen P., Baker D., Kattan M., Mortimer K. M., Mitchell H., Ownby D., Slavin R. Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma. J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):563–570. doi: 10.1016/s0091-6749(98)70272-6. [DOI] [PubMed] [Google Scholar]
  12. Evans R., 3rd Asthma among minority children. A growing problem. Chest. 1992 Jun;101(6 Suppl):368S–371S. [PubMed] [Google Scholar]
  13. Gelber L. E., Seltzer L. H., Bouzoukis J. K., Pollart S. M., Chapman M. D., Platts-Mills T. A. Sensitization and exposure to indoor allergens as risk factors for asthma among patients presenting to hospital. Am Rev Respir Dis. 1993 Mar;147(3):573–578. doi: 10.1164/ajrccm/147.3.573. [DOI] [PubMed] [Google Scholar]
  14. Gergen P. J., Mullally D. I., Evans R., 3rd National survey of prevalence of asthma among children in the United States, 1976 to 1980. Pediatrics. 1988 Jan;81(1):1–7. [PubMed] [Google Scholar]
  15. Gergen P. J., Weiss K. B. Changing patterns of asthma hospitalization among children: 1979 to 1987. JAMA. 1990 Oct 3;264(13):1688–1692. [PubMed] [Google Scholar]
  16. Gergen P. J., Weiss K. B. The increasing problem of asthma in the United States. Am Rev Respir Dis. 1992 Oct;146(4):823–824. doi: 10.1164/ajrccm/146.4.823. [DOI] [PubMed] [Google Scholar]
  17. Gold D. R., Rotnitzky A., Damokosh A. I., Ware J. H., Speizer F. E., Ferris B. G., Jr, Dockery D. W. Race and gender differences in respiratory illness prevalence and their relationship to environmental exposures in children 7 to 14 years of age. Am Rev Respir Dis. 1993 Jul;148(1):10–18. doi: 10.1164/ajrccm/148.1.10. [DOI] [PubMed] [Google Scholar]
  18. Ingram J. M., Sporik R., Rose G., Honsinger R., Chapman M. D., Platts-Mills T. A. Quantitative assessment of exposure to dog (Can f 1) and cat (Fel d 1) allergens: relation to sensitization and asthma among children living in Los Alamos, New Mexico. J Allergy Clin Immunol. 1995 Oct;96(4):449–456. doi: 10.1016/s0091-6749(95)70286-5. [DOI] [PubMed] [Google Scholar]
  19. Kitch B. T., Chew G., Burge H. A., Muilenberg M. L., Weiss S. T., Platts-Mills T. A., O'Connor G., Gold D. R. Socioeconomic predictors of high allergen levels in homes in the greater Boston area. Environ Health Perspect. 2000 Apr;108(4):301–307. doi: 10.1289/ehp.00108301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Lang D. M., Polansky M. Patterns of asthma mortality in Philadelphia from 1969 to 1991. N Engl J Med. 1994 Dec 8;331(23):1542–1546. doi: 10.1056/NEJM199412083312302. [DOI] [PubMed] [Google Scholar]
  21. Luczynska C. M., Arruda L. K., Platts-Mills T. A., Miller J. D., Lopez M., Chapman M. D. A two-site monoclonal antibody ELISA for the quantification of the major Dermatophagoides spp. allergens, Der p I and Der f I. J Immunol Methods. 1989 Mar 31;118(2):227–235. doi: 10.1016/0022-1759(89)90010-0. [DOI] [PubMed] [Google Scholar]
  22. Mannino D. M., Homa D. M., Pertowski C. A., Ashizawa A., Nixon L. L., Johnson C. A., Ball L. B., Jack E., Kang D. S. Surveillance for asthma--United States, 1960-1995. MMWR CDC Surveill Summ. 1998 Apr 24;47(1):1–27. [PubMed] [Google Scholar]
  23. Ovsyannikova I. G., Vailes L. D., Li Y., Heymann P. W., Chapman M. D. Monoclonal antibodies to group II Dermatophagoides spp. allergens: murine immune response, epitope analysis, and development of a two-site ELISA. J Allergy Clin Immunol. 1994 Sep;94(3 Pt 1):537–546. doi: 10.1016/0091-6749(94)90211-9. [DOI] [PubMed] [Google Scholar]
  24. Persky V. W., Slezak J., Contreras A., Becker L., Hernandez E., Ramakrishnan V., Piorkowski J. Relationships of race and socioeconomic status with prevalence, severity, and symptoms of asthma in Chicago school children. Ann Allergy Asthma Immunol. 1998 Sep;81(3):266–271. doi: 10.1016/S1081-1206(10)62824-4. [DOI] [PubMed] [Google Scholar]
  25. Pollart S. M., Mullins D. E., Vailes L. D., Hayden M. L., Platts-Mills T. A., Sutherland W. M., Chapman M. D. Identification, quantitation, and purification of cockroach allergens using monoclonal antibodies. J Allergy Clin Immunol. 1991 Feb;87(2):511–521. doi: 10.1016/0091-6749(91)90010-l. [DOI] [PubMed] [Google Scholar]
  26. Ray N. F., Thamer M., Fadillioglu B., Gergen P. J. Race, income, urbanicity, and asthma hospitalization in California: a small area analysis. Chest. 1998 May;113(5):1277–1284. doi: 10.1378/chest.113.5.1277. [DOI] [PubMed] [Google Scholar]
  27. Rosenstreich D. L., Eggleston P., Kattan M., Baker D., Slavin R. G., Gergen P., Mitchell H., McNiff-Mortimer K., Lynn H., Ownby D. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N Engl J Med. 1997 May 8;336(19):1356–1363. doi: 10.1056/NEJM199705083361904. [DOI] [PubMed] [Google Scholar]
  28. Sporik R., Holgate S. T., Platts-Mills T. A., Cogswell J. J. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med. 1990 Aug 23;323(8):502–507. doi: 10.1056/NEJM199008233230802. [DOI] [PubMed] [Google Scholar]
  29. Weiss K. B., Gergen P. J., Wagener D. K. Breathing better or wheezing worse? The changing epidemiology of asthma morbidity and mortality. Annu Rev Public Health. 1993;14:491–513. doi: 10.1146/annurev.pu.14.050193.002423. [DOI] [PubMed] [Google Scholar]
  30. Weiss K. B., Wagener D. K. Asthma surveillance in the United States. A review of current trends and knowledge gaps. Chest. 1990 Nov;98(5 Suppl):179S–184S. [PubMed] [Google Scholar]
  31. Weiss K. B., Wagener D. K. Changing patterns of asthma mortality. Identifying target populations at high risk. JAMA. 1990 Oct 3;264(13):1683–1687. [PubMed] [Google Scholar]
  32. Weiss S. T., Sparrow D., O'Connor G. T. The interrelationship among allergy, airways responsiveness, and asthma. J Asthma. 1993;30(5):329–349. doi: 10.3109/02770909309056738. [DOI] [PubMed] [Google Scholar]
  33. Weitzman M., Gortmaker S. L., Sobol A. M., Perrin J. M. Recent trends in the prevalence and severity of childhood asthma. JAMA. 1992 Nov 18;268(19):2673–2677. [PubMed] [Google Scholar]
  34. Weitzman M., Gortmaker S., Sobol A. Racial, social, and environmental risks for childhood asthma. Am J Dis Child. 1990 Nov;144(11):1189–1194. doi: 10.1001/archpedi.1990.02150350021016. [DOI] [PubMed] [Google Scholar]

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