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. 1992 Nov;216(5):547–553. doi: 10.1097/00000658-199211000-00004

An appraisal of pediatric liver transplantation from living relatives. Initial clinical experiences in 20 pediatric liver transplantations from living relatives as donors.

K Ozawa 1, S Uemoto 1, K Tanaka 1, K Kumada 1, Y Yamaoka 1, N Kobayashi 1, T Inamoto 1, Y Shimahara 1, K Mori 1, K Honda 1, et al.
PMCID: PMC1242671  PMID: 1280074

Abstract

The authors performed 20 liver transplantations from living related donors between June 1990 and July 1991. The 20 pediatric patients (14 biliary atresia, two Budd-Chiari syndrome, one liver cirrhosis after hepatitis C viral infection (HCV hepatitis), 1 progressive intrahepatic cholestasis, 1 liver cirrhosis, 1 protoporphyria) were transplanted with 11 left lobes, eight left lateral segments, and one right lobe. The choice of donors was restricted to the parents of the recipients. The immunosuppressive treatment consisted of FK 506 and steroids. Seventeen recipients are alive, 15 of whom are well and at home. Two recipients, who underwent emergency transplantation, died of postoperative complications. Another recipient died of accidental asphyxia at 6 months after the transplantation. All 20 donors had uneventful postoperative courses and were able to resume their normal social lives. The arterial ketone body ratio (AKBR) increased to above 1.0 within 2 days after the transplantation in all cases. Relatively mild rejection episodes were encountered in only two cases transplanted with ABO-compatible grafts, and these were treated successfully with steroids and FK 506.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asonuma K., Takaya S., Selby R., Okamoto R., Yamamoto Y., Yokoyama T., Todo S., Ozawa K., Starzl T. E. The clinical significance of the arterial ketone body ratio as an early indicator of graft viability in human liver transplantation. Transplantation. 1991 Jan;51(1):164–171. doi: 10.1097/00007890-199101000-00025. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Broelsch C. E., Emond J. C., Thistlethwaite J. R., Whitington P. F., Zucker A. R., Baker A. L., Aran P. F., Rouch D. A., Lichtor J. L. Liver transplantation, including the concept of reduced-size liver transplants in children. Ann Surg. 1988 Oct;208(4):410–420. doi: 10.1097/00000658-198810000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Broelsch C. E., Emond J. C., Whitington P. F., Thistlethwaite J. R., Baker A. L., Lichtor J. L. Application of reduced-size liver transplants as split grafts, auxiliary orthotopic grafts, and living related segmental transplants. Ann Surg. 1990 Sep;212(3):368–377. doi: 10.1097/00000658-199009000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Jamieson N. V., Sundberg R., Lindell S., Claesson K., Moen J., Vreugdenhil P. K., Wight D. G., Southard J. H., Belzer F. O. Preservation of the canine liver for 24-48 hours using simple cold storage with UW solution. Transplantation. 1988 Oct;46(4):517–522. doi: 10.1097/00007890-198810000-00010. [DOI] [PubMed] [Google Scholar]
  5. MERRILL J. P., MURRAY J. E., HARRISON J. H., GUILD W. R. Successful homotransplantation of the human kidney between identical twins. J Am Med Assoc. 1956 Jan 28;160(4):277–282. doi: 10.1001/jama.1956.02960390027008. [DOI] [PubMed] [Google Scholar]
  6. Matsuno N., Inoko H., Ando A., Nakatsuji T., Sato T., Itchikawa S., Sonoda T., Tsuji K. Importance of DQB as an indicator in living-related kidney transplant. Transplantation. 1990 Jan;49(1):208–212. doi: 10.1097/00007890-199001000-00046. [DOI] [PubMed] [Google Scholar]
  7. Otte J. B., de Ville de Goyet J., Alberti D., Balladur P., de Hemptinne B. The concept and technique of the split liver in clinical transplantation. Surgery. 1990 Jun;107(6):605–612. [PubMed] [Google Scholar]
  8. Raia S., Nery J. R., Mies S. Liver transplantation from live donors. Lancet. 1989 Aug 26;2(8661):497–497. doi: 10.1016/s0140-6736(89)92101-6. [DOI] [PubMed] [Google Scholar]
  9. Singer P. A., Siegler M., Whitington P. F., Lantos J. D., Emond J. C., Thistlethwaite J. R., Broelsch C. E. Ethics of liver transplantation with living donors. N Engl J Med. 1989 Aug 31;321(9):620–622. doi: 10.1056/NEJM198908313210919. [DOI] [PubMed] [Google Scholar]
  10. Smith B. Segmental liver transplantation from a living donor. J Pediatr Surg. 1969 Feb;4(1):126–132. doi: 10.1016/0022-3468(69)90193-6. [DOI] [PubMed] [Google Scholar]
  11. Strong R. W., Lynch S. V., Ong T. H., Matsunami H., Koido Y., Balderson G. A. Successful liver transplantation from a living donor to her son. N Engl J Med. 1990 May 24;322(21):1505–1507. doi: 10.1056/NEJM199005243222106. [DOI] [PubMed] [Google Scholar]
  12. Taki Y., Gubernatis G., Yamaoka Y., Oellerich M., Yamamoto Y., Ringe B., Okamoto R., Bunzendahl H., Beneking M., Burdelski M. Significance of arterial ketone body ratio measurement in human liver transplantation. Transplantation. 1990 Mar;49(3):535–539. doi: 10.1097/00007890-199003000-00012. [DOI] [PubMed] [Google Scholar]
  13. Todo S., Fung J. J., Starzl T. E., Tzakis A., Demetris A. J., Kormos R., Jain A., Alessiani M., Takaya S., Shapiro R. Liver, kidney, and thoracic organ transplantation under FK 506. Ann Surg. 1990 Sep;212(3):295–307. doi: 10.1097/00000658-199009000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Uno S., Ito S., Kurono M., Yamaoka Y., Kamiyama Y., Ozawa K. A simple and sensitive assay for blood ketone bodies using highly purified 3-hydroxybutyrate dehydrogenase. Clin Chim Acta. 1987 Sep 30;168(2):253–255. doi: 10.1016/0009-8981(87)90295-6. [DOI] [PubMed] [Google Scholar]
  15. Yamaoka Y., Ozawa K., Tanaka A., Mori K., Morimoto T., Shimahara Y., Zaima M., Tanaka K., Kumada K. New devices for harvesting a hepatic graft from a living donor. Transplantation. 1991 Jul;52(1):157–160. doi: 10.1097/00007890-199107000-00035. [DOI] [PubMed] [Google Scholar]
  16. Zmijewski C. M. Human leukocyte antigen matching in renal transplantation: review and current status. J Surg Res. 1985 Jan;38(1):66–87. doi: 10.1016/0022-4804(85)90011-3. [DOI] [PubMed] [Google Scholar]

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