Abstract
Children and their parents in residences are often protected by insecticides from nuisance and disease-bearing mosquitoes. The annual worldwide consumption of the four major types of residential insecticide products--aerosols, mosquito coils, liquid vaporizers, and vaporizing mats--is in the billions of units. Mosquito coils are burned indoors and outdoors in East Asia and to a limited extent in other parts of the world, including the United States. Coils consist of an insecticide/repellant, organic fillers capable of burning with smoldering, binder, and additives such as synergists, dyes, and fungicide. The number of coil users in China is in the millions. In Indonesia alone, an estimated seven billion coils are purchased annually. Coils containing pyrethroid insecticides, particularly d-allethrin, may contain octachlorodipropyl ether (S-2, S-421) as a synergist or active ingredient. Use of those coils likely exposes children and adults to some level of bis(chloromethyl)ether (BCME). BCME is formed from formaldehyde and hydrogen chloride, combustion products formed from the slow smoldering (about 8 hr/coil) of the mosquito coils. Because BCME is an extremely potent lung carcinogen, the nature and extent of prolonged exposures that recur in homes during the mosquito season in tropical regions must be evaluated with respect to health. In a small analytical study, coils purchased in Indonesia and in the United States contained highly variable amounts of S-2. Some coils that contained S-2 were not labeled, making it impossible for consumers to make an informed decision about coil contents. Mosquito coils containing S-2 are unregistered, and their use is illegal in the United States. Indoor air monitoring under conditions that represent conditions of use in tropical settings and epidemiology to assess health impacts of coil use are essential to permit responsible regulatory decisions regarding continuing S-2 use.
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Selected References
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- Cheng V., Lee H. R., Chen C. S. Morphological changes in the respiratory system of mice after inhalation of mosquito-coil smoke. Toxicol Lett. 1992 Sep;62(2-3):163–177. doi: 10.1016/0378-4274(92)90019-g. [DOI] [PubMed] [Google Scholar]
- Fishbein L., Fawkes J., Falk H. L., Jordan S. Thin-layer chromatography of rat bile and urine following intravenous administration of the pesticidal synergist octachlorodipropyl ether. J Chromatogr. 1968 Oct 8;37(2):256–263. doi: 10.1016/s0021-9673(01)99103-4. [DOI] [PubMed] [Google Scholar]
- Kallos G. J., Solomon R. A. Investigations of the formation of bis-chloromethyl ether in simulated hydrogen chloride-formaldehyde atmospheric environments. Am Ind Hyg Assoc J. 1973 Nov;34(11):469–473. doi: 10.1080/0002889738506883. [DOI] [PubMed] [Google Scholar]
- Liu W. K., Sun S. E. Ultrastructural changes of tracheal epithelium and alveolar macrophages of rats exposed to mosquito coil smoke. Toxicol Lett. 1988 May;41(2):145–157. doi: 10.1016/0378-4274(88)90088-4. [DOI] [PubMed] [Google Scholar]
- Miyazaki T., Kaneko S., Horii S., Yamagishi T. Identification of the synergist bis(2,3,3,3-tetrachloropropyl)ether in human milk. Bull Environ Contam Toxicol. 1981 Mar;26(3):420–423. doi: 10.1007/BF01622113. [DOI] [PubMed] [Google Scholar]
- Miyazaki T. Residues of the synergist S-421 in human milk collected from the Tokyo metropolitan area. Bull Environ Contam Toxicol. 1982 Nov;29(5):566–569. doi: 10.1007/BF01669622. [DOI] [PubMed] [Google Scholar]
- Mulla M. S., Thavara U., Tawatsin A., Kong-Ngamsuk W., Chompoosri J. Mosquito burden and impact on the poor: measures and costs for personal protection in some communities in Thailand. J Am Mosq Control Assoc. 2001 Sep;17(3):153–159. [PubMed] [Google Scholar]
- Nelson N. The chloroethers--occupational carcinogens: a summary of laboratory and epidemiology studies. Ann N Y Acad Sci. 1976;271:81–90. doi: 10.1111/j.1749-6632.1976.tb23096.x. [DOI] [PubMed] [Google Scholar]
- Pauluhn J., Mohr U. Inhalation studies in laboratory animals--current concepts and alternatives. Toxicol Pathol. 2000 Sep-Oct;28(5):734–753. doi: 10.1177/019262330002800514. [DOI] [PubMed] [Google Scholar]
- Van Duuren B. L., Sivak A., Goldschmidt B. M., Katz C., Melchionne S. Carcinogenicity of halo-ethers. J Natl Cancer Inst. 1969 Aug;43(2):481–486. [PubMed] [Google Scholar]