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. 2003 Oct;111(13):1630–1639. doi: 10.1289/ehp.6205

Comparable measures of cognitive function in human infants and laboratory animals to identify environmental health risks to children.

Carolyn Sharbaugh 1, Susan Marie Viet 1, Alexa Fraser 1, Suzanne B McMaster 1
PMCID: PMC1241686  PMID: 14527843

Abstract

The importance of including neurodevelopmental end points in environmental studies is clear. A validated measure of cognitive function in human infants that also has a homologous or parallel test in laboratory animal studies will provide a valuable approach for large-scale studies. Such a comparable test will allow researchers to observe the effect of environmental neurotoxicants in animals and relate those findings to humans. In this article, we present the results of a review of post-1990, peer-reviewed literature and current research examining measures of cognitive function that can be applied to both human infants (0-12 months old) and laboratory animals. We begin with a discussion of the definition of cognitive function and important considerations in cross-species research. We then describe identified comparable measures, providing a description of the test in human infants and animal subjects. Available information on test reliability, validity, and population norms, as well as test limitations and constraints, is also presented.

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Selected References

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