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. 2003 Jan;111(1):1–12. doi: 10.1289/ehp.111-1241299

Priorities for development of research methods in occupational cancer.

Elizabeth M Ward 1, Paul A Schulte 1, Steve Bayard 1, Aaron Blair 1, Paul Brandt-Rauf 1, Mary Ann Butler 1, David Dankovic 1, Ann F Hubbs 1, Carol Jones 1, Myra Karstadt 1, Gregory L Kedderis 1, Ronald Melnick 1, Carrie A Redlich 1, Nathaniel Rothman 1, Russell E Savage 1, Michael Sprinker 1, Mark Toraason 1, Ainsley Weston 1, Andrew F Olshan 1, Patricia Stewart 1, Sheila Hoar Zahm 1; National Occupational Research Agenda Team1
PMCID: PMC1241299  PMID: 12524210

Abstract

Occupational cancer research methods was identified in 1996 as 1 of 21 priority research areas in the National Occupational Research Agenda (NORA). To implement NORA, teams of experts from various sectors were formed and given the charge to further define research needs and develop strategies to enhance or augment research in each priority area. This article is a product of that process. Focus on occupational cancer research methods is important both because occupational factors play a significant role in a number of cancers, resulting in significant morbidity and mortality, and also because occupational cohorts (because of higher exposure levels) often provide unique opportunities to evaluate health effects of environmental toxicants and understand the carcinogenic process in humans. Despite an explosion of new methods for cancer research in general, these have not been widely applied to occupational cancer research. In this article we identify needs and gaps in occupational cancer research methods in four broad areas: identification of occupational carcinogens, design of epidemiologic studies, risk assessment, and primary and secondary prevention. Progress in occupational cancer will require interdisciplinary research involving epidemiologists, industrial hygienists, toxicologists, and molecular biologists.

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Selected References

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