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. 2002 Dec;110(Suppl 6):1037–1040. doi: 10.1289/ehp.02110s61037

Introduction--the methyl parathion story: a chronicle of misuse and preventable human exposure.

Carol Rubin 1, Emilio Esteban 1, Robert H Hill Jr 1, Ken Pearce 1
PMCID: PMC1241289  PMID: 12634136

Abstract

In the fall of 1994, Lorain County, Ohio, became the site of the first investigation of several large-scale incidences in which the organophosphate pesticide methyl parathion was illegally applied to private residences. The extent of potential human exposure to this pesticide led the Ohio Department of Health to formally request technical assistance from the Centers for Disease Control and Prevention (CDC). This article describes the initial investigation of 64 homes in Ohio and introduces the method of using both biological markers of exposure (p-nitrophenol levels in human urine samples) and environmental markers of contamination in dust and air samples when making public health decisions about the cleanup of homes sprayed with methyl parathion. The results of the CDC rapid investigation led the U.S. Environmental Protection Agency to declare the contaminated homes in Lorain County a Superfund cleanup site. Seven years after the Lorain incident, and after subsequent Superfund actions had been implemented in Illinois and Mississippi, researchers participated in an expanded session devoted to methyl parathion at the 11th Annual Meeting of the International Society of Exposure Analysis held in Charleston, South Carolina, in the fall of 2001. The articles included in this monograph are based on presentations at that meeting. They report previously unpublished data that tell the methyl parathion story from different perspectives, each providing in-depth information about separate aspects of this multistate, multiagency, and multimillion dollar chemical exposure. This monograph is the methyl parathion story.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barr Dana B., Turner Wayman E., DiPietro Emily, McClure P. Cheryl, Baker Samuel E., Barr John R., Gehle Kimberly, Grissom Raymond E., Jr, Bravo Roberto, Driskell W. Jack. Measurement of p-nitrophenol in the urine of residents whose homes were contaminated with methyl parathion. Environ Health Perspect. 2002 Dec;110 (Suppl 6):1085–1091. doi: 10.1289/ehp.02110s61085. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Clark J. Milton, Bing-Canar John, Renninger Steve, Dollhopf Ralph, El-Zein Jason, Star Dave, Zimmerman Dea, Anisuzzaman Abul, Boylan Kathline, Tomaszewski Terrence. Methyl parathion in residential properties: relocation and decontamination methodology. Environ Health Perspect. 2002 Dec;110 (Suppl 6):1061–1070. doi: 10.1289/ehp.02110s61061. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Esteban E., Rubin C., Hill R., Olson D., Pearce K. Association between indoor residential contamination with methyl parathion and urinary para-nitrophenol. J Expo Anal Environ Epidemiol. 1996 Jul-Sep;6(3):375–387. [PubMed] [Google Scholar]
  4. FAZEKAS I. G., RENGEI B. HAL'ALOS "WOFATOX"-M'ERGEZ'ES. Orv Hetil. 1964 Dec 6;105:2335–2336. [PubMed] [Google Scholar]
  5. Hill R. H., Jr, Shealy D. B., Head S. L., Williams C. C., Bailey S. L., Gregg M., Baker S. E., Needham L. L. Determination of pesticide metabolites in human urine using an isotope dilution technique and tandem mass spectrometry. J Anal Toxicol. 1995 Sep;19(5):323–329. doi: 10.1093/jat/19.5.323. [DOI] [PubMed] [Google Scholar]
  6. Hill Robert H., Jr, Head Susan, Barr Dana B., Rubin Carol, Esteban Emilio, Baker Samuel E., Bailey Sandra, Needham Larry L. Public health decisions: the laboratory's role in the Lorain County, Ohio, investigation. Environ Health Perspect. 2002 Dec;110 (Suppl 6):1057–1059. doi: 10.1289/ehp.02110s61057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hryhorczuk Daniel O., Moomey Mike, Burton Ann, Runkle Ken, Chen Edwin, Saxer Tiffanie, Slightom Jennifer, Dimos John, McCann Ken, Barr Dana. Urinary p-nitrophenol as a biomarker of household exposure to methyl parathion. Environ Health Perspect. 2002 Dec;110 (Suppl 6):1041–1046. doi: 10.1289/ehp.02110s61041. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Imtiaz Rubina, Haugh Gilbert. Analysis of environmental and biologic methyl parathion data to improve future data collection. Environ Health Perspect. 2002 Dec;110 (Suppl 6):1071–1074. doi: 10.1289/ehp.02110s61071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kahn E. Pesticide related illness in California farm workers. J Occup Med. 1976 Oct;18(10):693–696. doi: 10.1097/00043764-197610000-00013. [DOI] [PubMed] [Google Scholar]
  10. Rubin Carol, Esteban Emilio, Kieszak Stephanie, Hill Robert H., Jr, Dunlop Boadie, Yacovac Rebecca, Trottier Janine, Boylan Kathy, Tomasewski Terri, Pearce Ken. Assessment of human exposure and human health effects after indoor application of methyl parathion in Lorain County, Ohio, 1995-1996. Environ Health Perspect. 2002 Dec;110 (Suppl 6):1047–1051. doi: 10.1289/ehp.02110s61047. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Wasley Annemarie, Lepine Lisa A., Jenkins Roland, Rubin Carol. An investigation of unexplained infant deaths in houses contaminated with methyl parathion. Environ Health Perspect. 2002 Dec;110 (Suppl 6):1053–1056. doi: 10.1289/ehp.02110s61053. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Zeitz Perri, Kakolewski Kirsten, Imtiaz Rubina, Kaye Wendy. Methods of assessing neurobehavioral development in children exposed to methyl parathion in Mississippi and Ohio. Environ Health Perspect. 2002 Dec;110 (Suppl 6):1079–1083. doi: 10.1289/ehp.02110s61079. [DOI] [PMC free article] [PubMed] [Google Scholar]

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