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. 1981;319:419–429. doi: 10.1113/jphysiol.1981.sp013918

Control of canine renin release: macula densa requires prostaglandin synthesis.

J G Gerber, A S Nies, R D Olsen
PMCID: PMC1243848  PMID: 6798201

Abstract

1. The macula densa mechanism of renin release was functionally isolated in uninephrectomized, anaesthetized dogs by producing renal denervation, beta-adrenoceptor blockade, and maximum renal vasodilation with an infusion of papaverine into the renal artery. 2. A suprarenal aortic clamp was adjusted to reduce renal perfusion pressure by 50% which resulted in a 90% reduction in urinary sodium excretion and a two to threefold increase in plasma renin activity within 10 min. 3. Indomethacin (8 mg/kg) or meclofenamic acid (10 mg/kg) inhibited the rise plasma renin activity produced by the decrease in renal perfusion pressure in this model, although a comparable decrease in urinary sodium excretion was achieved. 4. We conclude that the macula densa mechanism of renin release is blocked by inhibition of prostaglandin synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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