Skip to main content
Environmental Health Perspectives logoLink to Environmental Health Perspectives
. 2003 Oct;111(13):1590–1594. doi: 10.1289/ehp.6288

Antibiotics in dust originating from a pig-fattening farm: a new source of health hazard for farmers?

Gerd Hamscher 1, Heike Theresia Pawelzick 1, Silke Sczesny 1, Heinz Nau 1, Jörg Hartung 1
PMCID: PMC1241679  PMID: 14527837

Abstract

Pig-house dust originates from feed, bedding, feces, and the animals themselves. If the animals receive drugs such as antibiotics, residues of these substances may occur in manure, in the air, or on surfaces of the respective animal house. In a retrospective study, we investigated dust samples collected during two decades from the same piggery for the occurrence of various antibiotics. In 90% of these samples, we detected up to five different antibiotics, including tylosin, various tetracyclines, sulfamethazine, and chloramphenicol, in total amounts up to 12.5 mg/kg dust. High dust exposure in animal confinement buildings is believed to be a respiratory health hazard because of the high content of microorganisms, endotoxins, and allergens. Further risks may arise from the inhalation of dust contaminated with a cocktail of antibiotics. Apart from that, our data provide first evidence for a new route of entry for veterinary drugs in the environment.

Full Text

The Full Text of this article is available as a PDF (175.2 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barberá E., de la Cuadra J. Occupational airborne allergic contact dermatitis from tylosin. Contact Dermatitis. 1989 Apr;20(4):308–309. doi: 10.1111/j.1600-0536.1989.tb03155.x. [DOI] [PubMed] [Google Scholar]
  2. Caraffini S., Assalve D., Stingeni L., Lisi P. Tylosin, an airborne contact allergen in veterinarians. Contact Dermatitis. 1994 Nov;31(5):327–328. doi: 10.1111/j.1600-0536.1994.tb02034.x. [DOI] [PubMed] [Google Scholar]
  3. Choquet-Kastylevsky Geneviève, Vial Thierry, Descotes Jacques. Allergic adverse reactions to sulfonamides. Curr Allergy Asthma Rep. 2002 Jan;2(1):16–25. doi: 10.1007/s11882-002-0033-y. [DOI] [PubMed] [Google Scholar]
  4. Danese P., Zanca A., Bertazzoni M. G. Occupational contact dermatitis from tylosin. Contact Dermatitis. 1994 Feb;30(2):122–123. doi: 10.1111/j.1600-0536.1994.tb00587.x. [DOI] [PubMed] [Google Scholar]
  5. Daughton C. G., Ternes T. A. Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect. 1999 Dec;107 (Suppl 6):907–938. doi: 10.1289/ehp.99107s6907. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Halling-Sørensen B., Nors Nielsen S., Lanzky P. F., Ingerslev F., Holten Lützhøft H. C., Jørgensen S. E. Occurrence, fate and effects of pharmaceutical substances in the environment--a review. Chemosphere. 1998 Jan;36(2):357–393. doi: 10.1016/s0045-6535(97)00354-8. [DOI] [PubMed] [Google Scholar]
  7. Hamscher G., Sczesny S., Abu-Qare A., Höper H., Nau H. Stoffe mit pharmakologischer Wirkung einschliesslich hormonell aktiver Substanzen in der Umwelt: Nachweis von Tetracyclinen in güllegedüngten Böden. Dtsch Tierarztl Wochenschr. 2000 Aug;107(8):332–334. [PubMed] [Google Scholar]
  8. Hamscher Gerd, Sczesny Silke, Höper Heinrich, Nau Heinz. Determination of persistent tetracycline residues in soil fertilized with liquid manure by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Anal Chem. 2002 Apr 1;74(7):1509–1518. doi: 10.1021/ac015588m. [DOI] [PubMed] [Google Scholar]
  9. Hartung J. Gas- und partikelförmige Emissionen aus Ställen der Tierproduktion. Dtsch Tierarztl Wochenschr. 1995 Jul;102(7):283–288. [PubMed] [Google Scholar]
  10. Heberer Thomas. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett. 2002 May 10;131(1-2):5–17. doi: 10.1016/s0378-4274(02)00041-3. [DOI] [PubMed] [Google Scholar]
  11. Hjorth N., Roed-Petersen J. Allergic contact dermatitis in veterinary surgeons. Contact Dermatitis. 1980 Jan;6(1):27–29. doi: 10.1111/j.1600-0536.1980.tb03885.x. [DOI] [PubMed] [Google Scholar]
  12. Holt D., Harvey D., Hurley R. Chloramphenicol toxicity. Adverse Drug React Toxicol Rev. 1993 Summer;12(2):83–95. [PubMed] [Google Scholar]
  13. Iversen M., Kirychuk S., Drost H., Jacobson L. Human health effects of dust exposure in animal confinement buildings. J Agric Saf Health. 2000 Nov;6(4):283–288. doi: 10.13031/2013.1911. [DOI] [PubMed] [Google Scholar]
  14. Kolpin Dana W., Furlong Edward T., Meyer Michael T., Thurman E. Michael, Zaugg Steven D., Barber Larry B., Buxton Herbert T. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environ Sci Technol. 2002 Mar 15;36(6):1202–1211. doi: 10.1021/es011055j. [DOI] [PubMed] [Google Scholar]
  15. Lindsey M. E., Meyer T. M., Thurman E. M. Analysis of trace levels of sulfonamide and tetracycline antimicrobials in groundwater and surface water using solid-phase extraction and liquid chromatography/mass spectrometry. Anal Chem. 2001 Oct 1;73(19):4640–4646. doi: 10.1021/ac010514w. [DOI] [PubMed] [Google Scholar]
  16. Nowak D. Die Wirkung von Stalluftbestandteilen, insbesondere in Schweineställen, aus arbeitsmedizinischer Sicht. Dtsch Tierarztl Wochenschr. 1998 Jun;105(6):225–234. [PubMed] [Google Scholar]
  17. Nwosu V. C. Antibiotic resistance with particular reference to soil microorganisms. Res Microbiol. 2001 Jun;152(5):421–430. doi: 10.1016/s0923-2508(01)01215-3. [DOI] [PubMed] [Google Scholar]
  18. Pedersen S., Nonnenmann M., Rautiainen R., Demmers T. G., Banhazi T., Lyngbye M. Dust in pig buildings. J Agric Saf Health. 2000 Nov;6(4):261–274. doi: 10.13031/2013.1909. [DOI] [PubMed] [Google Scholar]
  19. Platz S., Scherer M., Unshelm J. Untersuchungen zur Belastung von Mastschweinen sowie der Umgebung von Mastschweineställen durch atembaren Feinstaub, stallspezifische Bakterien und Ammoniak. Zentralbl Hyg Umweltmed. 1995 Jan;196(5):399–415. [PubMed] [Google Scholar]
  20. Radon Katja, Danuser Brigitta, Iversen Martin, Monso Eduard, Weber Christoph, Hartung Jörg, Donham Kelley, Palmgren Urban, Nowak Dennis. Air contaminants in different European farming environments. Ann Agric Environ Med. 2002;9(1):41–48. [PubMed] [Google Scholar]
  21. Witte W. Medical consequences of antibiotic use in agriculture. Science. 1998 Feb 13;279(5353):996–997. doi: 10.1126/science.279.5353.996. [DOI] [PubMed] [Google Scholar]

Articles from Environmental Health Perspectives are provided here courtesy of National Institute of Environmental Health Sciences

RESOURCES