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. 2002 Aug;110(8):777–782. doi: 10.1289/ehp.02110777

Populations and determinants of airborne fungi in large office buildings.

H Jasmine Chao 1, Joel Schwartz 1, Donald K Milton 1, Harriet A Burge 1
PMCID: PMC1240948  PMID: 12153758

Abstract

Bioaerosol concentrations in office environments and their roles in causing building-related symptoms have drawn much attention in recent years. Most bioaerosol studies have been cross-sectional. We conducted a longitudinal study to examine the characteristics of airborne fungal populations and correlations with other environmental parameters in office environments. We investigated four office buildings in Boston, Massachusetts, during 1 year beginning May 1997, recruiting 21 offices with open workstations. We conducted intensive bioaerosol sampling every 6 weeks resulting in 10 sets of measurement events at each workstation, and recorded relative humidity, temperature, and CO2 concentrations continuously. We used principal component analysis (PCA) to identify groups of culturable fungal taxa that covaried in air. Four major groupings (PCA factors) were derived where the fungal taxa in the same groupings shared similar ecological requirements. Total airborne fungal concentrations varied significantly by season (highest in summer, lowest in winter) and were positively correlated with relative humidity and negatively related to CO2 concentrations. The first and second PCA factors had similar correlations with environmental variables compared with total fungi. The results of this study provide essential information on the variability within airborne fungal populations in office environments over time. These data also provide background against which cross-sectional data can be compared to facilitate interpretation. More studies are needed to correlate airborne fungi and occupants' health, controlling for seasonal effects and other important environmental factors.

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Selected References

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  1. ANDERSEN A. A. New sampler for the collection, sizing, and enumeration of viable airborne particles. J Bacteriol. 1958 Nov;76(5):471–484. doi: 10.1128/jb.76.5.471-484.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Burge H. A. Aerobiology of the indoor environment. Occup Med. 1995 Jan-Mar;10(1):27–40. [PubMed] [Google Scholar]
  3. Burge H. A. Indoor air and infectious disease. Occup Med. 1989 Oct-Dec;4(4):713–721. [PubMed] [Google Scholar]
  4. Burge H. A., Pierson D. L., Groves T. O., Strawn K. F., Mishra S. K. Dynamics of airborne fungal populations in a large office building. Curr Microbiol. 2000 Jan;40(1):10–16. doi: 10.1007/s002849910003. [DOI] [PubMed] [Google Scholar]
  5. Burge H. Bioaerosols: prevalence and health effects in the indoor environment. J Allergy Clin Immunol. 1990 Nov;86(5):687–701. doi: 10.1016/s0091-6749(05)80170-8. [DOI] [PubMed] [Google Scholar]
  6. Cooley J. D., Wong W. C., Jumper C. A., Straus D. C. Correlation between the prevalence of certain fungi and sick building syndrome. Occup Environ Med. 1998 Sep;55(9):579–584. doi: 10.1136/oem.55.9.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dales R. E., Miller D., McMullen E. Indoor air quality and health: validity and determinants of reported home dampness and moulds. Int J Epidemiol. 1997 Feb;26(1):120–125. doi: 10.1093/ije/26.1.120. [DOI] [PubMed] [Google Scholar]
  8. Gravesen S. Fungi as a cause of allergic disease. Allergy. 1979 Jun;34(3):135–154. doi: 10.1111/j.1398-9995.1979.tb01562.x. [DOI] [PubMed] [Google Scholar]
  9. Harrison J., Pickering C. A., Faragher E. B., Austwick P. K., Little S. A., Lawton L. An investigation of the relationship between microbial and particulate indoor air pollution and the sick building syndrome. Respir Med. 1992 May;86(3):225–235. doi: 10.1016/s0954-6111(06)80060-0. [DOI] [PubMed] [Google Scholar]
  10. Hodgson M. The sick-building syndrome. Occup Med. 1995 Jan-Mar;10(1):167–175. [PubMed] [Google Scholar]
  11. Lee J. T., Kim H., Hong Y. C., Kwon H. J., Schwartz J., Christiani D. C. Air pollution and daily mortality in seven major cities of Korea, 1991-1997. Environ Res. 2000 Nov;84(3):247–254. doi: 10.1006/enrs.2000.4096. [DOI] [PubMed] [Google Scholar]
  12. Li C. S., Hsu C. W., Tai M. L. Indoor pollution and sick building syndrome symptoms among workers in day-care centers. Arch Environ Health. 1997 May-Jun;52(3):200–207. doi: 10.1080/00039899709602887. [DOI] [PubMed] [Google Scholar]
  13. Li C. S., Kuo Y. M. Characteristics of airborne microfungi in subtropical homes. Sci Total Environ. 1994 Oct 28;155(3):267–271. doi: 10.1016/0048-9697(94)90505-3. [DOI] [PubMed] [Google Scholar]
  14. Menzies D., Bourbeau J. Building-related illnesses. N Engl J Med. 1997 Nov 20;337(21):1524–1531. doi: 10.1056/NEJM199711203372107. [DOI] [PubMed] [Google Scholar]
  15. Platt S. D., Martin C. J., Hunt S. M., Lewis C. W. Damp housing, mould growth, and symptomatic health state. BMJ. 1989 Jun 24;298(6689):1673–1678. doi: 10.1136/bmj.298.6689.1673. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rao C. Y., Burge H. A., Chang J. C. Review of quantitative standards and guidelines for fungi in indoor air. J Air Waste Manag Assoc. 1996 Sep;46(9):899–908. doi: 10.1080/10473289.1996.10467526. [DOI] [PubMed] [Google Scholar]
  17. Redlich C. A., Sparer J., Cullen M. R. Sick-building syndrome. Lancet. 1997 Apr 5;349(9057):1013–1016. doi: 10.1016/S0140-6736(96)07220-0. [DOI] [PubMed] [Google Scholar]
  18. Schwartz J., Dockery D. W., Neas L. M., Wypij D., Ware J. H., Spengler J. D., Koutrakis P., Speizer F. E., Ferris B. G., Jr Acute effects of summer air pollution on respiratory symptom reporting in children. Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 1):1234–1242. doi: 10.1164/ajrccm.150.5.7952546. [DOI] [PubMed] [Google Scholar]
  19. Skov P. The sick building syndrome. Ann N Y Acad Sci. 1992 Apr 30;641:17–20. doi: 10.1111/j.1749-6632.1992.tb16528.x. [DOI] [PubMed] [Google Scholar]
  20. Skov P., Valbjørn O., Pedersen B. V. Influence of indoor climate on the sick building syndrome in an office environment. The Danish Indoor Climate Study Group. Scand J Work Environ Health. 1990 Oct;16(5):363–371. doi: 10.5271/sjweh.1772. [DOI] [PubMed] [Google Scholar]
  21. Smid T., Schokkin E., Boleij J. S., Heederik D. Enumeration of viable fungi in occupational environments: a comparison of samplers and media. Am Ind Hyg Assoc J. 1989 May;50(5):235–239. doi: 10.1080/15298668991374570. [DOI] [PubMed] [Google Scholar]
  22. Spendlove J. C., Fannin K. F. Source, significance, and control of indoor microbial aerosols: human health aspects. Public Health Rep. 1983 May-Jun;98(3):229–244. [PMC free article] [PubMed] [Google Scholar]
  23. Stolwijk J. A. Sick-building syndrome. Environ Health Perspect. 1991 Nov;95:99–100. doi: 10.1289/ehp.919599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Su H. J., Rotnitzky A., Burge H. A., Spengler J. D. Examination of fungi in domestic interiors by using factor analysis: correlations and associations with home factors. Appl Environ Microbiol. 1992 Jan;58(1):181–186. doi: 10.1128/aem.58.1.181-186.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Verhoeff A. P., Burge H. A. Health risk assessment of fungi in home environments. Ann Allergy Asthma Immunol. 1997 Jun;78(6):544–556. doi: 10.1016/S1081-1206(10)63214-0. [DOI] [PubMed] [Google Scholar]
  26. Verhoeff A. P., van Wijnen J. H., Brunekreef B., Fischer P., van Reenen-Hoekstra E. S., Samson R. A. Presence of viable mould propagules in indoor air in relation to house damp and outdoor air. Allergy. 1992 Apr;47(2 Pt 1):83–91. doi: 10.1111/j.1398-9995.1992.tb05093.x. [DOI] [PubMed] [Google Scholar]

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