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. 2004 Jan;112(1):9–17. doi: 10.1289/ehp.6559

Brominated flame retardants: cause for concern?

Linda S Birnbaum 1, Daniele F Staskal 1
PMCID: PMC1241790  PMID: 14698924

Abstract

Brominated flame retardants (BFRs) have routinely been added to consumer products for several decades in a successful effort to reduce fire-related injury and property damage. Recently, concern for this emerging class of chemicals has risen because of the occurrence of several classes of BFRs in the environment and in human biota. The widespread production and use of BFRs; strong evidence of increasing contamination of the environment, wildlife, and people; and limited knowledge of potential effects heighten the importance of identifying emerging issues associated with the use of BFRs. In this article, we briefly review scientific issues associated with the use of tetrabromobisphenol A, hexabromocyclododecane, and three commercial mixtures of polybrominated diphenyl ethers and discuss data gaps. Overall, the toxicology database is very limited; the current literature is incomplete and often conflicting. Available data, however, raise concern over the use of certain classes of brominated flame retardants.

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Selected References

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  1. Alaee Mehran, Wenning Richard J. The significance of brominated flame retardants in the environment: current understanding, issues and challenges. Chemosphere. 2002 Feb;46(5):579–582. doi: 10.1016/s0045-6535(01)00224-7. [DOI] [PubMed] [Google Scholar]
  2. Betts Kellyn S. Rapidly rising PBDE levels in North America. Environ Sci Technol. 2002 Feb 1;36(3):50A–52A. doi: 10.1021/es022197w. [DOI] [PubMed] [Google Scholar]
  3. Birnbaum L. S., Couture L. A. Disposition of octachlorodibenzo-p-dioxin (OCDD) in male rats. Toxicol Appl Pharmacol. 1988 Mar 30;93(1):22–30. doi: 10.1016/0041-008x(88)90022-1. [DOI] [PubMed] [Google Scholar]
  4. Birnbaum Linda S., Staskal Daniele F., Diliberto Janet J. Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs). Environ Int. 2003 Sep;29(6):855–860. doi: 10.1016/S0160-4120(03)00106-5. [DOI] [PubMed] [Google Scholar]
  5. Bocio A., Llobet J. M., Domingo J. L., Corbella J., Teixidó A., Casas C. Polybrominated diphenyl ethers (PBDEs) in foodstuffs: human exposure through the diet. J Agric Food Chem. 2003 May 7;51(10):3191–3195. doi: 10.1021/jf0340916. [DOI] [PubMed] [Google Scholar]
  6. Boon Jan P., Lewis Wilma E., Tjoen-A-Choy Michael R., Allchin Colin R., Law Robin J., De Boer Jacob, Ten Hallers-Tjabbes Cato C., Zegers Bart N. Levels of polybrominated diphenyl ether (PBDE) flame retardants in animals representing different trophic levels of the North Sea food Web. Environ Sci Technol. 2002 Oct 1;36(19):4025–4032. doi: 10.1021/es0158298. [DOI] [PubMed] [Google Scholar]
  7. Branchi Igor, Alleva Enrico, Costa Lucio G. Effects of perinatal exposure to a polybrominated diphenyl ether (PBDE 99) on mouse neurobehavioural development. Neurotoxicology. 2002 Sep;23(3):375–384. doi: 10.1016/s0161-813x(02)00078-5. [DOI] [PubMed] [Google Scholar]
  8. Chauhan K. R., Kodavanti P. R., McKinney J. D. Assessing the role of ortho-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein. Toxicol Appl Pharmacol. 2000 Jan 1;162(1):10–21. doi: 10.1006/taap.1999.8826. [DOI] [PubMed] [Google Scholar]
  9. Chen G., Konstantinov A. D., Chittim B. G., Joyce E. M., Bols N. C., Bunce N. J. Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor mediated pathway. Environ Sci Technol. 2001 Sep 15;35(18):3749–3756. doi: 10.1021/es0107475. [DOI] [PubMed] [Google Scholar]
  10. Choi Jae-Won, Fujimaki T. Susumu, Kitamura Kimiyoshi, Hashimoto Shunji, Ito Hiroyasu, Suzuki Noriyuki, Sakai Shin-ichi, Morita Masatoshi. Polybrominated dibenzo-p-dioxins, dibenzofurans, and diphenyl ethers in Japanese human adipose tissue. Environ Sci Technol. 2003 Mar 1;37(5):817–821. doi: 10.1021/es0258780. [DOI] [PubMed] [Google Scholar]
  11. Covaci Adrian, de Boer Jacob, Ryan John Jake, Voorspoels Stefan, Schepens Paul. Determination of polybrominated diphenyl ethers and polychlorinated biphenyls in human adipose tissue by large-volume injection-narrow-bore capillary gas chromatography/electron impact low-resolution mass spectrometry. Anal Chem. 2002 Feb 15;74(4):790–798. doi: 10.1021/ac010784e. [DOI] [PubMed] [Google Scholar]
  12. Dunckel A. E. An updating on the polybrominated biphenyl disaster in Michigan. J Am Vet Med Assoc. 1975 Nov 1;167(9):838–841. [PubMed] [Google Scholar]
  13. Dybing E., Söderlund E. J., Nelson S. D. Irreversible macromolecular binding of the flame retardant tris-(2, 3-dibromopropyl)phosphate in vitro and in vivo. Dev Toxicol Environ Sci. 1980;8:265–268. [PubMed] [Google Scholar]
  14. Eriksson P., Jakobsson E., Fredriksson A. Brominated flame retardants: a novel class of developmental neurotoxicants in our environment? Environ Health Perspect. 2001 Sep;109(9):903–908. doi: 10.1289/ehp.01109903. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Eriksson P., Viberg H., Jakobsson E., Orn U., Fredriksson A. A brominated flame retardant, 2,2',4,4',5-pentabromodiphenyl ether: uptake, retention, and induction of neurobehavioral alterations in mice during a critical phase of neonatal brain development. Toxicol Sci. 2002 May;67(1):98–103. doi: 10.1093/toxsci/67.1.98. [DOI] [PubMed] [Google Scholar]
  16. Fries G. F. Bioavailability of soil-borne polybrominated biphenyls ingested by farm animals. J Toxicol Environ Health. 1985;16(3-4):565–579. doi: 10.1080/15287398509530764. [DOI] [PubMed] [Google Scholar]
  17. Haddow J. E., Palomaki G. E., Allan W. C., Williams J. R., Knight G. J., Gagnon J., O'Heir C. E., Mitchell M. L., Hermos R. J., Waisbren S. E. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med. 1999 Aug 19;341(8):549–555. doi: 10.1056/NEJM199908193410801. [DOI] [PubMed] [Google Scholar]
  18. Hakk H., Larsen G., Klasson-Wehler E. Tissue disposition, excretion and metabolism of 2,2',4,4',5-pentabromodiphenyl ether (BDE-99) in the male Sprague-Dawley rat. Xenobiotica. 2002 May;32(5):369–382. doi: 10.1080/00498250110119117. [DOI] [PubMed] [Google Scholar]
  19. Hakk Heldur, Letcher Robert J. Metabolism in the toxicokinetics and fate of brominated flame retardants--a review. Environ Int. 2003 Sep;29(6):801–828. doi: 10.1016/S0160-4120(03)00109-0. [DOI] [PubMed] [Google Scholar]
  20. Hale Robert C., La Guardia Mark J., Harvey Ellen, Mainor T. Matt. Potential role of fire retardant-treated polyurethane foam as a source of brominated diphenyl ethers to the US environment. Chemosphere. 2002 Feb;46(5):729–735. doi: 10.1016/s0045-6535(01)00237-5. [DOI] [PubMed] [Google Scholar]
  21. Hallgren S., Sinjari T., Håkansson H., Darnerud P. O. Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch Toxicol. 2001 Jun;75(4):200–208. doi: 10.1007/s002040000208. [DOI] [PubMed] [Google Scholar]
  22. Hughes M. F., Edwards B. C., Mitchell C. T., Bhooshan B. In vitro dermal absorption of flame retardant chemicals. Food Chem Toxicol. 2001 Dec;39(12):1263–1270. doi: 10.1016/s0278-6915(01)00074-6. [DOI] [PubMed] [Google Scholar]
  23. Ikonomou Michael G., Rayne Sierra, Addison Richard F. Exponential increases of the brominated flame retardants, polybrominated diphenyl ethers, in the Canadian Arctic from 1981 to 2000. Environ Sci Technol. 2002 May 1;36(9):1886–1892. doi: 10.1021/es011401x. [DOI] [PubMed] [Google Scholar]
  24. Ikonomou Michael G., Rayne Sierra, Fischer Maike, Fernandez Marc P., Cretney Walter. Occurrence and congener profiles of polybrominated diphenyl ethers (PBDEs) in environmental samples from coastal British Columbia, Canada. Chemosphere. 2002 Feb;46(5):649–663. doi: 10.1016/s0045-6535(01)00229-6. [DOI] [PubMed] [Google Scholar]
  25. Jakobsson Kristina, Thuresson Kaj, Rylander Lars, Sjödin Andreas, Hagmar Lars, Bergman Ake. Exposure to polybrominated diphenyl ethers and tetrabromobisphenol A among computer technicians. Chemosphere. 2002 Feb;46(5):709–716. doi: 10.1016/s0045-6535(01)00235-1. [DOI] [PubMed] [Google Scholar]
  26. Kester Monique H. A., Bulduk Sema, van Toor Hans, Tibboel Dick, Meinl Walter, Glatt Hansruedi, Falany Charles N., Coughtrie Michael W. H., Schuur A. Gerlienke, Brouwer Abraham. Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters. J Clin Endocrinol Metab. 2002 Mar;87(3):1142–1150. doi: 10.1210/jcem.87.3.8311. [DOI] [PubMed] [Google Scholar]
  27. Kitamura Shigeyuki, Jinno Norimasa, Ohta Shigeru, Kuroki Hiroaki, Fujimoto Nariaki. Thyroid hormonal activity of the flame retardants tetrabromobisphenol A and tetrachlorobisphenol A. Biochem Biophys Res Commun. 2002 Apr 26;293(1):554–559. doi: 10.1016/S0006-291X(02)00262-0. [DOI] [PubMed] [Google Scholar]
  28. Kodavanti Prasada Rao S., Derr-Yellin Ethel C. Differential effects of polybrominated diphenyl ethers and polychlorinated biphenyls on [3H]arachidonic acid release in rat cerebellar granule neurons. Toxicol Sci. 2002 Aug;68(2):451–457. doi: 10.1093/toxsci/68.2.451. [DOI] [PubMed] [Google Scholar]
  29. Letcher Robert J., Behnisch Peter A. The state-of-the-science and trends of brominated flame retardants in the environment: present knowledge and future directions. Environ Int. 2003 Sep;29(6):663–664. doi: 10.1016/S0160-4120(03)00122-3. [DOI] [PubMed] [Google Scholar]
  30. Mazdai Anita, Dodder Nathan G., Abernathy Mary Pell, Hites Ronald A., Bigsby Robert M. Polybrominated diphenyl ethers in maternal and fetal blood samples. Environ Health Perspect. 2003 Jul;111(9):1249–1252. doi: 10.1289/ehp.6146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Meerts I. A., Letcher R. J., Hoving S., Marsh G., Bergman A., Lemmen J. G., van der Burg B., Brouwer A. In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PDBEs, and polybrominated bisphenol A compounds. Environ Health Perspect. 2001 Apr;109(4):399–407. doi: 10.1289/ehp.01109399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Meerts I. A., van Zanden J. J., Luijks E. A., van Leeuwen-Bol I., Marsh G., Jakobsson E., Bergman A., Brouwer A. Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicol Sci. 2000 Jul;56(1):95–104. doi: 10.1093/toxsci/56.1.95. [DOI] [PubMed] [Google Scholar]
  33. Meironyté Guvenius D., Bergman A., Norén K. Polybrominated diphenyl ethers in Swedish human liver and adipose tissue. Arch Environ Contam Toxicol. 2001 May;40(4):564–570. doi: 10.1007/s002440010211. [DOI] [PubMed] [Google Scholar]
  34. Meironyté D., Norén K., Bergman A. Analysis of polybrominated diphenyl ethers in Swedish human milk. A time-related trend study, 1972-1997. J Toxicol Environ Health A. 1999 Nov 26;58(6):329–341. doi: 10.1080/009841099157197. [DOI] [PubMed] [Google Scholar]
  35. Mercer H. D., Teske R. H., Condon R. J., Furr A., Meerdink G., Buck W., Fries G. Herd health status of animals exposed to polybrominated biphenyls (PBB). J Toxicol Environ Health. 1976 Nov;2(2):335–349. doi: 10.1080/15287397609529437. [DOI] [PubMed] [Google Scholar]
  36. Mills Graham, Yardley Anne-Marie, Thomas Mark, Blackmore Tim, Pithie Alan, Schroeder Bryan, Dickson Nigel. New Zealand's HIV infected population under active follow-up during 2000. N Z Med J. 2002 Apr 26;115(1152):173–176. [PubMed] [Google Scholar]
  37. Morck Anna, Hakk Heldur, Orn Ulrika, Klasson Wehler Eva. Decabromodiphenyl ether in the rat: absorption, distribution, metabolism, and excretion. Drug Metab Dispos. 2003 Jul;31(7):900–907. doi: 10.1124/dmd.31.7.900. [DOI] [PubMed] [Google Scholar]
  38. Morreale de Escobar G. The role of thyroid hormone in fetal neurodevelopment. J Pediatr Endocrinol Metab. 2001;14 (Suppl 6):1453–1462. [PubMed] [Google Scholar]
  39. Orn U., Klasson-Wehler E. Metabolism of 2,2',4,4'-tetrabromodiphenyl ether in rat and mouse. Xenobiotica. 1998 Feb;28(2):199–211. [PubMed] [Google Scholar]
  40. Petreas Myrto, She Jianwen, Brown F. Reber, Winkler Jennifer, Windham Gayle, Rogers Evan, Zhao Guomao, Bhatia Rajiv, Charles M. Judith. High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women. Environ Health Perspect. 2003 Jul;111(9):1175–1179. doi: 10.1289/ehp.6220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Pullen Sabine, Boecker Ronald, Tiegs Gisa. The flame retardants tetrabromobisphenol A and tetrabromobisphenol A-bisallylether suppress the induction of interleukin-2 receptor alpha chain (CD25) in murine splenocytes. Toxicology. 2003 Feb 14;184(1):11–22. doi: 10.1016/s0300-483x(02)00442-0. [DOI] [PubMed] [Google Scholar]
  42. Rice C. P., Chernyak S. M., Begnoche L., Quintal R., Hickey J. Comparisons of PBDE composition and concentration in fish collected from the Detroit River, MI and Des Plaines River, IL. Chemosphere. 2002 Nov;49(7):731–737. doi: 10.1016/s0045-6535(02)00398-3. [DOI] [PubMed] [Google Scholar]
  43. Schecter Arnold, Pavuk Marian, Päpke Olaf, Ryan John Jake, Birnbaum Linda, Rosen Robin. Polybrominated diphenyl ethers (PBDEs) in U.S. mothers' milk. Environ Health Perspect. 2003 Nov;111(14):1723–1729. doi: 10.1289/ehp.6466. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. She Jianwen, Petreas Myrto, Winkler Jennifer, Visita Patria, McKinney Michael, Kopec Dianne. PBDEs in the San Francisco Bay Area: measurements in harbor seal blubber and human breast adipose tissue. Chemosphere. 2002 Feb;46(5):697–707. doi: 10.1016/s0045-6535(01)00234-x. [DOI] [PubMed] [Google Scholar]
  45. Sjödin A., Hagmar L., Klasson-Wehler E., Kronholm-Diab K., Jakobsson E., Bergman A. Flame retardant exposure: polybrominated diphenyl ethers in blood from Swedish workers. Environ Health Perspect. 1999 Aug;107(8):643–648. doi: 10.1289/ehp.107-1566483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Szymańska J. A., Sapota A., Frydrych B. The disposition and metabolism of tetrabromobisphenol-A after a single i.p. dose in the rat. Chemosphere. 2001 Nov;45(4-5):693–700. doi: 10.1016/s0045-6535(01)00015-7. [DOI] [PubMed] [Google Scholar]
  47. Söderlund E., Dybing E., Nelson S. D. Nephrotoxicity and hepatotoxicity of tris(2,3-dibromopropyl)phosphate in the rat. Toxicol Appl Pharmacol. 1980 Nov;56(2):171–181. doi: 10.1016/0041-008x(80)90287-2. [DOI] [PubMed] [Google Scholar]
  48. Viberg Henrik, Fredriksson Anders, Eriksson Per. Neonatal exposure to the brominated flame retardant 2,2',4,4',5-pentabromodiphenyl ether causes altered susceptibility in the cholinergic transmitter system in the adult mouse. Toxicol Sci. 2002 May;67(1):104–107. doi: 10.1093/toxsci/67.1.104. [DOI] [PubMed] [Google Scholar]
  49. Zeiger E., Anderson B., Haworth S., Lawlor T., Mortelmans K., Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 (Suppl 9):1–109. [PubMed] [Google Scholar]
  50. Zhou T., Ross D. G., DeVito M. J., Crofton K. M. Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats. Toxicol Sci. 2001 May;61(1):76–82. doi: 10.1093/toxsci/61.1.76. [DOI] [PubMed] [Google Scholar]
  51. Zhou Tong, Taylor Michele M., DeVito Michael J., Crofton Kevin M. Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Toxicol Sci. 2002 Mar;66(1):105–116. doi: 10.1093/toxsci/66.1.105. [DOI] [PubMed] [Google Scholar]
  52. de Wit Cynthia A. An overview of brominated flame retardants in the environment. Chemosphere. 2002 Feb;46(5):583–624. doi: 10.1016/s0045-6535(01)00225-9. [DOI] [PubMed] [Google Scholar]

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