Content of this journal is licensed under a Dear Editor,
We appreciate the insightful comments regarding our published manuscript on pediatric urinary stone disease.1 It is encouraging to see that our findings resonate with observations from other regions, highlighting the strong genetic component in the etiology of pediatric urinary stone disease. The similarities in hereditary predisposition emphasize the importance of genetic screening and family history assessment in managing affected children.
The discussion on metabolic abnormalities further underscores the regional variations in stone composition and risk factors. The prevalence of hyperuricosuria and hypercalciuria in warmer climates aligns with findings in our study, reinforcing the role of environmental influences on stone formation and the need for targeted preventive strategies tailored to specific geographical regions.
The incidence of bladder stones has decreased in developed countries due to improved socioeconomic conditions and nutrition, but they remain prevalent in developing regions. In our study, bladder stones were not detected in our patients; thus, we have no data regarding the incidence of these stones in our cohort. This issue remains relevant, particularly in developing countries. In this letter, the authors emphasized that hydroureteronephrosis may also occur in some cases other than ureteropelvic junction stenosis or vesicourethral reflux. Indeed, Rianthavorn et al2 reported isolated hydronephrosis (HN) in children as HN detected without another cause such as ureteropelvic junction (UPJ) stenosis or vesicoureteral reflux (VUR). The frequency rates we stated as HN in our article consist of isolated HN cases for which we cannot show the cause other than UPJ stenosis, VUR, or urolithiasis, etc. Therefore, the reported frequency of HN mainly includes isolated HN cases.
In conclusion, we thank the author for their thoughtful comments and clinical insights.
Sincerely,
For all authors,
Utku Dönger
Funding Statement
This study received no funding.
Footnotes
Peer-review: Externally peer-reviewed.
Author Contributions: Concept – U.D.; Design – U.D.; Supervision – U.D.; Resources – E.B.; Materials – U.D.; Data Collection and/or Processing – U.D.; Analysis and/or Interpretation – U.D.; Literature Search – U.D.; Writing – U.D.; Critical Review – U.D.
Declaration of Interests: The author has no conflict of interests to declare.
References
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