Abstract
Increasing recognition that children may be more susceptible than adults to environmental exposures and that they experience potentially life-long consequences of such exposures has led to widespread support for a large new cohort study in the United States. In this article, we propose a framework for a new cohort study of children, with follow-up beginning before birth and continuing to age 21 years. We also describe the administrative structure that has been built to develop the proposal further. The structure includes a partnership between federal and nonfederal scientists and relies on a collaborative, interdisciplinary research effort of unprecedented scale in medical research. We discuss briefly how the proposed cohort could be used to examine, among many other things, the effect of chemical contaminants in breast milk on children's health and development.
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- Aberg A., Westbom L., Källén B. Congenital malformations among infants whose mothers had gestational diabetes or preexisting diabetes. Early Hum Dev. 2001 Mar;61(2):85–95. doi: 10.1016/s0378-3782(00)00125-0. [DOI] [PubMed] [Google Scholar]
- Becerra J. E., Khoury M. J., Cordero J. F., Erickson J. D. Diabetes mellitus during pregnancy and the risks for specific birth defects: a population-based case-control study. Pediatrics. 1990 Jan;85(1):1–9. [PubMed] [Google Scholar]
- Berenson G. S. Bogalusa Heart Study: a long-term community study of a rural biracial (black/white) population. Am J Med Sci. 2001 Nov;322(5):267–274. [PubMed] [Google Scholar]
- Bhandari Mohit, Lochner Heather, Tornetta Paul., 3rd Effect of continuous versus dichotomous outcome variables on study power when sample sizes of orthopaedic randomized trials are small. Arch Orthop Trauma Surg. 2001 Sep 11;122(2):96–98. doi: 10.1007/s004020100347. [DOI] [PubMed] [Google Scholar]
- Bresnahan M. A., Brown A. S., Schaefer C. A., Begg M. D., Wyatt R. J., Susser E. S. Incidence and cumulative risk of treated schizophrenia in the prenatal determinants of schizophrenia study. Schizophr Bull. 2000;26(2):297–308. doi: 10.1093/oxfordjournals.schbul.a033454. [DOI] [PubMed] [Google Scholar]
- Brouwer A., Ahlborg U. G., van Leeuwen F. X., Feeley M. M. Report of the WHO working group on the assessment of health risks for human infants from exposure to PCDDs, PCDFs and PCBs. Chemosphere. 1998 Oct-Nov;37(9-12):1627–1643. doi: 10.1016/s0045-6535(98)00230-6. [DOI] [PubMed] [Google Scholar]
- Choi J., Cooper K. L., Hensle T. W., Fisch H. Incidence and surgical repair rates of hypospadias in New York state. Urology. 2001 Jan;57(1):151–153. doi: 10.1016/s0090-4295(00)00848-7. [DOI] [PubMed] [Google Scholar]
- Colditz G. A., Manson J. E., Hankinson S. E. The Nurses' Health Study: 20-year contribution to the understanding of health among women. J Womens Health. 1997 Feb;6(1):49–62. doi: 10.1089/jwh.1997.6.49. [DOI] [PubMed] [Google Scholar]
- Collins F. S., McKusick V. A. Implications of the Human Genome Project for medical science. JAMA. 2001 Feb 7;285(5):540–544. doi: 10.1001/jama.285.5.540. [DOI] [PubMed] [Google Scholar]
- Couture-Haws L., Harris M. W., McDonald M. M., Lockhart A. C., Birnbaum L. S. Hydronephrosis in mice exposed to TCDD-contaminated breast milk: identification of the peak period of sensitivity and assessment of potential recovery. Toxicol Appl Pharmacol. 1991 Mar 1;107(3):413–428. doi: 10.1016/0041-008x(91)90305-x. [DOI] [PubMed] [Google Scholar]
- Eskenazi B., Bradman A., Castorina R. Exposures of children to organophosphate pesticides and their potential adverse health effects. Environ Health Perspect. 1999 Jun;107 (Suppl 3):409–419. doi: 10.1289/ehp.99107s3409. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fagot-Campagna A., Pettitt D. J., Engelgau M. M., Burrows N. R., Geiss L. S., Valdez R., Beckles G. L., Saaddine J., Gregg E. W., Williamson D. F. Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr. 2000 May;136(5):664–672. doi: 10.1067/mpd.2000.105141. [DOI] [PubMed] [Google Scholar]
- Feuchtbaum L. B., Currier R. J., Riggle S., Roberson M., Lorey F. W., Cunningham G. C. Neural tube defect prevalence in California (1990-1994): eliciting patterns by type of defect and maternal race/ethnicity. Genet Test. 1999;3(3):265–272. doi: 10.1089/109065799316572. [DOI] [PubMed] [Google Scholar]
- Freeman N. C., Sheldon L., Jimenez M., Melnyk L., Pellizzari E., Berry M. Contribution of children's activities to lead contamination of food. J Expo Anal Environ Epidemiol. 2001 Sep-Oct;11(5):407–413. doi: 10.1038/sj.jea.7500183. [DOI] [PubMed] [Google Scholar]
- Golding J., Pembrey M., Jones R., ALSPAC Study Team ALSPAC--the Avon Longitudinal Study of Parents and Children. I. Study methodology. Paediatr Perinat Epidemiol. 2001 Jan;15(1):74–87. doi: 10.1046/j.1365-3016.2001.00325.x. [DOI] [PubMed] [Google Scholar]
- Golding J. Unnatural constituents of breast milk--medication, lifestyle, pollutants, viruses. Early Hum Dev. 1997 Oct 29;49 (Suppl):S29–S43. doi: 10.1016/s0378-3782(97)00052-2. [DOI] [PubMed] [Google Scholar]
- Guerrero J. L., Thurman D. J., Sniezek J. E. Emergency department visits associated with traumatic brain injury: United States, 1995-1996. Brain Inj. 2000 Feb;14(2):181–186. [PubMed] [Google Scholar]
- Hoffman Julien I. E., Kaplan Samuel. The incidence of congenital heart disease. J Am Coll Cardiol. 2002 Jun 19;39(12):1890–1900. doi: 10.1016/s0735-1097(02)01886-7. [DOI] [PubMed] [Google Scholar]
- Hooper K., McDonald T. A. The PBDEs: an emerging environmental challenge and another reason for breast-milk monitoring programs. Environ Health Perspect. 2000 May;108(5):387–392. doi: 10.1289/ehp.00108387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jensen A. A. Chemical contaminants in human milk. Residue Rev. 1983;89:1–128. doi: 10.1007/978-1-4612-5601-4_1. [DOI] [PubMed] [Google Scholar]
- Jones K. L., Smith D. W., Streissguth A. P., Myrianthopoulos N. C. Outcome in offspring of chronic alcoholic women. Lancet. 1974 Jun 1;1(7866):1076–1078. doi: 10.1016/s0140-6736(74)90555-8. [DOI] [PubMed] [Google Scholar]
- Karmaus W., DeKoning E. P., Kruse H., Witten J., Osius N. Early childhood determinants of organochlorine concentrations in school-aged children. Pediatr Res. 2001 Sep;50(3):331–336. doi: 10.1203/00006450-200109000-00007. [DOI] [PubMed] [Google Scholar]
- Karmaus Wilfried, Asakevich Scott, Indurkhya Alka, Witten Jutta, Kruse Hermann. Childhood growth and exposure to dichlorodiphenyl dichloroethene and polychlorinated biphenyls. J Pediatr. 2002 Jan;140(1):33–39. doi: 10.1067/mpd.2002.120764. [DOI] [PubMed] [Google Scholar]
- Klonoff-Cohen H. S., Edelstein S. L., Lefkowitz E. S., Srinivasan I. P., Kaegi D., Chang J. C., Wiley K. J. The effect of passive smoking and tobacco exposure through breast milk on sudden infant death syndrome. JAMA. 1995 Mar 8;273(10):795–798. doi: 10.1001/jama.1995.03520340051035. [DOI] [PubMed] [Google Scholar]
- Kuban K. C., Leviton A. Cerebral palsy. N Engl J Med. 1994 Jan 20;330(3):188–195. doi: 10.1056/NEJM199401203300308. [DOI] [PubMed] [Google Scholar]
- Lanphear B. P., Dietrich K., Auinger P., Cox C. Cognitive deficits associated with blood lead concentrations <10 microg/dL in US children and adolescents. Public Health Rep. 2000 Nov-Dec;115(6):521–529. doi: 10.1093/phr/115.6.521. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Little R. E., Anderson K. W., Ervin C. H., Worthington-Roberts B., Clarren S. K. Maternal alcohol use during breast-feeding and infant mental and motor development at one year. N Engl J Med. 1989 Aug 17;321(7):425–430. doi: 10.1056/NEJM198908173210703. [DOI] [PubMed] [Google Scholar]
- Lucas A., Fewtrell M. S., Cole T. J. Fetal origins of adult disease-the hypothesis revisited. BMJ. 1999 Jul 24;319(7204):245–249. doi: 10.1136/bmj.319.7204.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mannino David M., Homa David M., Akinbami Lara J., Moorman Jeanne E., Gwynn Charon, Redd Stephen C. Surveillance for asthma--United States, 1980-1999. MMWR Surveill Summ. 2002 Mar 29;51(1):1–13. [PubMed] [Google Scholar]
- Marshall W. W., Haley R. W. Use of a secure Internet Web site for collaborative medical research. JAMA. 2000 Oct 11;284(14):1843–1849. doi: 10.1001/jama.284.14.1843. [DOI] [PubMed] [Google Scholar]
- Martinez Fernando D. Development of wheezing disorders and asthma in preschool children. Pediatrics. 2002 Feb;109(2 Suppl):362–367. [PubMed] [Google Scholar]
- Naeye R. L., Ladis B., Drage J. S. Sudden infant death syndrome. A prospective study. Am J Dis Child. 1976 Nov;130(11):1207–1210. doi: 10.1001/archpedi.1976.02120120041005. [DOI] [PubMed] [Google Scholar]
- Nelson K. B., Ellenberg J. H. Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med. 1976 Nov 4;295(19):1029–1033. doi: 10.1056/NEJM197611042951901. [DOI] [PubMed] [Google Scholar]
- Nelson Karin B., Willoughby Rodney E. Overview: infection during pregnancy and neurologic outcome in the child. Ment Retard Dev Disabil Res Rev. 2002;8(1):1–2. doi: 10.1002/mrdd.10010. [DOI] [PubMed] [Google Scholar]
- Olsen J., Melbye M., Olsen S. F., Sørensen T. I., Aaby P., Andersen A. M., Taxbøl D., Hansen K. D., Juhl M., Schow T. B. The Danish National Birth Cohort--its background, structure and aim. Scand J Public Health. 2001 Dec;29(4):300–307. doi: 10.1177/14034948010290040201. [DOI] [PubMed] [Google Scholar]
- Onkamo P., Vänänen S., Karvonen M., Tuomilehto J. Worldwide increase in incidence of Type I diabetes--the analysis of the data on published incidence trends. Diabetologia. 1999 Dec;42(12):1395–1403. doi: 10.1007/s001250051309. [DOI] [PubMed] [Google Scholar]
- Osius N., Karmaus W., Kruse H., Witten J. Exposure to polychlorinated biphenyls and levels of thyroid hormones in children. Environ Health Perspect. 1999 Oct;107(10):843–849. doi: 10.1289/ehp.99107843. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Paulozzi L. J. International trends in rates of hypospadias and cryptorchidism. Environ Health Perspect. 1999 Apr;107(4):297–302. doi: 10.1289/ehp.99107297. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pohl H. R., Tylenda C. A. Breast-feeding exposure of infants to selected pesticides: a public health viewpoint. Toxicol Ind Health. 2000 Feb;16(2):65–77. doi: 10.1177/074823370001600203. [DOI] [PubMed] [Google Scholar]
- Roeleveld N., Zielhuis G. A., Gabreëls F. The prevalence of mental retardation: a critical review of recent literature. Dev Med Child Neurol. 1997 Feb;39(2):125–132. doi: 10.1111/j.1469-8749.1997.tb07395.x. [DOI] [PubMed] [Google Scholar]
- Rogan W. J. Pollutants in breast milk. Arch Pediatr Adolesc Med. 1996 Sep;150(9):981–990. doi: 10.1001/archpedi.1996.02170340095018. [DOI] [PubMed] [Google Scholar]
- Rowland Andrew S., Umbach David M., Stallone Lil, Naftel A. Jack, Bohlig E. Michael, Sandler Dale P. Prevalence of medication treatment for attention deficit-hyperactivity disorder among elementary school children in Johnston County, North Carolina. Am J Public Health. 2002 Feb;92(2):231–234. doi: 10.2105/ajph.92.2.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schade G., Heinzow B. Organochlorine pesticides and polychlorinated biphenyls in human milk of mothers living in northern Germany: current extent of contamination, time trend from 1986 to 1997 and factors that influence the levels of contamination. Sci Total Environ. 1998 Apr 23;215(1-2):31–39. doi: 10.1016/s0048-9697(98)00008-4. [DOI] [PubMed] [Google Scholar]
- Seidman D. S., Laor A., Stevenson D. K., Sivan E., Gale R., Shemer J. Macrosomia does not predict overweight in late adolescence in infants of diabetic mothers. Acta Obstet Gynecol Scand. 1998 Jan;77(1):58–62. doi: 10.1034/j.1600-0412.1998.770113.x. [DOI] [PubMed] [Google Scholar]
- Selevan S. G., Kimmel C. A., Mendola P. Identifying critical windows of exposure for children's health. Environ Health Perspect. 2000 Jun;108 (Suppl 3):451–455. doi: 10.1289/ehp.00108s3451. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith D. Worldwide trends in DDT levels in human breast milk. Int J Epidemiol. 1999 Apr;28(2):179–188. doi: 10.1093/ije/28.2.179. [DOI] [PubMed] [Google Scholar]
- Sørensen N., Murata K., Budtz-Jørgensen E., Weihe P., Grandjean P. Prenatal methylmercury exposure as a cardiovascular risk factor at seven years of age. Epidemiology. 1999 Jul;10(4):370–375. [PubMed] [Google Scholar]
- Vreugdenhil Hestien J. I., Lanting Caren I., Mulder Paul G. H., Boersma E. Rudy, Weisglas-Kuperus Nynke. Effects of prenatal PCB and dioxin background exposure on cognitive and motor abilities in Dutch children at school age. J Pediatr. 2002 Jan;140(1):48–56. doi: 10.1067/mpd.2002.119625. [DOI] [PubMed] [Google Scholar]
- Walkowiak J., Wiener J. A., Fastabend A., Heinzow B., Krämer U., Schmidt E., Steingrüber H. J., Wundram S., Winneke G. Environmental exposure to polychlorinated biphenyls and quality of the home environment: effects on psychodevelopment in early childhood. Lancet. 2001 Nov 10;358(9293):1602–1607. doi: 10.1016/S0140-6736(01)06654-5. [DOI] [PubMed] [Google Scholar]
- Yeargin-Allsopp Marshalyn, Rice Catherine, Karapurkar Tanya, Doernberg Nancy, Boyle Coleen, Murphy Catherine. Prevalence of autism in a US metropolitan area. JAMA. 2003 Jan 1;289(1):49–55. doi: 10.1001/jama.289.1.49. [DOI] [PubMed] [Google Scholar]
- Zhou T., Ross D. G., DeVito M. J., Crofton K. M. Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol Sci. 2001 May;61(1):76–82. doi: 10.1093/toxsci/61.1.76. [DOI] [PubMed] [Google Scholar]
- de la Burdé B., Choate M. L. Early asymptomatic lead exposure and development at school age. J Pediatr. 1975 Oct;87(4):638–642. doi: 10.1016/s0022-3476(75)80845-6. [DOI] [PubMed] [Google Scholar]
- van den Berg B. J., Christianson R. E., Oechsli F. W. The California Child Health and Development Studies of the School of Public Health, University of California at Berkeley. Paediatr Perinat Epidemiol. 1988 Jul;2(3):265–282. doi: 10.1111/j.1365-3016.1988.tb00218.x. [DOI] [PubMed] [Google Scholar]
