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. 2003 Aug;111(10):1348–1351. doi: 10.1289/ehp.6124

Distribution and determinants of mouse allergen exposure in low-income New York City apartments.

Ginger L Chew 1, Matthew S Perzanowski 1, Rachel L Miller 1, Juan C Correa 1, Lori A Hoepner 1, Carlos M Jusino 1, Mark G Becker 1, Patrick L Kinney 1
PMCID: PMC1241617  PMID: 12896857

Abstract

Previous studies of mouse allergens and laboratory-animal-worker-related allergy and asthma suggest that quantifying mouse allergen levels in homes could augment our understanding of inner-city asthma. We hypothesized that levels of mouse allergen in inner-city homes would be related to certain household characteristics. Dust samples were collected from the kitchens and beds of 221 mothers enrolled in a prospective birth cohort study, 92 of African American and 129 of Dominican ethnicity. Samples were analyzed for mouse urinary protein. The geometric mean for kitchen samples was 4.6 micro g/g [95% confidence interval (95% CI), 3.2-6.5] and for bed samples was 0.9 micro g/g (95% CI, 0.8-1.1). The variables associated with mouse allergen levels in the home were frequency of mouse sightings, use of traps or pesticides for mice, presence of holes in ceilings or walls, absence of a cat, and living in a building with fewer than eight floors. Statistically significant neighborhood differences in levels of mouse allergen and report of rodents in the home were also observed. In conclusion, mouse allergen was prevalent among inner-city apartments, and the positive predictive value of self-reported frequent mouse sightings was high (90% for kitchens). However, high levels of mouse allergen were also found in many homes where mothers reported never seeing mice.

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Selected References

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  1. Call R. S., Smith T. F., Morris E., Chapman M. D., Platts-Mills T. A. Risk factors for asthma in inner city children. J Pediatr. 1992 Dec;121(6):862–866. doi: 10.1016/s0022-3476(05)80329-4. [DOI] [PubMed] [Google Scholar]
  2. Carr W., Zeitel L., Weiss K. Variations in asthma hospitalizations and deaths in New York City. Am J Public Health. 1992 Jan;82(1):59–65. doi: 10.2105/ajph.82.1.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chew G. L., Burge H. A., Dockery D. W., Muilenberg M. L., Weiss S. T., Gold D. R. Limitations of a home characteristics questionnaire as a predictor of indoor allergen levels. Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1536–1541. doi: 10.1164/ajrccm.157.5.9708011. [DOI] [PubMed] [Google Scholar]
  4. Gelber L. E., Seltzer L. H., Bouzoukis J. K., Pollart S. M., Chapman M. D., Platts-Mills T. A. Sensitization and exposure to indoor allergens as risk factors for asthma among patients presenting to hospital. Am Rev Respir Dis. 1993 Mar;147(3):573–578. doi: 10.1164/ajrccm/147.3.573. [DOI] [PubMed] [Google Scholar]
  5. Hollander A., Van Run P., Spithoven J., Heederik D., Doekes G. Exposure of laboratory animal workers to airborne rat and mouse urinary allergens. Clin Exp Allergy. 1997 Jun;27(6):617–626. [PubMed] [Google Scholar]
  6. Krakowiak A., Szulc B., Górski P. Allergy to laboratory animals in children of parents occupationally exposed to mice, rats and hamsters. Eur Respir J. 1999 Aug;14(2):352–356. doi: 10.1034/j.1399-3003.1999.14b19.x. [DOI] [PubMed] [Google Scholar]
  7. Litonjua A. A., Carey V. J., Burge H. A., Weiss S. T., Gold D. R. Exposure to cockroach allergen in the home is associated with incident doctor-diagnosed asthma and recurrent wheezing. J Allergy Clin Immunol. 2001 Jan;107(1):41–47. doi: 10.1067/mai.2001.111143. [DOI] [PubMed] [Google Scholar]
  8. Litonjua A. A., Carey V. J., Weiss S. T., Gold D. R. Race, socioeconomic factors, and area of residence are associated with asthma prevalence. Pediatr Pulmonol. 1999 Dec;28(6):394–401. doi: 10.1002/(sici)1099-0496(199912)28:6<394::aid-ppul2>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  9. Lorusso J. R., Moffat S., Ohman J. L., Jr Immunologic and biochemical properties of the major mouse urinary allergen (Mus m 1). J Allergy Clin Immunol. 1986 Nov;78(5 Pt 1):928–937. doi: 10.1016/0091-6749(86)90242-3. [DOI] [PubMed] [Google Scholar]
  10. Luczynska C. M., Arruda L. K., Platts-Mills T. A., Miller J. D., Lopez M., Chapman M. D. A two-site monoclonal antibody ELISA for the quantification of the major Dermatophagoides spp. allergens, Der p I and Der f I. J Immunol Methods. 1989 Mar 31;118(2):227–235. doi: 10.1016/0022-1759(89)90010-0. [DOI] [PubMed] [Google Scholar]
  11. Ohman J. L., Jr, Hagberg K., MacDonald M. R., Jones R. R., Jr, Paigen B. J., Kacergis J. B. Distribution of airborne mouse allergen in a major mouse breeding facility. J Allergy Clin Immunol. 1994 Nov;94(5):810–817. doi: 10.1016/0091-6749(94)90147-3. [DOI] [PubMed] [Google Scholar]
  12. Ownby Dennis R., Johnson Christine Cole, Peterson Edward L. Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age. JAMA. 2002 Aug 28;288(8):963–972. doi: 10.1001/jama.288.8.963. [DOI] [PubMed] [Google Scholar]
  13. Phipatanakul W., Eggleston P. A., Wright E. C., Wood R. A. Mouse allergen. I. The prevalence of mouse allergen in inner-city homes. The National Cooperative Inner-City Asthma Study. J Allergy Clin Immunol. 2000 Dec;106(6):1070–1074. doi: 10.1067/mai.2000.110796. [DOI] [PubMed] [Google Scholar]
  14. Pollart S. M., Smith T. F., Morris E. C., Gelber L. E., Platts-Mills T. A., Chapman M. D. Environmental exposure to cockroach allergens: analysis with monoclonal antibody-based enzyme immunoassays. J Allergy Clin Immunol. 1991 Feb;87(2):505–510. doi: 10.1016/0091-6749(91)90009-d. [DOI] [PubMed] [Google Scholar]
  15. Renström A., Gordon S., Larsson P. H., Tee R. D., Newman Taylor A. J., Malmberg P. Comparison of a radioallergosorbent (RAST) inhibition method and a monoclonal enzyme linked immunosorbent assay (ELISA) for aeroallergen measurement. Clin Exp Allergy. 1997 Nov;27(11):1314–1321. [PubMed] [Google Scholar]
  16. Renström A., Karlsson A. S., Malmberg P., Larsson P. H., van Hage-Hamsten M. Working with male rodents may increase risk of allergy to laboratory animals. Allergy. 2001 Oct;56(10):964–970. doi: 10.1034/j.1398-9995.2001.00899.x. [DOI] [PubMed] [Google Scholar]
  17. Renström A., Malmberg P., Larsson K., Sundblad B. M., Larsson P. H. Prospective study of laboratory-animal allergy: factors predisposing to sensitization and development of allergic symptoms. Allergy. 1994 Aug;49(7):548–552. doi: 10.1111/j.1398-9995.1994.tb01127.x. [DOI] [PubMed] [Google Scholar]
  18. Rosenstreich D. L., Eggleston P., Kattan M., Baker D., Slavin R. G., Gergen P., Mitchell H., McNiff-Mortimer K., Lynn H., Ownby D. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N Engl J Med. 1997 May 8;336(19):1356–1363. doi: 10.1056/NEJM199705083361904. [DOI] [PubMed] [Google Scholar]
  19. Schumacher M. J., Tait B. D., Holmes M. C. Allergy to murine antigens in a biological research institute. J Allergy Clin Immunol. 1981 Oct;68(4):310–318. doi: 10.1016/0091-6749(81)90157-3. [DOI] [PubMed] [Google Scholar]
  20. Sporik R., Holgate S. T., Platts-Mills T. A., Cogswell J. J. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med. 1990 Aug 23;323(8):502–507. doi: 10.1056/NEJM199008233230802. [DOI] [PubMed] [Google Scholar]

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