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. 2002 May;110(5):507–514. doi: 10.1289/ehp.02110507

Residential pesticide use during pregnancy among a cohort of urban minority women.

Robin M Whyatt 1, David E Camann 1, Patrick L Kinney 1, Andria Reyes 1, Judy Ramirez 1, Jessica Dietrich 1, Diurka Diaz 1, Darrell Holmes 1, Frederica P Perera 1
PMCID: PMC1240839  PMID: 12003754

Abstract

Residential pesticide use is widespread in the United States. However, data are limited specific to use among minority populations. Nor are data available on the extent of pesticide exposure resulting from residential use during pregnancy. We have gathered questionnaire data on pesticide use in the home during pregnancy from 316 African-American and Dominican women residing in northern Manhattan and the South Bronx. Additionally, 72 women underwent personal air monitoring for 48 hr during their third trimester of pregnancy to determine exposure levels to 21 pesticides (19 insecticides and 2 fungicides). Of the women questioned, 266 of 314 (85%) reported that pest control measures were used in the home during pregnancy; 111 of 314 (35%) reported that their homes were sprayed by an exterminator, and of those, 45% said the spraying was done more than once per month. Most (>or= 90%) of the pesticide was used for cockroach control. Use of pest control measures increased significantly with the level of housing disrepair reported. Of the women monitored, all (100%) had detectable levels of three insecticides: the organophosphates diazinon (range, 2.0-6,010 ng/m3) and chlorpyrifos (range, 0.7-193 ng/m3) and the carbamate propoxur (range, 3.8-1,380 ng/m3), as well as the fungicide o-phenylphenol (range, 5.7-743 ng/m3). We also frequently detected the following four insecticides (47-83% of samples) but at lower concentrations: the pyrethroid trans-permethrin, piperonyl butoxide (an indicator of exposure to pyrethrins), and the organochlorines 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane and chlordane. Thirty percent of the women had detectable levels of all eight pesticides. Exposures were generally higher among African Americans than among Dominicans. We detected other pesticides in <or= 10% of samples. Results show widespread prenatal pesticide use among minority women in this cohort. Diazinon exposures for some women may have exceeded health-based levels, and our findings support recent federal action to phase out residential use of this insecticide.

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Selected References

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  1. Aldridge W. N. An assessment of the toxicological properties of pyrethroids and their neurotoxicity. Crit Rev Toxicol. 1990;21(2):89–104. doi: 10.3109/10408449009089874. [DOI] [PubMed] [Google Scholar]
  2. Appel K. E. The carcinogenicity of the biocide ortho-phenylphenol. Arch Toxicol. 2000 Apr;74(2):61–71. doi: 10.1007/s002040050654. [DOI] [PubMed] [Google Scholar]
  3. Barr D. B. Exposure to contemporary-use pesticides. J Med Assoc Ga. 1999 Dec;88(4):34–37. [PubMed] [Google Scholar]
  4. Brimijoin S., Koenigsberger C. Cholinesterases in neural development: new findings and toxicologic implications. Environ Health Perspect. 1999 Feb;107 (Suppl 1):59–64. doi: 10.1289/ehp.99107s159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dam K., Seidler F. J., Slotkin T. A. Developmental neurotoxicity of chlorpyrifos: delayed targeting of DNA synthesis after repeated administration. Brain Res Dev Brain Res. 1998 Jun 15;108(1-2):39–45. doi: 10.1016/s0165-3806(98)00028-5. [DOI] [PubMed] [Google Scholar]
  6. Eskenazi B., Bradman A., Castorina R. Exposures of children to organophosphate pesticides and their potential adverse health effects. Environ Health Perspect. 1999 Jun;107 (Suppl 3):409–419. doi: 10.1289/ehp.99107s3409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fullilove M. T., Green L., Fullilove R. E., 3rd Building momentum: an ethnographic study of inner-city redevelopment. Am J Public Health. 1999 Jun;89(6):840–844. doi: 10.2105/ajph.89.6.840. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fullilove M. T., Héon V., Jimenez W., Parsons C., Green L. L., Fullilove R. E. Injury and anomie: effects of violence on an inner-city community. Am J Public Health. 1998 Jun;88(6):924–927. doi: 10.2105/ajph.88.6.924. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Garrett M. H., Hooper B. M., Hooper M. A. Indoor environmental factors associated with house-dust-mite allergen (Der p 1) levels in south-eastern Australian houses. Allergy. 1998 Nov;53(11):1060–1065. doi: 10.1111/j.1398-9995.1998.tb03815.x. [DOI] [PubMed] [Google Scholar]
  10. Gordon S. M., Callahan P. J., Nishioka M. G., Brinkman M. C., O'Rourke M. K., Lebowitz M. D., Moschandreas D. J. Residential environmental measurements in the national human exposure assessment survey (NHEXAS) pilot study in Arizona: preliminary results for pesticides and VOCs. J Expo Anal Environ Epidemiol. 1999 Sep-Oct;9(5):456–470. doi: 10.1038/sj.jea.7500042. [DOI] [PubMed] [Google Scholar]
  11. Gurunathan S., Robson M., Freeman N., Buckley B., Roy A., Meyer R., Bukowski J., Lioy P. J. Accumulation of chlorpyrifos on residential surfaces and toys accessible to children. Environ Health Perspect. 1998 Jan;106(1):9–16. doi: 10.1289/ehp.981069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hill R. H., Jr, Head S. L., Baker S., Gregg M., Shealy D. B., Bailey S. L., Williams C. C., Sampson E. J., Needham L. L. Pesticide residues in urine of adults living in the United States: reference range concentrations. Environ Res. 1995 Nov;71(2):99–108. doi: 10.1006/enrs.1995.1071. [DOI] [PubMed] [Google Scholar]
  13. Johnson D. E., Seidler F. J., Slotkin T. A. Early biochemical detection of delayed neurotoxicity resulting from developmental exposure to chloropyrifos. Brain Res Bull. 1998;45(2):143–147. doi: 10.1016/s0361-9230(97)00329-8. [DOI] [PubMed] [Google Scholar]
  14. Jones A. P. Asthma and domestic air quality. Soc Sci Med. 1998 Sep;47(6):755–764. doi: 10.1016/s0277-9536(98)00151-8. [DOI] [PubMed] [Google Scholar]
  15. Landrigan P. J., Claudio L., Markowitz S. B., Berkowitz G. S., Brenner B. L., Romero H., Wetmur J. G., Matte T. D., Gore A. C., Godbold J. H. Pesticides and inner-city children: exposures, risks, and prevention. Environ Health Perspect. 1999 Jun;107 (Suppl 3):431–437. doi: 10.1289/ehp.99107s3431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Lewis R. G., Fortmann R. C., Camann D. E. Evaluation of methods for monitoring the potential exposure of small children to pesticides in the residential environment. Arch Environ Contam Toxicol. 1994 Jan;26(1):37–46. doi: 10.1007/BF00212792. [DOI] [PubMed] [Google Scholar]
  17. Longnecker M. P., Rogan W. J., Lucier G. The human health effects of DDT (dichlorodiphenyltrichloroethane) and PCBS (polychlorinated biphenyls) and an overview of organochlorines in public health. Annu Rev Public Health. 1997;18:211–244. doi: 10.1146/annurev.publhealth.18.1.211. [DOI] [PubMed] [Google Scholar]
  18. Lu C., Fenske R. A. Dermal transfer of chlorpyrifos residues from residential surfaces: comparison of hand press, hand drag, wipe, and polyurethane foam roller measurements after broadcast and aerosol pesticide applications. Environ Health Perspect. 1999 Jun;107(6):463–467. doi: 10.1289/ehp.99107463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. MacIntosh D. L., Kabiru C. W., Ryan P. B. Longitudinal investigation of dietary exposure to selected pesticides. Environ Health Perspect. 2001 Feb;109(2):145–150. doi: 10.1289/ehp.01109145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. MacIntosh D. L., Kabiru C., Echols S. L., Ryan P. B. Dietary exposure to chlorpyrifos and levels of 3,5,6-trichloro-2-pyridinol in urine. J Expo Anal Environ Epidemiol. 2001 Jul-Aug;11(4):279–285. doi: 10.1038/sj.jea.7500167. [DOI] [PubMed] [Google Scholar]
  21. O'Rourke M. K., Lizardi P. S., Rogan S. P., Freeman N. C., Aguirre A., Saint C. G. Pesticide exposure and creatinine variation among young children. J Expo Anal Environ Epidemiol. 2000 Nov-Dec;10(6 Pt 2):672–681. doi: 10.1038/sj.jea.7500119. [DOI] [PubMed] [Google Scholar]
  22. Rauh Virginia A., Chew Ginger R., Garfinkel Robin S. Deteriorated housing contributes to high cockroach allergen levels in inner-city households. Environ Health Perspect. 2002 Apr;110 (Suppl 2):323–327. doi: 10.1289/ehp.02110s2323. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Shukla Y., Baqar S. M., Mehrotra N. K. Carcinogenicity and co-carcinogenicity studies on propoxur in mouse skin. Food Chem Toxicol. 1998 Dec;36(12):1125–1130. doi: 10.1016/s0278-6915(98)00083-0. [DOI] [PubMed] [Google Scholar]
  24. Slotkin T. A. Developmental cholinotoxicants: nicotine and chlorpyrifos. Environ Health Perspect. 1999 Feb;107 (Suppl 1):71–80. doi: 10.1289/ehp.99107s171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Song X., Seidler F. J., Saleh J. L., Zhang J., Padilla S., Slotkin T. A. Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade. Toxicol Appl Pharmacol. 1997 Jul;145(1):158–174. doi: 10.1006/taap.1997.8171. [DOI] [PubMed] [Google Scholar]
  26. Vijverberg H. P., van den Bercken J. Neurotoxicological effects and the mode of action of pyrethroid insecticides. Crit Rev Toxicol. 1990;21(2):105–126. doi: 10.3109/10408449009089875. [DOI] [PubMed] [Google Scholar]
  27. Whitemore R. W., Immerman F. W., Camann D. E., Bond A. E., Lewis R. G., Schaum J. L. Non-occupational exposures to pesticides for residents of two U.S. cities. Arch Environ Contam Toxicol. 1994 Jan;26(1):47–59. doi: 10.1007/BF00212793. [DOI] [PubMed] [Google Scholar]

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