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. 2025 Sep 15;15:32520. doi: 10.1038/s41598-025-14607-7

Retraction Note: Rechallenge therapy versus tyrosine kinase inhibitor (TKI) for advanced metastatic colorectal cancer: a retrospective study

Chenming Liu 1,#, Jintao Chen 3,#, Yuxing Liu 2,
PMCID: PMC12436611  PMID: 40954147

Retraction of: Scientific Reports 10.1038/s41598-025-86575-x, published online 04 February 2025

Authors have retracted this Article.

After publication of this Article, the Authors identified an error in Table 1 describing baseline characteristics of the patients. In that table, as a result of a clerical error during preparation of the manuscript, the clinical data of the TKI group was incorrectly labelled as the Rechallenge group, and vice versa. This error impacts Cox regression analyses the results of which are presented in Tables 2 and 3. The originally reported hazard ration and statistical significance in both univariate and multivariate models is incorrect. As such, the conclusion that chemotherapy challenge is an independent protective factor for OS and PFS no longer holds. This in turn invalidates the main conclusion of this study suggesting that rechallenge therapy is superior to the TKI in the matched cohort.

All Authors agree with the retraction and its wording.


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