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. 1994 Mar;219(3):275–280. doi: 10.1097/00000658-199403000-00007

Surgical treatment of 724 carcinomas of the gallbladder. Results of the French Surgical Association Survey.

P Cubertafond 1, A Gainant 1, G Cucchiaro 1
PMCID: PMC1243135  PMID: 8147608

Abstract

OBJECTIVE: The objective of this study was to evaluate the benefit of an aggressive approach to gallbladder carcinoma on long-term survival. SUMMARY BACKGROUND DATA: Recent studies have shown that an aggressive surgical treatment of bile duct carcinoma can be associated with a surprising long-term survival. However, recent data on gallbladder carcinoma are not available. METHODS: Data were obtained from a questionnaire sent to 73 institutions in France, Europe, and overseas, and they were analyzed retrospectively. The review included an analysis of patient sex and age, associated hepatobiliary diseases, symptoms and signs, diagnostic tests, operative management, pathology reports, and survival. RESULTS: Seventy-eight per cent of the patients were women, and 22% were men (p < 0.001). Gallstones were present in 86% of the cases. Four per cent of the patients had Tis stage lesions, 11% had T1 to T2 stage lesions, and 85% had T3 to T4 stage lesions (p < 0.001). Pain was the most frequent symptom (77%). Twenty-three per cent of the patients underwent curative operations, and 77% had a palliative treatment (25% of the patients underwent exploratory laparotomy). Exploratory laparotomy was followed by the highest mortality rate (66%), and older patients (> 70 years) had a higher operative risk (p < 0.04). The overall median survival was 3 months, and long-term survival correlated with the cancer stage (Tis, > 60 months; T1 to T2, > 22 months, and T3 to T4, 2 to 8 months). No differences were observed among the different surgical procedures adopted. CONCLUSIONS: No progress has been made in the last 10 years in the treatment of gallbladder malignancies.

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Selected References

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  1. APPLEMAN R. M., MORLOCK C. G., DAHLIN D. C., ADSON M. A. LONG TERM SURVIVAL IN CARCINOMA OF THE GALLBLADDER. Surg Gynecol Obstet. 1963 Oct;117:459–464. [PubMed] [Google Scholar]
  2. APPLEMAN R. M., MORLOCK C. G., DAHLIN D. C., ADSON M. A. LONG TERM SURVIVAL IN CARCINOMA OF THE GALLBLADDER. Surg Gynecol Obstet. 1963 Oct;117:459–464. [PubMed] [Google Scholar]
  3. Albores-Saavedra J., de Jesus Manrique J., Angeles-Angeles A., Henson D. E. Carcinoma in situ of the gallbladder. A clinicopathologic study of 18 cases. Am J Surg Pathol. 1984 May;8(5):323–333. doi: 10.1097/00000478-198405000-00001. [DOI] [PubMed] [Google Scholar]
  4. Bergdahl L. Gallbladder carcinoma first diagnosed at microscopic examination of gallbladders removed for presumed benign disease. Ann Surg. 1980 Jan;191(1):19–22. doi: 10.1097/00000658-198001000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Bhargava D. K., Sarin S., Verma K., Kapur B. M. Laparoscopy in carcinoma of the gallbladder. Gastrointest Endosc. 1983 Feb;29(1):21–22. doi: 10.1016/s0016-5107(83)72492-2. [DOI] [PubMed] [Google Scholar]
  6. Burgess P., Murphy P. D., Clague M. B. Adenocarcinoma of the gallbladder--a 5 year review of outcome in Newcastle upon Tyne. J R Soc Med. 1991 Feb;84(2):84–86. doi: 10.1177/014107689108400210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. De Dios Vega J. F., Hita Pérez J., Muro Gonzalez J., Cosme Jimenez A., Miño Fugarolas G., Cano López J. M. Valor de la laparoscopia en el diagnóstico del cáncer de vesícula biliar. Estudio de 34 casos. Rev Esp Enferm Apar Dig. 1973 Dec 15;41(8):867–874. [PubMed] [Google Scholar]
  8. Donohue J. H., Nagorney D. M., Grant C. S., Tsushima K., Ilstrup D. M., Adson M. A. Carcinoma of the gallbladder. Does radical resection improve outcome? Arch Surg. 1990 Feb;125(2):237–241. doi: 10.1001/archsurg.1990.01410140115019. [DOI] [PubMed] [Google Scholar]
  9. Evander A., Ihse I. Evaluation of intended radical surgery in carcinoma of the gallbladder. Br J Surg. 1981 Mar;68(3):158–160. doi: 10.1002/bjs.1800680306. [DOI] [PubMed] [Google Scholar]
  10. FAHIM R. B., McDONALD J. R., RICHARDS J. C., FERRIS D. O. Carcinoma of the gallbladder: a study of its modes of spread. Ann Surg. 1962 Jul;156:114–124. doi: 10.1097/00000658-196207000-00021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GLENN F., HAYS D. M. The scope of radical surgery in the treatment of malignant tumors of the extrahepatic biliary tract. Surg Gynecol Obstet. 1954 Nov;99(5):529–541. [PubMed] [Google Scholar]
  12. Gardner M. J., Altman D. G. Confidence intervals rather than P values: estimation rather than hypothesis testing. Br Med J (Clin Res Ed) 1986 Mar 15;292(6522):746–750. doi: 10.1136/bmj.292.6522.746. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Greve J. W., Maessen J. G., Tiebosch T., Buurman W. A., Gouma D. J. Prevention of postoperative complications in jaundiced rats. Internal biliary drainage versus oral lactulose. Ann Surg. 1990 Aug;212(2):221–227. doi: 10.1097/00000658-199008000-00018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Itai Y., Araki T., Yoshikawa K., Furui S., Yashiro N., Tasaka A. Computed tomography of gallbladder carcinoma. Radiology. 1980 Dec;137(3):713–718. doi: 10.1148/radiology.137.3.7444054. [DOI] [PubMed] [Google Scholar]
  15. Jönsson P. E., Pettersson B. A. Carcinoma of the gallbladder--a natural history type of study. J Surg Oncol. 1982 Dec;21(4):215–218. doi: 10.1002/jso.2930210404. [DOI] [PubMed] [Google Scholar]
  16. Koga A., Watanabe K., Fukuyama T., Takiguchi S., Nakayama F. Diagnosis and operative indications for polypoid lesions of the gallbladder. Arch Surg. 1988 Jan;123(1):26–29. doi: 10.1001/archsurg.1988.01400250028003. [DOI] [PubMed] [Google Scholar]
  17. Morrow C. E., Sutherland D. E., Florack G., Eisenberg M. M., Grage T. B. Primary gallbladder carcinoma: significance of subserosal lesions and results of aggressive surgical treatment and adjuvant chemotherapy. Surgery. 1983 Oct;94(4):709–714. [PubMed] [Google Scholar]
  18. Nakamura S., Sakaguchi S., Suzuki S., Muro H. Aggressive surgery for carcinoma of the gallbladder. Surgery. 1989 Sep;106(3):467–473. [PubMed] [Google Scholar]
  19. Nakamura S., Sakaguchi S., Suzuki S., Muro H. Aggressive surgery for carcinoma of the gallbladder. Surgery. 1989 Sep;106(3):467–473. [PubMed] [Google Scholar]
  20. Ouchi K., Owada Y., Matsuno S., Sato T. Prognostic factors in the surgical treatment of gallbladder carcinoma. Surgery. 1987 Jun;101(6):731–737. [PubMed] [Google Scholar]
  21. Perpetuo M. D., Valdivieso M., Heilbrun L. K., Nelson R. S., Connor T., Bodey G. P. Natural history study of gallbladder cancer: a review of 36 years experience at M. D. Anderson Hospital and Tumor Institute. Cancer. 1978 Jul;42(1):330–335. doi: 10.1002/1097-0142(197807)42:1<330::aid-cncr2820420150>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  22. Reding R., Buard J. L., Lebeau G., Launois B. Surgical management of 552 carcinomas of the extrahepatic bile ducts (gallbladder and periampullary tumors excluded). Results of the French Surgical Association Survey. Ann Surg. 1991 Mar;213(3):236–241. doi: 10.1097/00000658-199103000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Roberts J. W., Daugherty S. F. Primary carcinoma of the gallbladder. Surg Clin North Am. 1986 Aug;66(4):743–749. doi: 10.1016/s0039-6109(16)43985-x. [DOI] [PubMed] [Google Scholar]
  24. Tanga M. R., Ewing J. B. Primary malignant tumors of the gallbladder: report of 43 cases. Surgery. 1970 Mar;67(3):418–426. [PubMed] [Google Scholar]
  25. Tashiro S., Konno T., Mochinaga M., Nakakuma K., Murata E., Yokoyama I. Treatment of carcinoma of the gallbladder in Japan. Jpn J Surg. 1982;12(2):98–104. doi: 10.1007/BF02469375. [DOI] [PubMed] [Google Scholar]
  26. Tompkins R. K., Thomas D., Wile A., Longmire W. P., Jr Prognostic factors in bile duct carcinoma: analysis of 96 cases. Ann Surg. 1981 Oct;194(4):447–457. doi: 10.1097/00000658-198110000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Trede M., Schwall G. The complications of pancreatectomy. Ann Surg. 1988 Jan;207(1):39–47. doi: 10.1097/00000658-198801000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Tsunoda T., Tsuchiya R., Harada N., Izawa K., Yamaguchi T., Yamamoto K., Motoshima K., Tomioka T., Matsuo S., Eto T. The surgical treatment for carcinoma of the gallbladder--rationale of the second-look operation for inapparent carcinoma. Jpn J Surg. 1987 Nov;17(6):478–486. doi: 10.1007/BF02470752. [DOI] [PubMed] [Google Scholar]

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