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. 2025 Aug 12;36(9):ar111. doi: 10.1091/mbc.E25-02-0057

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© 2025 Alabi et al. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution 4.0 International Creative Commons CC-BY 4.0 License (https://creativecommons.org/licenses/by/4.0/).

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FIGURE 2: — Acute lamin depletion does not drive changes in nuclear morphology. (A–C) Immunofluorescence of mNeonGreen after 16 h of DMSO or auxin treatment in mNG-AID-LA/C (A), mNG-AID-LB1 (B), and mNG-AID-LB2 (C) cells; scale bar, 10 µm. (D and E) Cross-sectional nuclear area (D) and nuclear circularity (E) after 16 h of DMSO or auxin treatment in mNG-AID-LA/C, mNG-AID-LB1, and mNG-AID-LB2 cells. n > 275 cells were analyzed per condition from three independent replicate experiments. ns indicates p > 0.05; **, p < 0.01; and *, p < 0.05 by pairwise t test. (F) The percentage of nuclei with blebs detected by blinded categorical scoring after 16 h of DMSO or auxin treatment in mNG-AID-LA/C, mNG-AID-LB1, and mNG-AID-LB2 cells. n > 400 cells were analyzed per condition from three independent replicate experiments.