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. 2025 Aug 28;13:1672461. doi: 10.3389/fcell.2025.1672461

Correction: PARP1 inhibitor combined with oxaliplatin efficiently suppresses oxaliplatin resistance in gastric cancer-derived organoids via homologous recombination and the base excision repair pathway

Huafu Li 1,2,3,4,†,#, Chunming Wang 1,4,†,#, Linxiang Lan 2,3,†,#, Wenhui Wu 1,†,#, Ian Evans 2,3, E Josue Ruiz 2,3, Leping Yan 5, Zhijun Zhou 6, Joaquim M Oliveira 7,8, Rui L Reis 7,8, Zhenran Hu 6, Wei Chen 1, Axel Behrens 2,3,*, Yulong He 1,4,*, Changhua Zhang 1,*
PMCID: PMC12424430  PMID: 40950400

There was a mistake in Figures 2, 4 as published. The wrong images were erroneously used for Figures 2G, 4A. The corrected Figures 2, 4 appear below.

FIGURE 2.

Microscopic images displaying DAPI and PARP1 staining for four samples labeled GC1(OXA), GCR1(OXA), GC2(OXA), and GCR2(OXA). Each row shows separate images for DAPI staining (blue), PARP1 staining (red), and a merged view, depicting cellular and nuclear structures under different staining conditions. Each sample has two sets of images illustrating variations in staining patterns and intensity.

PARP1 is upregulated in oxaliplatin resistance gastric cancer. (G) Representative images of PARP1 levels stained by immunofluorescence in organoid and tumors. The scale bar represents 20 µm for tumour images, 200 µm for organoid images.

FIGURE 4.

Four microscopic images comparing different conditions. Top left: OXA+OLP, with sparse scattered particles. Top right: OXA, showing abundant clustered particles. Bottom left: OLP, with moderate clustering. Bottom right: CON, displaying randomly distributed particles. Each panel has a scale bar.

PARP1 inhibition by Olaparib sensitizes gastric cancer to Oxaliplatin. (A–C) rGC1 organoids were treated with Olaparib + Oxaliplatin, Oxaliplatin, and Olaparib, respectively, before imaging (A), number of organoids (B), and size of organoids (C). The scale represents 500 µm.

The original version of this article has been updated.

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