表 1. Different types of FMD regimens applied in animal models.

动物模型所应用的FMD方案

Study	Cycles of FMD	Duration of FMD	Follow-up	Comparison	The fist day	The remaining days
BRANDHORST, et al. 2015[22]	2/month	4 d	24 months	The diet on day 1 consists of a mix of various low-calorie broth powders, a vegetable medley powder, extra virgin olive oil, and essential fatty acids; the diet on day 2-4 consists of low-calorie broth powders and glycerol.	Day 1 diet contains 7.67 kJ/g (provided at about 50% of normal daily intake; 0.46 kJ/g protein, 2.2 kJ/g carbohydrate, 5.00 kJ/g fat).	The day 2-4 diet is identical on all feeding days and contains 1.48 kJ/g (provided at about 10% of normal daily intake; 0.01 kJ/g protein/fat and 1.47 kJ/g carbohydrates).
Di BIASE, et al. 2016[25]	2/month	4 d	42 d	Contains 3.75 kcal/g of digestible energy with calories supplied by protein, carbohydrate, and fat in a percent ratio of 25:58:17.	The day 1 diet contains 1.88 kcal/g.	The day 2-4 diet is identical on all feeding days and contains 0.36 kcal/g.
CHOI, et al. 2016[26]	1/week	3 d	30 d	Contains 15.69 kJ/g digestible energy (animal-based protein at 3.92 kJ/g, carbohydrate at 9.1 kJ/g, and fat at 2.67 kJ/g)	Mice consume about 50% of their normal caloric intake (7.87 kJ/g).	Mice consume about 10% of their normal caloric intake (1.51 kJ/g).
CHENG, et al. 2017[27]	3/month	4 d	3 months	Comprises proprietary formulations of vegetable-based soups, energy bars, energy drinks, chip snacks, tea, and a supplement providing high levels of minerals, vitamins, and essential fatty acids	50% of the standard daily calorie intake	10% of normal daily calorie intake
RANGAN, et al. 2019[28]	2 cycles	4 d	8 weeks	A combination of flavored broth mixes, extra virgin olive oil, essential fatty acids, vegetable powders, vitamins, and minerals were thoroughly mixed and bound together with heated hydrogel on day 1. On days 2-4, a combination of flavored broth mixes, glycerol, and hydrogel was fed to mice.	About 50% of their normal caloric intake (8.08 kJ/g; 0.56 kJ fat, 0.68 kJ carbohydrates, and 0.11 kJ protein).	About 10% of their normal caloric intake (1.10 kJ/g; 0.27 kJ carbohydrates).