Huafu Li
Huafu Li
1
Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
2
Adult Stem Cell Laboratory, The Francis Crick Institute, London, United Kingdom
3
The Institute of Cancer Research, London, United Kingdom
4
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
1,2,3,4,†,#,
Chunming Wang
Chunming Wang
1
Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
4
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
1,4,†,#,
Linxiang Lan
Linxiang Lan
2
Adult Stem Cell Laboratory, The Francis Crick Institute, London, United Kingdom
3
The Institute of Cancer Research, London, United Kingdom
2,3,†,#,
Wenhui Wu
Wenhui Wu
1
Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
1,†,#,
Ian Evans
Ian Evans
2
Adult Stem Cell Laboratory, The Francis Crick Institute, London, United Kingdom
3
The Institute of Cancer Research, London, United Kingdom
2,3,
E Josue Ruiz
E Josue Ruiz
2
Adult Stem Cell Laboratory, The Francis Crick Institute, London, United Kingdom
3
The Institute of Cancer Research, London, United Kingdom
2,3,
Leping Yan
Leping Yan
5
Center of Scientific Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
5,
Zhijun Zhou
Zhijun Zhou
6
Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
6,
Joaquim M Oliveira
Joaquim M Oliveira
7
3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, University of Minho, Guimarães, Portugal
8
ICVS/3B’s – PT Government Associate Laboratory, Guimarães, Portugal
7,8,
Rui L Reis
Rui L Reis
7
3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, University of Minho, Guimarães, Portugal
8
ICVS/3B’s – PT Government Associate Laboratory, Guimarães, Portugal
7,8,
Zhenran Hu
Zhenran Hu
6
Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
6,
Wei Chen
Wei Chen
1
Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
1,
Axel Behrens
Axel Behrens
2
Adult Stem Cell Laboratory, The Francis Crick Institute, London, United Kingdom
3
The Institute of Cancer Research, London, United Kingdom
2,3,*,
Yulong He
Yulong He
1
Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
4
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
1,4,*,
Changhua Zhang
Changhua Zhang
1
Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
1,*
1
Digestive Diseases Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
2
Adult Stem Cell Laboratory, The Francis Crick Institute, London, United Kingdom
3
The Institute of Cancer Research, London, United Kingdom
4
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
5
Center of Scientific Research, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
6
Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States
7
3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, University of Minho, Guimarães, Portugal
8
ICVS/3B’s – PT Government Associate Laboratory, Guimarães, Portugal
✉*Correspondence: Changhua Zhang, zhchangh@mail.sysu.edu.cn; Yulong He, heyulong@mail.sysu.edu.cn; Axel Behrens, axel.behrens@crick.ac.uk
†
These authors share first authorship
Received 2025 Jul 24; Accepted 2025 Aug 8; Collection date 2025.
Keywords: gastric cancer, L-OHP resistance, homologous recombination, PARP1 inhibitors, organoid
Copyright © 2025 Li, Wang, Lan, Wu, Evans, Ruiz, Yan, Zhou, Oliveira, Reis, Hu, Chen, Behrens, He and Zhang.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.