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. 2002 Feb;110(Suppl 1):103–112. doi: 10.1289/ehp.02110s1103

Diesel exhaust and asthma: hypotheses and molecular mechanisms of action.

Robert J Pandya 1, Gina Solomon 1, Amy Kinner 1, John R Balmes 1
PMCID: PMC1241152  PMID: 11834468

Abstract

Several components of air pollution have been linked to asthma. In addition to the well-studied critera air pollutants, such as nitrogen dioxide, sulfur dioxide, and ozone, diesel exhaust and diesel exhaust particles (DEPs) also appear to play a role in respiratory and allergic diseases. Diesel exhaust is composed of vapors, gases, and fine particles emitted by diesel-fueled compression-ignition engines. DEPs can act as nonspecific airway irritants at relatively high levels. At lower levels, DEPs promote release of specific cytokines, chemokines, immunoglobulins, and oxidants in the upper and lower airway. Release of these mediators of the allergic and inflammatory response initiates a cascade that can culminate in airway inflammation, mucus secretion, serum leakage into the airways, and bronchial smooth muscle contraction. DEPs also may promote expression of the T(subscript)H(/subscript)2 immunologic response phenotype that has been associated with asthma and allergic disease. DEPs appear to have greater immunologic effects in the presence of environmental allergens than they do alone. This immunologic evidence may help explain the epidemiologic studies indicating that children living along major trucking thoroughfares are at increased risk for asthmatic and allergic symptoms and are more likely to have objective evidence of respiratory dysfunction.

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Selected References

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  1. Abe S., Takizawa H., Sugawara I., Kudoh S. Diesel exhaust (DE)-induced cytokine expression in human bronchial epithelial cells: a study with a new cell exposure system to freshly generated DE in vitro. Am J Respir Cell Mol Biol. 2000 Mar;22(3):296–303. doi: 10.1165/ajrcmb.22.3.3711. [DOI] [PubMed] [Google Scholar]
  2. Azzawi M., Johnston P. W., Majumdar S., Kay A. B., Jeffery P. K. T lymphocytes and activated eosinophils in airway mucosa in fatal asthma and cystic fibrosis. Am Rev Respir Dis. 1992 Jun;145(6):1477–1482. doi: 10.1164/ajrccm/145.6.1477. [DOI] [PubMed] [Google Scholar]
  3. Balmes J. R., Fine J. M., Sheppard D. Symptomatic bronchoconstriction after short-term inhalation of sulfur dioxide. Am Rev Respir Dis. 1987 Nov;136(5):1117–1121. doi: 10.1164/ajrccm/136.5.1117. [DOI] [PubMed] [Google Scholar]
  4. Bayram H., Devalia J. L., Sapsford R. J., Ohtoshi T., Miyabara Y., Sagai M., Davies R. J. The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am J Respir Cell Mol Biol. 1998 Mar;18(3):441–448. doi: 10.1165/ajrcmb.18.3.2882. [DOI] [PubMed] [Google Scholar]
  5. Birnbaum L. S., Slezak B. P. Dietary exposure to PCBs and dioxins in children. Environ Health Perspect. 1999 Jan;107(1):1–1. doi: 10.1289/ehp.107-1566291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Birnbaum L. S., Slezak B. P. Dietary exposure to PCBs and dioxins in children. Environ Health Perspect. 1999 Jan;107(1):1–1. doi: 10.1289/ehp.107-1566291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Birnbaum L. S., Slezak B. P. Dietary exposure to PCBs and dioxins in children. Environ Health Perspect. 1999 Jan;107(1):1–1. doi: 10.1289/ehp.107-1566291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Björkstén B. The environmental influence on childhood asthma. Allergy. 1999;54 (Suppl 49):17–23. doi: 10.1111/j.1398-9995.1999.tb04383.x. [DOI] [PubMed] [Google Scholar]
  9. Boland S., Baeza-Squiban A., Fournier T., Houcine O., Gendron M. C., Chévrier M., Jouvenot G., Coste A., Aubier M., Marano F. Diesel exhaust particles are taken up by human airway epithelial cells in vitro and alter cytokine production. Am J Physiol. 1999 Apr;276(4 Pt 1):L604–L613. doi: 10.1152/ajplung.1999.276.4.L604. [DOI] [PubMed] [Google Scholar]
  10. Boland S., Bonvallot V., Fournier T., Baeza-Squiban A., Aubier M., Marano F. Mechanisms of GM-CSF increase by diesel exhaust particles in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2000 Jan;278(1):L25–L32. doi: 10.1152/ajplung.2000.278.1.L25. [DOI] [PubMed] [Google Scholar]
  11. Brunekreef B., Janssen N. A., de Hartog J., Harssema H., Knape M., van Vliet P. Air pollution from truck traffic and lung function in children living near motorways. Epidemiology. 1997 May;8(3):298–303. doi: 10.1097/00001648-199705000-00012. [DOI] [PubMed] [Google Scholar]
  12. Buchdahl R., Parker A., Stebbings T., Babiker A. Association between air pollution and acute childhood wheezy episodes: prospective observational study. BMJ. 1996 Mar 16;312(7032):661–665. doi: 10.1136/bmj.312.7032.661. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Busse W. W., Lemanske R. F., Jr Asthma. N Engl J Med. 2001 Feb 1;344(5):350–362. doi: 10.1056/NEJM200102013440507. [DOI] [PubMed] [Google Scholar]
  14. Bömmel H., Li-Weber M., Serfling E., Duschl A. The environmental pollutant pyrene induces the production of IL-4. J Allergy Clin Immunol. 2000 Apr;105(4):796–802. doi: 10.1067/mai.2000.105124. [DOI] [PubMed] [Google Scholar]
  15. Calmes D., Leake B. D., Carlisle D. M. Adverse asthma outcomes among children hospitalized with asthma in California. Pediatrics. 1998 May;101(5):845–850. doi: 10.1542/peds.101.5.845. [DOI] [PubMed] [Google Scholar]
  16. Casillas A. M., Hiura T., Li N., Nel A. E. Enhancement of allergic inflammation by diesel exhaust particles: permissive role of reactive oxygen species. Ann Allergy Asthma Immunol. 1999 Dec;83(6 Pt 2):624–629. doi: 10.1016/S1081-1206(10)62884-0. [DOI] [PubMed] [Google Scholar]
  17. Ciccone G., Forastiere F., Agabiti N., Biggeri A., Bisanti L., Chellini E., Corbo G., Dell'Orco V., Dalmasso P., Volante T. F. Road traffic and adverse respiratory effects in children. SIDRIA Collaborative Group. Occup Environ Med. 1998 Nov;55(11):771–778. doi: 10.1136/oem.55.11.771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Clark N. M., Brown R. W., Parker E., Robins T. G., Remick D. G., Jr, Philbert M. A., Keeler G. J., Israel B. A. Childhood asthma. Environ Health Perspect. 1999 Jun;107 (Suppl 3):421–429. doi: 10.1289/ehp.99107s3421. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. D'Amato G. Outdoor air pollution in urban areas and allergic respiratory diseases. Monaldi Arch Chest Dis. 1999 Dec;54(6):470–474. [PubMed] [Google Scholar]
  20. Davies R. J., Rusznak C., Devalia J. L. Why is allergy increasing?--environmental factors. Clin Exp Allergy. 1998 Dec;28 (Suppl 6):8–14. doi: 10.1046/j.1365-2222.1998.0280s6008.x. [DOI] [PubMed] [Google Scholar]
  21. Devalia J. L., Bayram H., Abdelaziz M. M., Sapsford R. J., Davies R. J. Differences between cytokine release from bronchial epithelial cells of asthmatic patients and non-asthmatic subjects: effect of exposure to diesel exhaust particles. Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):437–439. doi: 10.1159/000024157. [DOI] [PubMed] [Google Scholar]
  22. Devalia J. L., Rusznak C., Herdman M. J., Trigg C. J., Tarraf H., Davies R. J. Effect of nitrogen dioxide and sulphur dioxide on airway response of mild asthmatic patients to allergen inhalation. Lancet. 1994 Dec 17;344(8938):1668–1671. doi: 10.1016/s0140-6736(94)90458-8. [DOI] [PubMed] [Google Scholar]
  23. Diaz-Sanchez D., Dotson A. R., Takenaka H., Saxon A. Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms. J Clin Invest. 1994 Oct;94(4):1417–1425. doi: 10.1172/JCI117478. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Diaz-Sanchez D., Garcia M. P., Wang M., Jyrala M., Saxon A. Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa. J Allergy Clin Immunol. 1999 Dec;104(6):1183–1188. doi: 10.1016/s0091-6749(99)70011-4. [DOI] [PubMed] [Google Scholar]
  25. Diaz-Sanchez D. The role of diesel exhaust particles and their associated polyaromatic hydrocarbons in the induction of allergic airway disease. Allergy. 1997;52(38 Suppl):52–58. doi: 10.1111/j.1398-9995.1997.tb04871.x. [DOI] [PubMed] [Google Scholar]
  26. Diaz-Sanchez D., Tsien A., Casillas A., Dotson A. R., Saxon A. Enhanced nasal cytokine production in human beings after in vivo challenge with diesel exhaust particles. J Allergy Clin Immunol. 1996 Jul;98(1):114–123. doi: 10.1016/s0091-6749(96)70233-6. [DOI] [PubMed] [Google Scholar]
  27. Diaz-Sanchez D., Tsien A., Fleming J., Saxon A. Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern. J Immunol. 1997 Mar 1;158(5):2406–2413. [PubMed] [Google Scholar]
  28. Duhme H., Weiland S. K., Keil U., Kraemer B., Schmid M., Stender M., Chambless L. The association between self-reported symptoms of asthma and allergic rhinitis and self-reported traffic density on street of residence in adolescents. Epidemiology. 1996 Nov;7(6):578–582. doi: 10.1097/00001648-199611000-00003. [DOI] [PubMed] [Google Scholar]
  29. Erjefält J. S., Persson C. G. New aspects of degranulation and fates of airway mucosal eosinophils. Am J Respir Crit Care Med. 2000 Jun;161(6):2074–2085. doi: 10.1164/ajrccm.161.6.9906085. [DOI] [PubMed] [Google Scholar]
  30. Fujieda S., Diaz-Sanchez D., Saxon A. Combined nasal challenge with diesel exhaust particles and allergen induces In vivo IgE isotype switching. Am J Respir Cell Mol Biol. 1998 Sep;19(3):507–512. doi: 10.1165/ajrcmb.19.3.3143. [DOI] [PubMed] [Google Scholar]
  31. Fujimaki H., Nohara O., Ichinose T., Watanabe N., Saito S. IL-4 production in mediastinal lymph node cells in mice intratracheally instilled with diesel exhaust particulates and antigen. Toxicology. 1994 Sep 6;92(1-3):261–268. doi: 10.1016/0300-483x(94)90182-1. [DOI] [PubMed] [Google Scholar]
  32. Fujimaki H., Saneyoshi K., Shiraishi F., Imai T., Endo T. Inhalation of diesel exhaust enhances antigen-specific IgE antibody production in mice. Toxicology. 1997 Jan 15;116(1-3):227–233. doi: 10.1016/s0300-483x(96)03539-1. [DOI] [PubMed] [Google Scholar]
  33. Hajat S., Haines A., Goubet S. A., Atkinson R. W., Anderson H. R. Association of air pollution with daily GP consultations for asthma and other lower respiratory conditions in London. Thorax. 1999 Jul;54(7):597–605. doi: 10.1136/thx.54.7.597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Haley K. J., Drazen J. M. Inflammation and airway function in asthma: what you see is not necessarily what you get. Am J Respir Crit Care Med. 1998 Jan;157(1):1–3. doi: 10.1164/ajrccm.157.1.ed-19. [DOI] [PubMed] [Google Scholar]
  35. Hashimoto S., Gon Y., Takeshita I., Matsumoto K., Jibiki I., Takizawa H., Kudoh S., Horie T. Diesel exhaust particles activate p38 MAP kinase to produce interleukin 8 and RANTES by human bronchial epithelial cells and N-acetylcysteine attenuates p38 MAP kinase activation. Am J Respir Crit Care Med. 2000 Jan;161(1):280–285. doi: 10.1164/ajrccm.161.1.9904110. [DOI] [PubMed] [Google Scholar]
  36. Hirsch T., Weiland S. K., von Mutius E., Safeca A. F., Gräfe H., Csaplovics E., Duhme H., Keil U., Leupold W. Inner city air pollution and respiratory health and atopy in children. Eur Respir J. 1999 Sep;14(3):669–677. doi: 10.1034/j.1399-3003.1999.14c29.x. [DOI] [PubMed] [Google Scholar]
  37. Hiura T. S., Kaszubowski M. P., Li N., Nel A. E. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J Immunol. 1999 Nov 15;163(10):5582–5591. [PubMed] [Google Scholar]
  38. Huang J. L., Wang S. Y., Hsieh K. H. Effect of short-term exposure to low levels of SO2 and NOx on pulmonary function and methacholine and allergen bronchial sensitivities in asthmatic children. Arch Environ Health. 1991 Sep-Oct;46(5):296–299. doi: 10.1080/00039896.1991.9934390. [DOI] [PubMed] [Google Scholar]
  39. Ichinose T., Takano H., Miyabara Y., Sagai M. Long-term exposure to diesel exhaust enhances antigen-induced eosinophilic inflammation and epithelial damage in the murine airway. Toxicol Sci. 1998 Jul;44(1):70–79. doi: 10.1006/toxs.1998.2459. [DOI] [PubMed] [Google Scholar]
  40. Ishizaki T., Koizumi K., Ikemori R., Ishiyama Y., Kushibiki E. Studies of prevalence of Japanese cedar pollinosis among the residents in a densely cultivated area. Ann Allergy. 1987 Apr;58(4):265–270. [PubMed] [Google Scholar]
  41. Jenkins H. S., Devalia J. L., Mister R. L., Bevan A. M., Rusznak C., Davies R. J. The effect of exposure to ozone and nitrogen dioxide on the airway response of atopic asthmatics to inhaled allergen: dose- and time-dependent effects. Am J Respir Crit Care Med. 1999 Jul;160(1):33–39. doi: 10.1164/ajrccm.160.1.9808119. [DOI] [PubMed] [Google Scholar]
  42. Jörres R., Magnussen H. Airways response of asthmatics after a 30 min exposure, at resting ventilation, to 0.25 ppm NO2 or 0.5 ppm SO2. Eur Respir J. 1990 Feb;3(2):132–137. [PubMed] [Google Scholar]
  43. Jörres R., Magnussen H. Airways response of asthmatics after a 30 min exposure, at resting ventilation, to 0.25 ppm NO2 or 0.5 ppm SO2. Eur Respir J. 1990 Feb;3(2):132–137. [PubMed] [Google Scholar]
  44. Jörres R., Magnussen H. Airways response of asthmatics after a 30 min exposure, at resting ventilation, to 0.25 ppm NO2 or 0.5 ppm SO2. Eur Respir J. 1990 Feb;3(2):132–137. [PubMed] [Google Scholar]
  45. Kakinoki Y., Ohashi Y., Nakai Y., Washio Y., Nasako Y., Tanaka A., Nakai Y. Allergen induced mRNA expression of interleukin-5, but not of interleukin-4 and interferon-gamma, in peripheral blood mononuclear cells obtained before the pollen season predicts the clinical efficacy of immunotherapy for seasonal allergic rhinitis. Scand J Immunol. 2000 Feb;51(2):202–208. doi: 10.1046/j.1365-3083.2000.00660.x. [DOI] [PubMed] [Google Scholar]
  46. Kemeny D. M. The effects of pollutants on the allergic immune response. Toxicology. 2000 Nov 2;152(1-3):3–12. doi: 10.1016/s0300-483x(00)00286-9. [DOI] [PubMed] [Google Scholar]
  47. Knox R. B., Suphioglu C., Taylor P., Desai R., Watson H. C., Peng J. L., Bursill L. A. Major grass pollen allergen Lol p 1 binds to diesel exhaust particles: implications for asthma and air pollution. Clin Exp Allergy. 1997 Mar;27(3):246–251. [PubMed] [Google Scholar]
  48. Kobayashi T. Exposure to diesel exhaust aggravates nasal allergic reaction in guinea pigs. Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):352–356. doi: 10.1164/ajrccm.162.2.9809035. [DOI] [PubMed] [Google Scholar]
  49. Kobayashi T., Ikeue T., Ito T., Ikeda A., Murakami M., Kato A., Maejima K., Nakajima T., Suzuki T. Short-term exposure to diesel exhaust induces nasal mucosal hyperresponsiveness to histamine in guinea pigs. Fundam Appl Toxicol. 1997 Aug;38(2):166–172. doi: 10.1006/faat.1997.2347. [DOI] [PubMed] [Google Scholar]
  50. Kumagai Y., Taira J., Sagai M. Apparent inhibition of superoxide dismutase activity in vitro by diesel exhaust particles. Free Radic Biol Med. 1995 Feb;18(2):365–371. doi: 10.1016/0891-5849(94)00125-4. [DOI] [PubMed] [Google Scholar]
  51. Lee A. H., Hong J. H., Seo Y. S. Tumour necrosis factor-alpha and interferon-gamma synergistically activate the RANTES promoter through nuclear factor kappaB and interferon regulatory factor 1 (IRF-1) transcription factors. Biochem J. 2000 Aug 15;350(Pt 1):131–138. [PMC free article] [PubMed] [Google Scholar]
  52. Lezcano-Meza D., Teran L. M. Occupational asthma and interleukin-8. Clin Exp Allergy. 1999 Oct;29(10):1301–1303. doi: 10.1046/j.1365-2222.1999.00723.x. [DOI] [PubMed] [Google Scholar]
  53. Lim H. B., Ichinose T., Miyabara Y., Takano H., Kumagai Y., Shimojyo N., Devalia J. L., Sagai M. Involvement of superoxide and nitric oxide on airway inflammation and hyperresponsiveness induced by diesel exhaust particles in mice. Free Radic Biol Med. 1998 Oct;25(6):635–644. doi: 10.1016/s0891-5849(98)00073-2. [DOI] [PubMed] [Google Scholar]
  54. Lipsett M., Hurley S., Ostro B. Air pollution and emergency room visits for asthma in Santa Clara County, California. Environ Health Perspect. 1997 Feb;105(2):216–222. doi: 10.1289/ehp.97105216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Maejima K., Tamura K., Taniguchi Y., Nagase S., Tanaka H. Comparison of the effects of various fine particles on IgE antibody production in mice inhaling Japanese cedar pollen allergens. J Toxicol Environ Health. 1997 Oct 24;52(3):231–248. doi: 10.1080/00984109708984062. [DOI] [PubMed] [Google Scholar]
  56. Mannino D. M., Homa D. M., Pertowski C. A., Ashizawa A., Nixon L. L., Johnson C. A., Ball L. B., Jack E., Kang D. S. Surveillance for asthma--United States, 1960-1995. MMWR CDC Surveill Summ. 1998 Apr 24;47(1):1–27. [PubMed] [Google Scholar]
  57. Millar W. J., Hill G. B. Childhood asthma. Health Rep. 1998 Winter;10(3):9–(FRE). [PubMed] [Google Scholar]
  58. Miyabara Y., Ichinose T., Takano H., Lim H. B., Sagai M. Effects of diesel exhaust on allergic airway inflammation in mice. J Allergy Clin Immunol. 1998 Nov;102(5):805–812. doi: 10.1016/s0091-6749(98)70021-1. [DOI] [PubMed] [Google Scholar]
  59. Miyabara Y., Yanagisawa R., Shimojo N., Takano H., Lim H. B., Ichinose T., Sagai M. Murine strain differences in airway inflammation caused by diesel exhaust particles. Eur Respir J. 1998 Feb;11(2):291–298. doi: 10.1183/09031936.98.11020291. [DOI] [PubMed] [Google Scholar]
  60. Mori Y., Murakami S., Sagae T., Hayashi H., Sakata M., Sagai M., Kumagai Y. Inhibition of catalase activity in vitro by diesel exhaust particles. J Toxicol Environ Health. 1996 Feb 9;47(2):125–134. doi: 10.1080/009841096161834. [DOI] [PubMed] [Google Scholar]
  61. Mosmann T. R., Cherwinski H., Bond M. W., Giedlin M. A., Coffman R. L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986 Apr 1;136(7):2348–2357. [PubMed] [Google Scholar]
  62. Muranaka M., Suzuki S., Koizumi K., Takafuji S., Miyamoto T., Ikemori R., Tokiwa H. Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice. J Allergy Clin Immunol. 1986 Apr;77(4):616–623. doi: 10.1016/0091-6749(86)90355-6. [DOI] [PubMed] [Google Scholar]
  63. Muto E., Hayashi T., Yamada K., Esaki T., Sagai M., Iguchi A. Endothelial-constitutive nitric oxide synthase exists in airways and diesel exhaust particles inhibit the effect of nitric oxide. Life Sci. 1996;59(18):1563–1570. doi: 10.1016/0024-3205(96)00487-0. [DOI] [PubMed] [Google Scholar]
  64. Nel A. E., Diaz-Sanchez D., Ng D., Hiura T., Saxon A. Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system. J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):539–554. doi: 10.1016/s0091-6749(98)70269-6. [DOI] [PubMed] [Google Scholar]
  65. Nicolai T. Environmental air pollution and lung disease in children. Monaldi Arch Chest Dis. 1999 Dec;54(6):475–478. [PubMed] [Google Scholar]
  66. Nightingale J. A., Maggs R., Cullinan P., Donnelly L. E., Rogers D. F., Kinnersley R., Chung K. F., Barnes P. J., Ashmore M., Newman-Taylor A. Airway inflammation after controlled exposure to diesel exhaust particulates. Am J Respir Crit Care Med. 2000 Jul;162(1):161–166. doi: 10.1164/ajrccm.162.1.9908092. [DOI] [PubMed] [Google Scholar]
  67. Norris G., YoungPong S. N., Koenig J. Q., Larson T. V., Sheppard L., Stout J. W. An association between fine particles and asthma emergency department visits for children in Seattle. Environ Health Perspect. 1999 Jun;107(6):489–493. doi: 10.1289/ehp.99107489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Norzila M. Z., Fakes K., Henry R. L., Simpson J., Gibson P. G. Interleukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma. Am J Respir Crit Care Med. 2000 Mar;161(3 Pt 1):769–774. doi: 10.1164/ajrccm.161.3.9809071. [DOI] [PubMed] [Google Scholar]
  69. Ohta K., Yamashita N., Tajima M., Miyasaka T., Nakano J., Nakajima M., Ishii A., Horiuchi T., Mano K., Miyamoto T. Diesel exhaust particulate induces airway hyperresponsiveness in a murine model: essential role of GM-CSF. J Allergy Clin Immunol. 1999 Nov;104(5):1024–1030. doi: 10.1016/s0091-6749(99)70084-9. [DOI] [PubMed] [Google Scholar]
  70. Ohtoshi T., Takizawa H., Okazaki H., Kawasaki S., Takeuchi N., Ohta K., Ito K. Diesel exhaust particles stimulate human airway epithelial cells to produce cytokines relevant to airway inflammation in vitro. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):778–785. doi: 10.1016/S0091-6749(98)70307-0. [DOI] [PubMed] [Google Scholar]
  71. Oosterlee A., Drijver M., Lebret E., Brunekreef B. Chronic respiratory symptoms in children and adults living along streets with high traffic density. Occup Environ Med. 1996 Apr;53(4):241–247. doi: 10.1136/oem.53.4.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Ordoñez C. L., Shaughnessy T. E., Matthay M. A., Fahy J. V. Increased neutrophil numbers and IL-8 levels in airway secretions in acute severe asthma: Clinical and biologic significance. Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1185–1190. doi: 10.1164/ajrccm.161.4.9812061. [DOI] [PubMed] [Google Scholar]
  73. Ormstad H. Suspended particulate matter in indoor air: adjuvants and allergen carriers. Toxicology. 2000 Nov 2;152(1-3):53–68. doi: 10.1016/s0300-483x(00)00292-4. [DOI] [PubMed] [Google Scholar]
  74. Passalacqua G., Ciprandi G., Canonica G. W. United airways disease: therapeutic aspects. Thorax. 2000 Oct;55 (Suppl 2):S26–S27. doi: 10.1136/thorax.55.suppl_2.S26. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Peden D. B. Development of atopy and asthma: candidate environmental influences and important periods of exposure. Environ Health Perspect. 2000 Jun;108 (Suppl 3):475–482. doi: 10.1289/ehp.00108s3475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  76. Peden D. B. Mechanisms of pollution-induced airway disease: in vivo studies. Allergy. 1997;52(38 Suppl):37–58. doi: 10.1111/j.1398-9995.1997.tb04869.x. [DOI] [PubMed] [Google Scholar]
  77. Peterson B., Saxon A. Global increases in allergic respiratory disease: the possible role of diesel exhaust particles. Ann Allergy Asthma Immunol. 1996 Oct;77(4):263–270. doi: 10.1016/S1081-1206(10)63318-2. [DOI] [PubMed] [Google Scholar]
  78. Romieu I., Meneses F., Sienra-Monge J. J., Huerta J., Ruiz Velasco S., White M. C., Etzel R. A., Hernandez-Avila M. Effects of urban air pollutants on emergency visits for childhood asthma in Mexico City. Am J Epidemiol. 1995 Mar 15;141(6):546–553. doi: 10.1093/oxfordjournals.aje.a117470. [DOI] [PubMed] [Google Scholar]
  79. Rusznak C., Devalia J. L., Davies R. J. The impact of pollution on allergic disease. Allergy. 1994;49(18 Suppl):21–27. doi: 10.1111/j.1398-9995.1994.tb04234.x. [DOI] [PubMed] [Google Scholar]
  80. Sagai M., Furuyama A., Ichinose T. Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma like symptoms in mice. Free Radic Biol Med. 1996;21(2):199–209. doi: 10.1016/0891-5849(96)00032-9. [DOI] [PubMed] [Google Scholar]
  81. Sagai M., Saito H., Ichinose T., Kodama M., Mori Y. Biological effects of diesel exhaust particles. I. In vitro production of superoxide and in vivo toxicity in mouse. Free Radic Biol Med. 1993 Jan;14(1):37–47. doi: 10.1016/0891-5849(93)90507-q. [DOI] [PubMed] [Google Scholar]
  82. Salvi S. S., Nordenhall C., Blomberg A., Rudell B., Pourazar J., Kelly F. J., Wilson S., Sandström T., Holgate S. T., Frew A. J. Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways. Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):550–557. doi: 10.1164/ajrccm.161.2.9905052. [DOI] [PubMed] [Google Scholar]
  83. Salvi S., Blomberg A., Rudell B., Kelly F., Sandström T., Holgate S. T., Frew A. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med. 1999 Mar;159(3):702–709. doi: 10.1164/ajrccm.159.3.9709083. [DOI] [PubMed] [Google Scholar]
  84. Samet J. M., Dominici F., Curriero F. C., Coursac I., Zeger S. L. Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994. N Engl J Med. 2000 Dec 14;343(24):1742–1749. doi: 10.1056/NEJM200012143432401. [DOI] [PubMed] [Google Scholar]
  85. Sampson A. P. The role of eosinophils and neutrophils in inflammation. Clin Exp Allergy. 2000 Jun;30 (Suppl 1):22–27. doi: 10.1046/j.1365-2222.2000.00092.x. [DOI] [PubMed] [Google Scholar]
  86. Schierhorn K., Zhang M., Matthias C., Kunkel G. Influence of ozone and nitrogen dioxide on histamine and interleukin formation in a human nasal mucosa culture system. Am J Respir Cell Mol Biol. 1999 May;20(5):1013–1019. doi: 10.1165/ajrcmb.20.5.3268. [DOI] [PubMed] [Google Scholar]
  87. Schwartz J., Slater D., Larson T. V., Pierson W. E., Koenig J. Q. Particulate air pollution and hospital emergency room visits for asthma in Seattle. Am Rev Respir Dis. 1993 Apr;147(4):826–831. doi: 10.1164/ajrccm/147.4.826. [DOI] [PubMed] [Google Scholar]
  88. Shirakawa T., Enomoto T., Shimazu S., Hopkin J. M. The inverse association between tuberculin responses and atopic disorder. Science. 1997 Jan 3;275(5296):77–79. doi: 10.1126/science.275.5296.77. [DOI] [PubMed] [Google Scholar]
  89. Steerenberg P. A., Dormans J. A., van Doorn C. C., Middendorp S., Vos J. G., van Loveren H. A pollen model in the rat for testing adjuvant activity of air pollution components. Inhal Toxicol. 1999 Dec;11(12):1109–1122. doi: 10.1080/089583799196619. [DOI] [PubMed] [Google Scholar]
  90. Steerenberg P. A., Dormans J. A., van Doorn C. C., Middendorp S., Vos J. G., van Loveren H. A pollen model in the rat for testing adjuvant activity of air pollution components. Inhal Toxicol. 1999 Dec;11(12):1109–1122. doi: 10.1080/089583799196619. [DOI] [PubMed] [Google Scholar]
  91. Steinsvik T. E., Ormstad H., Gaarder P. I., Aaberge I. S., Bjønness U., Løvik M. Human IgE production in hu-PBL-SCID mice injected with birch pollen and diesel exhaust particles. Toxicology. 1998 Jul 17;128(3):219–230. doi: 10.1016/s0300-483x(98)00075-4. [DOI] [PubMed] [Google Scholar]
  92. Strand V., Svartengren M., Rak S., Barck C., Bylin G. Repeated exposure to an ambient level of NO2 enhances asthmatic response to a nonsymptomatic allergen dose. Eur Respir J. 1998 Jul;12(1):6–12. doi: 10.1183/09031936.98.12010006. [DOI] [PubMed] [Google Scholar]
  93. Studnicka M., Hackl E., Pischinger J., Fangmeyer C., Haschke N., Kühr J., Urbanek R., Neumann M., Frischer T. Traffic-related NO2 and the prevalence of asthma and respiratory symptoms in seven year olds. Eur Respir J. 1997 Oct;10(10):2275–2278. doi: 10.1183/09031936.97.10102275. [DOI] [PubMed] [Google Scholar]
  94. Suzuki T., Kanoh T., Ishimori M., Ikeda S., Ohkuni H. Adjuvant activity of diesel exhaust particulates (DEP) in production of anti-IgE and anti-IgG1 antibodies to mite allergen in mice. J Clin Lab Immunol. 1996;48(5):187–199. [PubMed] [Google Scholar]
  95. Takafuji S., Suzuki S., Koizumi K., Tadokoro K., Miyamoto T., Ikemori R., Muranaka M. Diesel-exhaust particulates inoculated by the intranasal route have an adjuvant activity for IgE production in mice. J Allergy Clin Immunol. 1987 Apr;79(4):639–645. doi: 10.1016/s0091-6749(87)80161-6. [DOI] [PubMed] [Google Scholar]
  96. Takano H., Ichinose T., Miyabara Y., Shibuya T., Lim H. B., Yoshikawa T., Sagai M. Inhalation of diesel exhaust enhances allergen-related eosinophil recruitment and airway hyperresponsiveness in mice. Toxicol Appl Pharmacol. 1998 Jun;150(2):328–337. doi: 10.1006/taap.1998.8437. [DOI] [PubMed] [Google Scholar]
  97. Takano H., Ichinose T., Miyabara Y., Yoshikawa T., Sagai M. Diesel exhaust particles enhance airway responsiveness following allergen exposure in mice. Immunopharmacol Immunotoxicol. 1998 May;20(2):329–336. doi: 10.3109/08923979809038548. [DOI] [PubMed] [Google Scholar]
  98. Takano H., Lim H. B., Miyabara Y., Ichinose T., Yoshikawa T., Sagai M. Manipulation of the L-arginine-nitric oxide pathway in airway inflammation induced by diesel exhaust particles in mice. Toxicology. 1999 Nov 29;139(1-2):19–26. doi: 10.1016/s0300-483x(99)00104-3. [DOI] [PubMed] [Google Scholar]
  99. Takano H., Yoshikawa T., Ichinose T., Miyabara Y., Imaoka K., Sagai M. Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice. Am J Respir Crit Care Med. 1997 Jul;156(1):36–42. doi: 10.1164/ajrccm.156.1.9610054. [DOI] [PubMed] [Google Scholar]
  100. Takenaka H., Zhang K., Diaz-Sanchez D., Tsien A., Saxon A. Enhanced human IgE production results from exposure to the aromatic hydrocarbons from diesel exhaust: direct effects on B-cell IgE production. J Allergy Clin Immunol. 1995 Jan;95(1 Pt 1):103–115. doi: 10.1016/s0091-6749(95)70158-3. [DOI] [PubMed] [Google Scholar]
  101. Takizawa H., Ohtoshi T., Kawasaki S., Kohyama T., Desaki M., Kasama T., Kobayashi K., Nakahara K., Yamamoto K., Matsushima K. Diesel exhaust particles induce NF-kappa B activation in human bronchial epithelial cells in vitro: importance in cytokine transcription. J Immunol. 1999 Apr 15;162(8):4705–4711. [PubMed] [Google Scholar]
  102. Terada N., Hamano N., Maesako K. I., Hiruma K., Hohki G., Suzuki K., Ishikawa K., Konno A. Diesel exhaust particulates upregulate histamine receptor mRNA and increase histamine-induced IL-8 and GM-CSF production in nasal epithelial cells and endothelial cells. Clin Exp Allergy. 1999 Jan;29(1):52–59. doi: 10.1046/j.1365-2222.1999.00406.x. [DOI] [PubMed] [Google Scholar]
  103. Terada N., Maesako K., Hiruma K., Hamano N., Houki G., Konno A., Ikeda T., Sai M. Diesel exhaust particulates enhance eosinophil adhesion to nasal epithelial cells and cause degranulation. Int Arch Allergy Immunol. 1997 Oct;114(2):167–174. doi: 10.1159/000237663. [DOI] [PubMed] [Google Scholar]
  104. Trenga C. A., Koenig J. Q., Williams P. V. Sulphur dioxide sensitivity and plasma antioxidants in adult subjects with asthma. Occup Environ Med. 1999 Aug;56(8):544–547. doi: 10.1136/oem.56.8.544. [DOI] [PMC free article] [PubMed] [Google Scholar]
  105. Tsien A., Diaz-Sanchez D., Ma J., Saxon A. The organic component of diesel exhaust particles and phenanthrene, a major polyaromatic hydrocarbon constituent, enhances IgE production by IgE-secreting EBV-transformed human B cells in vitro. Toxicol Appl Pharmacol. 1997 Feb;142(2):256–263. doi: 10.1006/taap.1996.8063. [DOI] [PubMed] [Google Scholar]
  106. Van Niekerk C. H., Weinberg E. G., Shore S. C., Heese H. V., Van Schalkwyk J. Prevalence of asthma: a comparative study of urban and rural Xhosa children. Clin Allergy. 1979 Jul;9(4):319–314. doi: 10.1111/j.1365-2222.1979.tb02489.x. [DOI] [PubMed] [Google Scholar]
  107. Wade J. F., 3rd, Newman L. S. Diesel asthma. Reactive airways disease following overexposure to locomotive exhaust. J Occup Med. 1993 Feb;35(2):149–154. [PubMed] [Google Scholar]
  108. Wang M., Saxon A., Diaz-Sanchez D. Early IL-4 production driving Th2 differentiation in a human in vivo allergic model is mast cell derived. Clin Immunol. 1999 Jan;90(1):47–54. doi: 10.1006/clim.1998.4628. [DOI] [PubMed] [Google Scholar]
  109. Weiss K. B., Sullivan S. D., Lyttle C. S. Trends in the cost of illness for asthma in the United States, 1985-1994. J Allergy Clin Immunol. 2000 Sep;106(3):493–499. doi: 10.1067/mai.2000.109426. [DOI] [PubMed] [Google Scholar]
  110. Yang H. M., Barger M. W., Castranova V., Ma J. K., Yang J. J., Ma J. Y. Effects of diesel exhaust particles (DEP), carbon black, and silica on macrophage responses to lipopolysaccharide: evidence of DEP suppression of macrophage activity. J Toxicol Environ Health A. 1999 Nov 12;58(5):261–278. doi: 10.1080/009841099157232. [DOI] [PubMed] [Google Scholar]
  111. Yoshino S., Sagai M. Induction of systemic Th1 and Th2 immune responses by oral administration of soluble antigen and diesel exhaust particles. Cell Immunol. 1999 Feb 25;192(1):72–78. doi: 10.1006/cimm.1998.1427. [DOI] [PubMed] [Google Scholar]
  112. von Mutius E. The environmental predictors of allergic disease. J Allergy Clin Immunol. 2000 Jan;105(1 Pt 1):9–19. doi: 10.1016/s0091-6749(00)90171-4. [DOI] [PubMed] [Google Scholar]

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