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. 2003 Mar;111(3):349–355. doi: 10.1289/ehp.5456

Organochlorines in Swedish women: determinants of serum concentrations.

Anders Wicklund Glynn 1, Fredrik Granath 1, Marie Aune 1, Samuel Atuma 1, Per Ola Darnerud 1, Rickard Bjerselius 1, Harri Vainio 1, Elisabete Weiderpass 1
PMCID: PMC1241393  PMID: 12611665

Abstract

We studied associations between lifestyle/medical factors and lipid-adjusted serum concentrations of seven polychlorinated biphenyl (PCB) congeners and five chlorinated pesticides/metabolites among 205 Swedish women (54-75 years old). Serum concentrations were significantly associated with age, body mass index, body weight change, diabetes mellitus, consumption of fatty fish, and place of residence. The findings suggest that lifestyle/medical factors may confound results in epidemiologic studies when they are related to both serum concentrations and disease. Moreover, disease itself may influence serum concentrations of some organochlorines, as indicated by the negative associations between recent weight change and serum concentrations of some PCB congeners, p,p -dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) and the positive association between diabetes mellitus and HCB concentrations. Age was the only determinant that showed a consistent association with all compounds studied (positive); otherwise associations with single determinants varied among compounds even within the PCB group. This shows that the studied organochlorines should not be treated as a homogeneous group of compounds in epidemiologic studies.

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Selected References

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  1. Ahlborg U. G., Lipworth L., Titus-Ernstoff L., Hsieh C. C., Hanberg A., Baron J., Trichopoulos D., Adami H. O. Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: an assessment of the biological and epidemiological evidence. Crit Rev Toxicol. 1995;25(6):463–531. doi: 10.3109/10408449509017924. [DOI] [PubMed] [Google Scholar]
  2. Asplund L., Svensson B. G., Nilsson A., Eriksson U., Jansson B., Jensen S., Wideqvist U., Skerfving S. Polychlorinated biphenyls, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (p,p'-DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) in human plasma related to fish consumption. Arch Environ Health. 1994 Nov-Dec;49(6):477–486. doi: 10.1080/00039896.1994.9955004. [DOI] [PubMed] [Google Scholar]
  3. Atuma S. S., Aune M. Method for the determination of PCB congeners and chlorinated pesticides in human blood serum. Bull Environ Contam Toxicol. 1999 Jan;62(1):8–15. doi: 10.1007/s001289900834. [DOI] [PubMed] [Google Scholar]
  4. Atuma S. S., Linder C. E., Wicklund-Glynn A., Andersson O., Larsson L. Survey of consumption fish from Swedish waters for chlorinated pesticides and polychlorinated biphenyls. Chemosphere. 1996 Sep;33(5):791–799. doi: 10.1016/0045-6535(96)00235-4. [DOI] [PubMed] [Google Scholar]
  5. Atuma S., Bergh A., Hansson L., Wicklund-Glynn A., Johnsson H. Non-ortho PCB levels in various fish species from the east and west coast of Sweden. Chemosphere. 1998 Oct-Nov;37(9-12):2451–2457. doi: 10.1016/s0045-6535(98)00301-4. [DOI] [PubMed] [Google Scholar]
  6. Brouwer A., Ahlborg U. G., Van den Berg M., Birnbaum L. S., Boersma E. R., Bosveld B., Denison M. S., Gray L. E., Hagmar L., Holene E. Functional aspects of developmental toxicity of polyhalogenated aromatic hydrocarbons in experimental animals and human infants. Eur J Pharmacol. 1995 May 26;293(1):1–40. doi: 10.1016/0926-6917(95)90015-2. [DOI] [PubMed] [Google Scholar]
  7. Chevrier J., Dewailly E., Ayotte P., Mauriège P., Després J. P., Tremblay A. Body weight loss increases plasma and adipose tissue concentrations of potentially toxic pollutants in obese individuals. Int J Obes Relat Metab Disord. 2000 Oct;24(10):1272–1278. doi: 10.1038/sj.ijo.0801380. [DOI] [PubMed] [Google Scholar]
  8. Cranmer M., Louie S., Kennedy R. H., Kern P. A., Fonseca V. A. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with hyperinsulinemia and insulin resistance. Toxicol Sci. 2000 Aug;56(2):431–436. doi: 10.1093/toxsci/56.2.431. [DOI] [PubMed] [Google Scholar]
  9. DeVoto E., Fiore B. J., Millikan R., Anderson H. A., Sheldon L., Sonzogni W. C., Longnecker M. P. Correlations among human blood levels of specific PCB congeners and implications for epidemiologic studies. Am J Ind Med. 1997 Dec;32(6):606–613. doi: 10.1002/(sici)1097-0274(199712)32:6<606::aid-ajim6>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  10. DeVoto E., Kohlmeier L., Heeschen W. Some dietary predictors of plasma organochlorine concentrations in an elderly German population. Arch Environ Health. 1998 Mar-Apr;53(2):147–155. doi: 10.1080/00039896.1998.10545976. [DOI] [PubMed] [Google Scholar]
  11. Deutch B., Hansen J. C. High human plasma levels of organochlorine compounds in Greenland. Regional differences and lifestyle effects. Dan Med Bull. 2000 Apr;47(2):132–137. [PubMed] [Google Scholar]
  12. Dorgan J. F., Brock J. W., Rothman N., Needham L. L., Miller R., Stephenson H. E., Jr, Schussler N., Taylor P. R. Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis (USA). Cancer Causes Control. 1999 Feb;10(1):1–11. doi: 10.1023/a:1008824131727. [DOI] [PubMed] [Google Scholar]
  13. Gladen B. C., Longnecker M. P., Schecter A. J. Correlations among polychlorinated biphenyls, dioxins, and furans in humans. Am J Ind Med. 1999 Jan;35(1):15–20. doi: 10.1002/(sici)1097-0274(199901)35:1<15::aid-ajim3>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  14. Glynn A. W., Atuma S., Aune M., Darnerud P. O., Cnattingius S. Polychlorinated biphenyl congeners as markers of toxic equivalents of polychlorinated biphenyls, dibenzo-p-dioxins and dibenzofurans in breast milk. Environ Res. 2001 Jul;86(3):217–228. doi: 10.1006/enrs.2001.4270. [DOI] [PubMed] [Google Scholar]
  15. Glynn A. W., Wernroth L., Atuma S., Linder C. E., Aune M., Nilsson I., Darnerud P. O. PCB and chlorinated pesticide concentrations in swine and bovine adipose tissue in Sweden 1991-1997: spatial and temporal trends. Sci Total Environ. 2000 Feb 10;246(2-3):195–206. doi: 10.1016/s0048-9697(99)00458-1. [DOI] [PubMed] [Google Scholar]
  16. Grimvall E., Rylander L., Nilsson-Ehle P., Nilsson U., Strömberg U., Hagmar L., Ostman C. Monitoring of polychlorinated biphenyls in human blood plasma: methodological developments and influence of age, lactation, and fish consumption. Arch Environ Contam Toxicol. 1997 Apr;32(3):329–336. doi: 10.1007/s002449900193. [DOI] [PubMed] [Google Scholar]
  17. Hagmar L., Rylander L., Dyremark E., Klasson-Wehler E., Erfurth E. M. Plasma concentrations of persistent organochlorines in relation to thyrotropin and thyroid hormone levels in women. Int Arch Occup Environ Health. 2001 Apr;74(3):184–188. doi: 10.1007/s004200000213. [DOI] [PubMed] [Google Scholar]
  18. Hunter D. J., Hankinson S. E., Laden F., Colditz G. A., Manson J. E., Willett W. C., Speizer F. E., Wolff M. S. Plasma organochlorine levels and the risk of breast cancer. N Engl J Med. 1997 Oct 30;337(18):1253–1258. doi: 10.1056/NEJM199710303371801. [DOI] [PubMed] [Google Scholar]
  19. Høyer A. P., Jørgensen T., Grandjean P., Hartvig H. B. Repeated measurements of organochlorine exposure and breast cancer risk (Denmark). Cancer Causes Control. 2000 Feb;11(2):177–184. doi: 10.1023/a:1008926219539. [DOI] [PubMed] [Google Scholar]
  20. Imbeault P., Chevrier J., Dewailly E., Ayotte P., Després J. P., Tremblay A., Mauriège P. Increase in plasma pollutant levels in response to weight loss in humans is related to in vitro subcutaneous adipocyte basal lipolysis. Int J Obes Relat Metab Disord. 2001 Nov;25(11):1585–1591. doi: 10.1038/sj.ijo.0801817. [DOI] [PubMed] [Google Scholar]
  21. Inmaculada Sanz-Gallardo M., Guallar E., van Tveer P., Longnecker M. P., Strain J. J., Martin B. C., Kardinaal A. F., Fernández-Crehuet J., Thamm M., Kohlmeier L. Determinants of p,p-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities. Arch Environ Health. 1999 Jul-Aug;54(4):277–283. doi: 10.1080/00039899909602486. [DOI] [PubMed] [Google Scholar]
  22. Jacobson J. L., Jacobson S. W. Evidence for PCBs as neurodevelopmental toxicants in humans. Neurotoxicology. 1997;18(2):415–424. [PubMed] [Google Scholar]
  23. Kodama H., Ota H. Transfer of polychlorinated biphenyls to infants from their mothers. Arch Environ Health. 1980 Mar-Apr;35(2):95–100. [PubMed] [Google Scholar]
  24. Koopman-Esseboom C., Morse D. C., Weisglas-Kuperus N., Lutkeschipholt I. J., Van der Paauw C. G., Tuinstra L. G., Brouwer A., Sauer P. J. Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants. Pediatr Res. 1994 Oct;36(4):468–473. doi: 10.1203/00006450-199410000-00009. [DOI] [PubMed] [Google Scholar]
  25. Lackmann G. M., Angerer J., Töllner U. Parental smoking and neonatal serum levels of polychlorinated biphenyls and hexachlorobenzene. Pediatr Res. 2000 May;47(5):598–601. doi: 10.1203/00006450-200005000-00007. [DOI] [PubMed] [Google Scholar]
  26. Laden F., Collman G., Iwamoto K., Alberg A. J., Berkowitz G. S., Freudenheim J. L., Hankinson S. E., Helzlsouer K. J., Holford T. R., Huang H. Y. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene and polychlorinated biphenyls and breast cancer: combined analysis of five U.S. studies. J Natl Cancer Inst. 2001 May 16;93(10):768–776. doi: 10.1093/jnci/93.10.768. [DOI] [PubMed] [Google Scholar]
  27. Laden F., Neas L. M., Spiegelman D., Hankinson S. E., Willett W. C., Ireland K., Wolff M. S., Hunter D. J. Predictors of plasma concentrations of DDE and PCBs in a group of U.S. women. Environ Health Perspect. 1999 Jan;107(1):75–81. doi: 10.1289/ehp.9910775. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Longnecker M. P., Klebanoff M. A., Brock J. W., Zhou H., Collaborative Perinatal Project (CPP) Polychlorinated biphenyl serum levels in pregnant subjects with diabetes. Diabetes Care. 2001 Jun;24(6):1099–1101. doi: 10.2337/diacare.24.6.1099. [DOI] [PubMed] [Google Scholar]
  29. Phillips D. L., Pirkle J. L., Burse V. W., Bernert J. T., Jr, Henderson L. O., Needham L. L. Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding. Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):495–500. doi: 10.1007/BF01055015. [DOI] [PubMed] [Google Scholar]
  30. Ribas-Fitó N., Sala M., Kogevinas M., Sunyer J. Polychlorinated biphenyls (PCBs) and neurological development in children: a systematic review. J Epidemiol Community Health. 2001 Aug;55(8):537–546. doi: 10.1136/jech.55.8.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Romieu I., Hernandez-Avila M., Lazcano-Ponce E., Weber J. P., Dewailly E. Breast cancer, lactation history, and serum organochlorines. Am J Epidemiol. 2000 Aug 15;152(4):363–370. doi: 10.1093/aje/152.4.363. [DOI] [PubMed] [Google Scholar]
  32. Rylander L., Dyremark E., Strömberg U., Ostman C., Hagmar L. The impact of age, lactation and dietary habits on PCB in plasma in Swedish women. Sci Total Environ. 1997 Nov 14;207(1):55–61. doi: 10.1016/s0048-9697(97)00245-3. [DOI] [PubMed] [Google Scholar]
  33. Rylander L., Strömberg U., Hagmar L. Agreement between reported fish consumption obtained by two interviews and its impact on the results in a reproduction study. Eur J Epidemiol. 1998 Jan;14(1):93–97. doi: 10.1023/a:1007488117066. [DOI] [PubMed] [Google Scholar]
  34. Schildkraut J. M., Demark-Wahnefried W., DeVoto E., Hughes C., Laseter J. L., Newman B. Environmental contaminants and body fat distribution. Cancer Epidemiol Biomarkers Prev. 1999 Feb;8(2):179–183. [PubMed] [Google Scholar]
  35. Schmid K., Lederer P., Göen T., Schaller K. H., Strebl H., Weber A., Angerer J., Lehnert G. Internal exposure to hazardous substances of persons from various continents: investigations on exposure to different organochlorine compounds. Int Arch Occup Environ Health. 1997;69(6):399–406. doi: 10.1007/s004200050167. [DOI] [PubMed] [Google Scholar]
  36. Snedeker S. M. Pesticides and breast cancer risk: a review of DDT, DDE, and dieldrin. Environ Health Perspect. 2001 Mar;109 (Suppl 1):35–47. doi: 10.1289/ehp.01109s135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Steenland K., Calvert G., Ketchum N., Michalek J. Dioxin and diabetes mellitus: an analysis of the combined NIOSH and Ranch Hand data. Occup Environ Med. 2001 Oct;58(10):641–648. doi: 10.1136/oem.58.10.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Van den Berg M., Birnbaum L., Bosveld A. T., Brunström B., Cook P., Feeley M., Giesy J. P., Hanberg A., Hasegawa R., Kennedy S. W. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect. 1998 Dec;106(12):775–792. doi: 10.1289/ehp.98106775. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Walford R. L., Mock D., MacCallum T., Laseter J. L. Physiologic changes in humans subjected to severe, selective calorie restriction for two years in biosphere 2: health, aging, and toxicological perspectives. Toxicol Sci. 1999 Dec;52(2 Suppl):61–65. [PubMed] [Google Scholar]
  40. Weiderpass E., Adami H. O., Baron J. A., Wicklund-Glynn A., Aune M., Atuma S., Persson I. Organochlorines and endometrial cancer risk. Cancer Epidemiol Biomarkers Prev. 2000 May;9(5):487–493. [PubMed] [Google Scholar]
  41. Weisglas-Kuperus N., Patandin S., Berbers G. A., Sas T. C., Mulder P. G., Sauer P. J., Hooijkaas H. Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ Health Perspect. 2000 Dec;108(12):1203–1207. doi: 10.1289/ehp.001081203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Wolff M. S., Berkowitz G. S., Brower S., Senie R., Bleiweiss I. J., Tartter P., Pace B., Roy N., Wallenstein S., Weston A. Organochlorine exposures and breast cancer risk in New York City women. Environ Res. 2000 Oct;84(2):151–161. doi: 10.1006/enrs.2000.4075. [DOI] [PubMed] [Google Scholar]
  43. Wolff M. S., Zeleniuch-Jacquotte A., Dubin N., Toniolo P. Risk of breast cancer and organochlorine exposure. Cancer Epidemiol Biomarkers Prev. 2000 Mar;9(3):271–277. [PubMed] [Google Scholar]

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