Abstract
The central nervous system (CNS) is under constant immunosurveillance and influenced by immune-related effector molecules, including type 2-associated cytokines. Long-lasting type 2 immunity elicited by intestinal helminth infections can modify immune responses and wound repair locally and in peripheral tissues, but direct effects of helminth infection on the CNS are poorly understood. Here, we explore whether naturally-evoked type 2 immune responses can modify neuroimmune interactions for therapeutic gain in a mouse model of multiple sclerosis. Chronic infection with the helminth Trichinella spiralis ( Ts ) remodelled the neuroimmune landscape, including establishment of a robust population of CNS-resident T helper 2 cells, which subsequently minimized CNS inflammation and demyelination during experimental autoimmune encephalomyelitis (EAE). Clinical remission could be achieved with prophylactic or therapeutic infection, was Stat6 -dependent, and adoptive transfer of Th2 cells promoted remission in the absence of overt infection. These findings highlight the potential for harnessing type 2 immunity to modify outcomes of neuroinflammation and neurodegeneration.
Summary
Fettig et al. demonstrate that infection with the helminth Trichinella spiralis elicits rapid recruitment and sustained presence of Th2 cells in the central nervous system where they modify microglia function and are implicated in resolving autoimmune-mediated paralysis and neuroinflammation.
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