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. 1992 Jun;215(6):561–570. doi: 10.1097/00000658-199206000-00002

The Zollinger-Ellison syndrome. A collective surgical experience.

D R Farley 1, J A van Heerden 1, C S Grant 1, L J Miller 1, D M Ilstrup 1
PMCID: PMC1242503  PMID: 1352963

Abstract

A retrospective study of 90 surgically treated patients with the Zollinger-Ellison syndrome seen from 1958 through 1990 was performed. Fifteen patients had Zollinger-Ellison syndrome as a manifestation of multiple endocrine neoplasia type I. Preoperative tumor localization was positive in 46% of 54 patients studied. Gastrinomas were identified in 66% of patients, 38% of the tumors being malignant. Postoperative eugastrinemia was achieved in 11% of patients after a variety of surgical procedures. Exploratory laparotomy provides the only chance for cure and identifies the significant prognostic factors associated with long-term patient survival: small tumor size, extrapancreatic primary, and absence of tumor metastases.

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Selected References

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